| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10009794 | HBV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS10036366 | HBV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058841 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058842 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058843 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058844 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058845 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058846 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058847 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
| TVIS30058848 | HIV | ENSG00000114200.10 | protein_coding | BCHE | No | No | 590 | P06276 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCHE |
|---|---|
| DrugBank ID | DB00843 |
| Drug Name | Donepezil |
| Target ID | BE0002180 |
| UniProt ID | P06276 |
| Regulation Type | inducer |
| PubMed IDs | 16863459; 14751402; 23930233; 11256231 |
| Citations | Seltzer B: Donepezil: a review. Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):527-36. doi: 10.1517/17425255.1.3.527 .@@Liston DR, Nielsen JA, Villalobos A, Chapin D, Jones SB, Hubbard ST, Shalaby IA, Ramirez A, Nason D, White WF: Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. Eur J Pharmacol. 2004 Feb 13;486(1):9-17. doi: 10.1016/j.ejphar.2003.11.080.@@Nordberg A, Ballard C, Bullock R, Darreh-Shori T, Somogyi M: A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease. Prim Care Companion CNS Disord. 2013;15(2). pii: 12r01412. doi: 10.4088/PCC.12r01412. Epub 2013 Mar 7.@@Ogura H, Kosasa T, Kuriya Y, Yamanishi Y: Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13. |
| Groups | Approved |
| Direct Classification | N-benzylpiperidines |
| SMILES | COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1 |
| Pathways | |
| PharmGKB | PA449394 |
| ChEMBL | CHEMBL502 |
