| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30058051 | HIV | ENSG00000151577.14 | protein_coding | DRD3 | No | No | 1814 | A1A4V4 E9PCM4 P35462 X5D2G4 |
| TVIS20057150 | HPV | ENSG00000151577.14 | protein_coding | DRD3 | No | No | 1814 | A1A4V4 E9PCM4 P35462 X5D2G4 |
| TVIS20057354 | HPV | ENSG00000151577.14 | protein_coding | DRD3 | No | No | 1814 | A1A4V4 E9PCM4 P35462 X5D2G4 |
| TVIS20040604 | HPV | ENSG00000151577.14 | protein_coding | DRD3 | No | No | 1814 | A1A4V4 E9PCM4 P35462 X5D2G4 |
| TVIS44006680 | HTLV-1 | ENSG00000151577.14 | protein_coding | DRD3 | No | No | 1814 | A1A4V4 E9PCM4 P35462 X5D2G4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DRD3 |
|---|---|
| DrugBank ID | DB00502 |
| Drug Name | Haloperidol |
| Target ID | BE0000581 |
| UniProt ID | P35462 |
| Regulation Type | inverse agonist |
| PubMed IDs | 7520908; 19496999; 18831971; 16123775; 9536001 |
| Citations | Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12.@@Tuppurainen H, Kuikka JT, Viinamaki H, Husso M, Tiihonen J: Dopamine D2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine. Psychiatry Clin Neurosci. 2009 Aug;63(4):529-37. doi: 10.1111/j.1440-1819.2009.01982.x. Epub 2009 May 22.@@Tadori Y, Forbes RA, McQuade RD, Kikuchi T: Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors. Eur J Pharmacol. 2008 Nov 12;597(1-3):27-33. doi: 10.1016/j.ejphar.2008.09.008. Epub 2008 Sep 20.@@Kessler RM, Ansari MS, Riccardi P, Li R, Jayathilake K, Dawant B, Meltzer HY: Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol. Neuropsychopharmacology. 2005 Dec;30(12):2283-9.@@Malmberg, Mikaels, Mohell N: Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding. J Pharmacol Exp Ther. 1998 Apr;285(1):119-26. |
| Groups | Approved |
| Direct Classification | Alkyl-phenylketones |
| SMILES | OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA449841 |
| ChEMBL | CHEMBL54 |
