| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20032009 | HPV | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44018687 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44018688 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44003389 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44018689 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44009683 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44012424 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44013628 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44033913 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
| TVIS44033910 | HTLV-1 | ENSG00000184588.18 | protein_coding | PDE4B | No | No | 5142 | Q07343 X5DNX5 X5DR82 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDE4B |
|---|---|
| DrugBank ID | DB01412 |
| Drug Name | Theobromine |
| Target ID | BE0000487 |
| UniProt ID | Q07343 |
| Regulation Type | inhibitor |
| PubMed IDs | 11692087; 15095008; 17514358; 18568240 |
| Citations | Essayan DM: Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol. 2001 Nov;108(5):671-80.@@Fisone G, Borgkvist A, Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.@@Daly JW: Caffeine analogs: biomedical impact. Cell Mol Life Sci. 2007 Aug;64(16):2153-69.@@Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R: Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo). 2008 Jun;63(3):321-8. |
| Groups | Investigational |
| Direct Classification | Xanthines |
| SMILES | CN1C=NC2=C1C(=O)NC(=O)N2C |
| Pathways | Caffeine Metabolism |
| PharmGKB | PA451646 |
| ChEMBL | CHEMBL1114 |
