Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for PLA2G2E

Basic gene info.	Gene symbol	PLA2G2E
	Gene name	phospholipase A2, group IIE
	Synonyms	GIIE sPLA2\|sPLA2-IIE
	Cytomap	UCSC genome browser: 1p36.13
	Genomic location	chr1 :20246799-20250110
	Type of gene	protein-coding
	RefGenes	NM_014589.2,
	Ensembl id	ENSG00000188784
	Description	group IIE secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2E
	Modification date	20141207
dbXrefs	HGNC : HGNC
	HPRD : 07143
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PLA2G2E
	BioGPS: 30814
	Gene Expression Atlas: ENSG00000188784
	The Human Protein Atlas: ENSG00000188784
Pathway	NCI Pathway Interaction Database: PLA2G2E
	KEGG: PLA2G2E
	REACTOME: PLA2G2E
	ConsensusPathDB
	Pathway Commons: PLA2G2E
Metabolism	MetaCyc: PLA2G2E
	HUMANCyc: PLA2G2E
Regulation	Ensembl's Regulation: ENSG00000188784
	miRBase: chr1 :20,246,799-20,250,110
	TargetScan: NM_014589
	cisRED: ENSG00000188784
Context	iHOP: PLA2G2E
	cancer metabolism search in PubMed: PLA2G2E
	UCL Cancer Institute: PLA2G2E
Assigned class in ccmGDB	C

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Phenotypic Information for PLA2G2E(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: PLA2G2E
	Familial Cancer Database: PLA2G2E

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM KEGG_ARACHIDONIC_ACID_METABOLISM KEGG_LINOLEIC_ACID_METABOLISM KEGG_ALPHA_LINOLENIC_ACID_METABOLISM REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: PLA2G2E
	MedGen: PLA2G2E (Human Medical Genetics with Condition)
	ClinVar: PLA2G2E
Phenotype	MGI: PLA2G2E (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: PLA2G2E

Mutations for PLA2G2E

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PLA2G2E related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=14)	Stat. for Synonymous SNVs (# total SNVs=4)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:20249129-20249129	p.P54S	3
chr1:20246820-20246820	p.G137W	2
chr1:20248789-20248789	p.?	2
chr1:20248809-20248809	p.E90Q	2
chr1:20248856-20248856	p.K74R	1
chr1:20249202-20249202	p.E29D	1
chr1:20248863-20248863	p.L72M	1
chr1:20249204-20249204	p.E29*	1
chr1:20248866-20248866	p.R71S	1
chr1:20249208-20249208	p.M27I	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	3	1		4			1					2	1				4	4		4
# mutation	3	1		4			1					2	1				4	4		4
nonsynonymous SNV	3	1		2								1	1				4	4		4
synonymous SNV				2			1					1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:20246820	p.G137R	2
chr1:20249129	p.P54T	2
chr1:20248809	p.S51C	1
chr1:20249233	p.K34E	1
chr1:20248863	p.X143X	1
chr1:20249235	p.E29D	1
chr1:20248866	p.P140T	1
chr1:20250034	p.M27I	1
chr1:20246801	p.G25A	1
chr1:20248869	p.P131S	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for PLA2G2E in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PLA2G2E

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA	NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA

C2orf82,CADM2,CDH22,DMRT3,FAM47B,GLYATL3,GPR17, GPX5,MAOB,NOTUM,NTS,OR2M5,OR4C16,OR5I1, OR5L1,OR8B12,PLA2G2E,RASGRF1,TBX4,TKTL1,ZNF679	NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PLA2G2E

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00233	phospholipase A2, group IIE	approved	Aminosalicylic Acid
DB01955	phospholipase A2, group IIE	experimental	1,4-Butanediol
DB02448	phospholipase A2, group IIE	experimental	N-Tridecanoic Acid
DB02636	phospholipase A2, group IIE	experimental	9-Hydroxy-8-Methoxy-6-Nitro-Phenanthrol[3,4-D][1,3]Dioxole-5-Carboxylic Acid
DB02758	phospholipase A2, group IIE	experimental	Indolylpropionic Acid
DB02795	phospholipase A2, group IIE	experimental	P-Anisic Acid
DB03585	phospholipase A2, group IIE	experimental; withdrawn	Oxyphenbutazone
DB04077	phospholipase A2, group IIE	experimental	Glycerol
DB04743	phospholipase A2, group IIE	experimental	Nimesulide
DB06987	phospholipase A2, group IIE	experimental	2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE
DB07500	phospholipase A2, group IIE	experimental	(2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
DB07950	phospholipase A2, group IIE	experimental	1H-INDOL-3-YLACETIC ACID
DB07958	phospholipase A2, group IIE	experimental	(2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID
DB08447	phospholipase A2, group IIE	experimental	3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL

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Cross referenced IDs for PLA2G2E

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information