Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for SCARB1

Basic gene info.	Gene symbol	SCARB1
	Gene name	scavenger receptor class B, member 1
	Synonyms	CD36L1\|CLA-1\|CLA1\|HDLQTL6\|SR-BI\|SRB1
	Cytomap	UCSC genome browser: 12q24.31
	Genomic location	chr12 :125262173-125348519
	Type of gene	protein-coding
	RefGenes	NM_001082959.1, NM_005505.4,
	Ensembl id	ENSG00000073060
	Description	CD36 and LIMPII analogous 1CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1scavenger receptor class B member 1scavenger receptor class B type III
	Modification date	20141207
dbXrefs	MIM : 601040
	HGNC : HGNC
	Ensembl : ENSG00000073060
	HPRD : 03024
	Vega : OTTHUMG00000168544
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SCARB1
	BioGPS: 949
	Gene Expression Atlas: ENSG00000073060
	The Human Protein Atlas: ENSG00000073060
Pathway	NCI Pathway Interaction Database: SCARB1
	KEGG: SCARB1
	REACTOME: SCARB1
	ConsensusPathDB
	Pathway Commons: SCARB1
Metabolism	MetaCyc: SCARB1
	HUMANCyc: SCARB1
Regulation	Ensembl's Regulation: ENSG00000073060
	miRBase: chr12 :125,262,173-125,348,519
	TargetScan: NM_001082959
	cisRED: ENSG00000073060
Context	iHOP: SCARB1
	cancer metabolism search in PubMed: SCARB1
	UCL Cancer Institute: SCARB1
Assigned class in ccmGDB	C

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Phenotypic Information for SCARB1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: SCARB1
	Familial Cancer Database: SCARB1

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS REACTOME_LIPOPROTEIN_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: SCARB1
	MedGen: SCARB1 (Human Medical Genetics with Condition)
	ClinVar: SCARB1
Phenotype	MGI: SCARB1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: SCARB1

Mutations for SCARB1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
ovary	SCARB1	chr12	125337464	125337484		chr12	126225424	126225444

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SCARB1 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
AI123607	ROBO3	27	152	11	124751231	124751356	SCARB1	149	266	12	125262885	125263002
CB115292	SCARB1	2	363	12	125262716	125263077	UBC	364	490	12	125396192	125396318

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=42)	Stat. for Synonymous SNVs (# total SNVs=12)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr12:125284671-125284671	p.P376L	2
chr12:125302181-125302181	p.V67I	2
chr12:125284748-125284748	p.A350A	2
chr12:125284769-125284769	p.S343S	2
chr12:125294788-125294788	p.S258S	2
chr12:125294816-125294816	p.D249G	2
chr12:125348263-125348263	p.G2S	2
chr12:125298827-125298827	p.K184R	2
chr12:125292364-125292364	p.E318K	2
chr12:125298921-125298921	p.M153V	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	2	1	10	2				2		1	3	4		1	1	2	5		4
# mutation	1	2	1	10	2				2		1	3	4		1	1	2	5		6
nonsynonymous SNV		2		5					2		1	3	3			1	2	4		6
synonymous SNV	1		1	5	2								1		1			1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr12:125292364	p.Y446Y,SCARB1	2
chr12:125270966	p.V44M,SCARB1	2
chr12:125302250	p.S343S,SCARB1	2
chr12:125284769	p.E318K,SCARB1	2
chr12:125284785	p.F245F,SCARB1	1
chr12:125298774	p.D47N,SCARB1	1
chr12:125302175	p.V447I,SCARB1	1
chr12:125267275	p.L240L,SCARB1	1
chr12:125292347	p.R45H,SCARB1	1
chr12:125298775	p.L218F,SCARB1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for SCARB1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SCARB1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AADAC,C1orf141,FOXL2NB,MGARP,CELA2A,CYP11A1,CYP17A1, CYP19A1,FSHR,HSD3B1,INHA,INSL3,KLHL4,LHCGR, MBOAT4,MRO,REG3G,SCARB1,STAR,TCF21,TREML5P	ACVRL1,AVPR2,C10orf54,CCM2L,CCL14,CLDN15,ENG, HLX,ICAM2,MFNG,MFRP,NDUFA4L2,NOVA2,PLAC9, PLVAP,RASIP1,SCARB1,SEMA6B,SH2D3C,TNFRSF1B,TTLL10

ACE2,AIFM1,CEBPA,DDX54,DHCR7,DHX37,HNF1A, MMAB,MVK,NSDHL,PPM1H,PPP1R14D,PRDM4,PUS1, PVR,SCARB1,SLC11A2,SLC39A5,SLC5A6,SPPL3,VIL1	ATP6AP1,CACFD1,CES3,DGCR2,FOXD2,GRAMD4,GRN, KIAA0195,LOC283070,LRP4,MUC20,MYO1D,PADI2,PHKA2, PIGZ,PTPRF,RIN1,SCARB1,SLC8B1,SLC26A6,TSPAN7

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SCARB1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00144	scavenger receptor class B, member 1	approved; nutraceutical	Phosphatidylserine
DB01039	scavenger receptor class B, member 1	approved	Fenofibrate
DB00334	scavenger receptor class B, member 1	approved; investigational	Olanzapine

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Cross referenced IDs for SCARB1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information