| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10044552 | HBV | ENSG00000169083.18 | protein_coding | AR | Yes | No | 367 | A0A087WUX9 P10275 |
| TVIS10052789 | HBV | ENSG00000169083.18 | protein_coding | AR | Yes | No | 367 | A0A087WUX9 P10275 |
| TVIS30073184 | HIV | ENSG00000169083.18 | protein_coding | AR | Yes | No | 367 | A0A087WUX9 P10275 |
| TVIS44024288 | HTLV-1 | ENSG00000169083.18 | protein_coding | AR | Yes | No | 367 | A0A087WUX9 P10275 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AR |
|---|---|
| DrugBank ID | DB00421 |
| Drug Name | Spironolactone |
| Target ID | BE0000132 |
| UniProt ID | P10275 |
| Regulation Type | antagonist |
| PubMed IDs | 18819053; 15947888; 28024992; 32119308 |
| Citations | Ye P, Yamashita T, Pollock DM, Sasano H, Rainey WE: Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm Metab Res. 2009 Jan;41(1):35-9. doi: 10.1055/s-0028-1087188. Epub 2008 Sep 25.@@Sica DA: Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Fail Rev. 2005 Jan;10(1):23-9. doi: 10.1007/s10741-005-2345-1.@@Carone L, Oxberry SG, Twycross R, Charlesworth S, Mihalyo M, Wilcock A: Spironolactone. J Pain Symptom Manage. 2017 Feb;53(2):288-292. doi: 10.1016/j.jpainsymman.2016.12.320. Epub 2016 Dec 23.@@Patibandla S, Heaton J, Kyaw H: Spironolactone. . |
| Groups | Approved |
| Direct Classification | Spironolactones and derivatives |
| SMILES | [H][C@@]12CC[C@@]3(CCC(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@]([H])(CC2=CC(=O)CC[C@]12C)SC(C)=O |
| Pathways | Spironolactone Action Pathway |
| PharmGKB | PA451483 |
| ChEMBL | CHEMBL1393 |
