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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SLC25A15 |
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Phenotypic Information for SLC25A15(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: SLC25A15 |
Familial Cancer Database: SLC25A15 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Mutations for SLC25A15 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SLC25A15 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BM723940 | SLC25A15 | 1 | 295 | 13 | 41386156 | 41386451 | COL1A1 | 288 | 357 | 17 | 48261499 | 48261568 | |
DA750008 | CACNA1E | 131 | 152 | 1 | 181579601 | 181579622 | SLC25A15 | 137 | 568 | 13 | 41381430 | 41383781 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
LOSS (# sample) | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=25) | (# total SNVs=3) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr13:41373193-41373193 | p.G19E | 2 |
chr13:41381542-41381542 | p.G189C | 2 |
chr13:41379378-41379378 | p.A147T | 2 |
chr13:41381513-41381513 | p.R179Q | 1 |
chr13:41382658-41382658 | p.R236K | 1 |
chr13:41379289-41379289 | p.S117Y | 1 |
chr13:41381530-41381532 | p.F188delF | 1 |
chr13:41382711-41382711 | p.I254L | 1 |
chr13:41379327-41379327 | p.V130M | 1 |
chr13:41373228-41373228 | p.D31H | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 2 |   |   |   |   | 1 |   |   | 1 | 2 | 1 |   |   | 1 | 3 |   | 9 |
# mutation | 1 | 1 |   | 2 |   |   |   |   | 1 |   |   | 1 | 2 | 1 |   |   | 1 | 3 |   | 11 |
nonsynonymous SNV | 1 | 1 |   | 2 |   |   |   |   | 1 |   |   | 1 | 2 | 1 |   |   |   | 1 |   | 8 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 2 |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr13:41381542 | p.A147T | 2 |
chr13:41379378 | p.G189C | 2 |
chr13:41382725 | p.D205G | 1 |
chr13:41381479 | p.E206G | 1 |
chr13:41383755 | p.D31H | 1 |
chr13:41373228 | p.V210I | 1 |
chr13:41373280 | p.T48I | 1 |
chr13:41381547 | p.P211S | 1 |
chr13:41373296 | p.K53N | 1 |
chr13:41381560 | p.A226A | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SLC25A15 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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PROSER1,MZT1,CKAP2,COG3,DIS3,KBTBD6,KBTBD7, GPALPP1,MED4,MRPS31,MTRF1,NAA16,NDFIP2,NUDT15, NUFIP1,NUPL1,RCBTB1,RNF219,SLC25A15,SUCLA2,WBP4 | C2orf15,ESRP1,FBXO16,GPR98,IGSF3,KDM1A,KIAA1324, KIAA1549,MYO5B,NAA40,NSUN7,SHROOM3,SLC12A8,SLC25A15, SMARCC1,SPATS2,SSX2IP,SYT7,THSD4,TOM1L1,ZNF544 | ||||
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ALG5,SPRYD7,BORA,CKAP2,DIS3,EXOSC8,GTF2F2, HMGB1,IPO5,GPALPP1,KPNA3,MRPS31,NAA16,NUFIP1, PCID2,RFC3,RNASEH2B,SKA3,SLC25A15,TFDP1,UCHL3 | AQP3,TMEM252,CLCN1,CLDN2,CRIP1,DAK,DDC, F11,FBP1,GATA5,GCHFR,HACL1,HTR1D,LOC201651, MS4A15,NR0B2,OTC,SLC25A15,TMEM41A,TMEM92,ZNF488 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for SLC25A15 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00129 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | approved; nutraceutical | L-Ornithine | ![]() | ![]() |
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Cross referenced IDs for SLC25A15 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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