| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10038074 | HBV | ENSG00000165646.14 | protein_coding | SLC18A2 | No | No | 6571 | Q05940 |
| TVIS10046857 | HBV | ENSG00000165646.14 | protein_coding | SLC18A2 | No | No | 6571 | Q05940 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC18A2 |
|---|---|
| DrugBank ID | DB01577 |
| Drug Name | Metamfetamine |
| Target ID | BE0000118 |
| UniProt ID | Q05940 |
| Regulation Type | inhibitor |
| PubMed IDs | 21177475; 15955613; 7751968; 19429089; 17209801 |
| Citations | Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP: meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. J Pharmacol Exp Ther. 2011 Mar;336(3):940-51. doi: 10.1124/jpet.110.175117. Epub 2010 Dec 21.@@Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33.@@Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A: Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci. 1995 May;15(5 Pt 2):4102-8.@@Yasumoto S, Tamura K, Karasawa J, Hasegawa R, Ikeda K, Yamamoto T, Yamamoto H: Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2. Neurosci Lett. 2009 May 1;454(3):229-32. doi: 10.1016/j.neulet.2009.03.049. Epub 2009 Mar 18.@@Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. |
| Groups | Approved; Illicit; Withdrawn |
| Direct Classification | Amphetamines and derivatives |
| SMILES | CN[C@@H](C)CC1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA450403 |
| ChEMBL | CHEMBL1201201 |
