| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10038074 | HBV | ENSG00000165646.14 | protein_coding | SLC18A2 | No | No | 6571 | Q05940 |
| TVIS10046857 | HBV | ENSG00000165646.14 | protein_coding | SLC18A2 | No | No | 6571 | Q05940 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC18A2 |
|---|---|
| DrugBank ID | DB04844 |
| Drug Name | Tetrabenazine |
| Target ID | BE0000118 |
| UniProt ID | Q05940 |
| Regulation Type | inhibitor |
| PubMed IDs | 17233532; 11752352; 19571144; 19223416; 20007701; 20135628 |
| Citations | Zheng G, Dwoskin LP, Crooks PA: Vesicular monoamine transporter 2: role as a novel target for drug development. AAPS J. 2006 Nov 10;8(4):E682-92.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Kim YS, Shin JH, Hall FS, Linden DJ: Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. J Neurosci. 2009 Jul 1;29(26):8530-8. doi: 10.1523/JNEUROSCI.0468-09.2009.@@Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE: 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med. 2009 Mar;50(3):382-9. doi: 10.2967/jnumed.108.054866. Epub 2009 Feb 17.@@Gros Y, Schuldiner S: Directed evolution reveals hidden properties of VMAT, a neurotransmitter transporter. J Biol Chem. 2010 Feb 12;285(7):5076-84. doi: 10.1074/jbc.M109.081216. Epub 2009 Dec 10.@@Wimalasena K: Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry. Med Res Rev. 2011 Jul;31(4):483-519. doi: 10.1002/med.20187. Epub 2010 Feb 4. |
| Groups | Approved; Investigational |
| Direct Classification | Tetrahydroisoquinolines |
| SMILES | COC1=C(OC)C=C2C3CC(=O)C(CC(C)C)CN3CCC2=C1 |
| Pathways | |
| PharmGKB | PA140222719 |
| ChEMBL | CHEMBL117785 |
