Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for EIF4B

Basic gene info.	Gene symbol	EIF4B
	Gene name	eukaryotic translation initiation factor 4B
	Synonyms	EIF-4B\|PRO1843
	Cytomap	UCSC genome browser: 12q13.13
	Genomic location	chr12 :53400061-53435993
	Type of gene	protein-coding
	RefGenes	NM_018507.1, NM_001300821.1,NM_001417.5,
	Ensembl id	ENSG00000063046
	Description	-
	Modification date	20141207
dbXrefs	MIM : 603928
	HGNC : HGNC
	Ensembl : ENSG00000063046
	HPRD : 04892
	Vega : OTTHUMG00000169570
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_EIF4B
	BioGPS: 1975
	Gene Expression Atlas: ENSG00000063046
	The Human Protein Atlas: ENSG00000063046
Pathway	NCI Pathway Interaction Database: EIF4B
	KEGG: EIF4B
	REACTOME: EIF4B
	ConsensusPathDB
	Pathway Commons: EIF4B
Metabolism	MetaCyc: EIF4B
	HUMANCyc: EIF4B
Regulation	Ensembl's Regulation: ENSG00000063046
	miRBase: chr12 :53,400,061-53,435,993
	TargetScan: NM_018507
	cisRED: ENSG00000063046
Context	iHOP: EIF4B
	cancer metabolism search in PubMed: EIF4B
	UCL Cancer Institute: EIF4B
Assigned class in ccmGDB	C

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Phenotypic Information for EIF4B(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: EIF4B
	Familial Cancer Database: EIF4B

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA

Others
OMIM
Orphanet
Disease	KEGG Disease: EIF4B
	MedGen: EIF4B (Human Medical Genetics with Condition)
	ClinVar: EIF4B
Phenotype	MGI: EIF4B (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: EIF4B

Mutations for EIF4B

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
pancreas	EIF4B	chr12	53430407	53430427	KRT8	chr12	53335846	53335866

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows EIF4B related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG213873	EIF4B	34	379	12	53408383	53408728	TNNC1	379	447	3	52486122	52486190
AW386153	ZNF384	21	348	12	6775904	6776442	EIF4B	337	405	12	53433141	53433209
BF882453	FYTTD1	1	134	3	197481753	197481885	EIF4B	129	226	12	53435318	53435414

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=41)	Stat. for Synonymous SNVs (# total SNVs=4)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr12:53421963-53421963	p.D324N	3
chr12:53413733-53413733	p.E134Q	2
chr12:53421634-53421634	p.R246C	2
chr12:53421965-53421965	p.D324E	2
chr12:53421577-53421577	p.R227C	2
chr12:53410309-53410309	p.A22A	2
chr12:53413723-53413723	p.P130P	1
chr12:53427811-53427811	p.R401W	1
chr12:53421578-53421578	p.R227H	1
chr12:53431337-53431337	p.W484L	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	1	1	2	1		2			2	1	6	5				5	4		6
# mutation	1	1	1	2	1		2			2	1	6	5				5	4		7
nonsynonymous SNV		1	1	2	1		2			2		6	5				4	4		7
synonymous SNV	1										1						1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr12:53413733	p.E134Q	2
chr12:53421577	p.R227C	2
chr12:53421946	p.D50H	1
chr12:53410335	p.R287R	1
chr12:53431273	p.E481Q	1
chr12:53416289	p.D60N	1
chr12:53427604	p.D289N	1
chr12:53410353	p.Q496E	1
chr12:53431279	p.A65V	1
chr12:53416313	p.Y298C	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for EIF4B in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for EIF4B

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ATF7,BTF3,CCNG1,CCNI,EEF1A1,EEF2,EIF4B, FAM172A,HNRNPA1L2,IGBP1,IMPDH2,KIAA0141,LETMD1,MBLAC2, MRPS27,NACA,NSA2,PCBP2,RNF41,SP1,ZNF740	ABCB7,CCNI,CSNK2A1,DYM,EIF2A,EIF3E,EIF4A2, EIF4B,ST13P4,GPD1L,GTF3C3,LIAS,LRPPRC,METAP2, MRPL45,MRPS27,MTIF2,PMPCB,RSL1D1,TATDN1,UBE4B

CS,EEF1G,EEF2,EIF3L,EIF4B,HNRNPA1,HNRNPA1L2, LETMD1,LOC144438,LTA4H,METAP2,NACA,NACAP1,NAP1L1, PCBP2,RPL3,RPL41,RPL4,RPL6,TMEM5,ZNF740	ADRB1,CCNI,CREBL2,CTPS2,EEF2,EIF2S3,EIF3H, EIF3L,EIF4B,FXR1,GLTSCR2,LTA4H,NACA,PCBP2, RPL22,SLC41A3,ST13,WDR48,ZNF395,ZNF766,ZNF830

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for EIF4B

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00877	eukaryotic translation initiation factor 4B	approved; investigational	Sirolimus

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Cross referenced IDs for EIF4B

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information