| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10037354 | HBV | ENSG00000080644.16 | protein_coding | CHRNA3 | No | No | 1136 | P32297 |
| TVIS10032120 | HBV | ENSG00000080644.16 | protein_coding | CHRNA3 | No | No | 1136 | P32297 |
| TVIS10039140 | HBV | ENSG00000080644.16 | protein_coding | CHRNA3 | No | No | 1136 | P32297 |
| TVIS30039129 | HIV | ENSG00000080644.16 | protein_coding | CHRNA3 | No | No | 1136 | P32297 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRNA3 |
|---|---|
| DrugBank ID | DB00848 |
| Drug Name | Levamisole |
| Target ID | BE0003585 |
| UniProt ID | P32297 |
| Regulation Type | agonist |
| PubMed IDs | 17139284; 17016423; 15280391; 17314321; 17629760; 19668355; 10592235 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Culetto E, Baylis HA, Richmond JE, Jones AK, Fleming JT, Squire MD, Lewis JA, Sattelle DB: The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. J Biol Chem. 2004 Oct 8;279(41):42476-83. Epub 2004 Jul 27.@@Rayes D, Flamini M, Hernando G, Bouzat C: Activation of single nicotinic receptor channels from Caenorhabditis elegans muscle. Mol Pharmacol. 2007 May;71(5):1407-15. Epub 2007 Feb 21.@@Parker S, Peterkin HS, Baylis HA: Muscular dystrophy associated mutations in caveolin-1 induce neurotransmission and locomotion defects in Caenorhabditis elegans. Invert Neurosci. 2007 Sep;7(3):157-64. Epub 2007 Jul 13.@@Hu Y, Xiao SH, Aroian RV: The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. doi: 10.1371/journal.pntd.0000499.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
| Groups | Approved; Investigational; Vet_approved; Withdrawn |
| Direct Classification | Imidazothiazoles |
| SMILES | C1CN2C[C@@H](N=C2S1)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA450205 |
| ChEMBL | CHEMBL1454 |
