| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44045368 | HTLV-1 | ENSG00000112033.14 | protein_coding | PPARD | No | No | 5467 | Q03181 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PPARD |
|---|---|
| DrugBank ID | DB00605 |
| Drug Name | Sulindac |
| Target ID | BE0001007 |
| UniProt ID | Q03181 |
| Regulation Type | negative modulator |
| PubMed IDs | 10555149; 14506281; 16091736; 16418176; 17409426 |
| Citations | He TC, Chan TA, Vogelstein B, Kinzler KW: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29;99(3):335-45.@@Babbar N, Ignatenko NA, Casero RA Jr, Gerner EW: Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75. Epub 2003 Sep 23.@@Jarvis MC, Gray TJ, Palmer CN: Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line. Oncogene. 2005 Dec 8;24(55):8211-5.@@Kim DJ, Prabhu KS, Gonzalez FJ, Peters JM: Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Carcinogenesis. 2006 May;27(5):1105-12. Epub 2006 Jan 16.@@Liou JY, Ghelani D, Yeh S, Wu KK: Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. Cancer Res. 2007 Apr 1;67(7):3185-91. |
| Groups | Approved; Investigational |
| Direct Classification | Indenes and isoindenes |
| SMILES | CC1=C(CC(O)=O)C2=CC(F)=CC=C2C1=C/C1=CC=C(C=C1)S(C)=O |
| Pathways | Sulindac Action Pathway |
| PharmGKB | PA451565 |
| ChEMBL | CHEMBL15770 |
