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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for CDK8 |
Basic gene info. | Gene symbol | CDK8 |
Gene name | cyclin-dependent kinase 8 | |
Synonyms | K35 | |
Cytomap | UCSC genome browser: 13q12 | |
Genomic location | chr13 :26828755-26978569 | |
Type of gene | protein-coding | |
RefGenes | NM_001260.1, | |
Ensembl id | ENSG00000132964 | |
Description | CDK8 protein kinasecell division protein kinase 8mediator complex subunit CDK8mediator of RNA polymerase II transcription subunit CDK8protein kinase K35 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603184 | |
HGNC : HGNC | ||
Ensembl : ENSG00000132964 | ||
HPRD : 04422 | ||
Vega : OTTHUMG00000016617 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDK8 | |
BioGPS: 1024 | ||
Gene Expression Atlas: ENSG00000132964 | ||
The Human Protein Atlas: ENSG00000132964 | ||
Pathway | NCI Pathway Interaction Database: CDK8 | |
KEGG: CDK8 | ||
REACTOME: CDK8 | ||
ConsensusPathDB | ||
Pathway Commons: CDK8 | ||
Metabolism | MetaCyc: CDK8 | |
HUMANCyc: CDK8 | ||
Regulation | Ensembl's Regulation: ENSG00000132964 | |
miRBase: chr13 :26,828,755-26,978,569 | ||
TargetScan: NM_001260 | ||
cisRED: ENSG00000132964 | ||
Context | iHOP: CDK8 | |
cancer metabolism search in PubMed: CDK8 | ||
UCL Cancer Institute: CDK8 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for CDK8(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: CDK8 |
Familial Cancer Database: CDK8 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: CDK8 |
MedGen: CDK8 (Human Medical Genetics with Condition) | |
ClinVar: CDK8 | |
Phenotype | MGI: CDK8 (International Mouse Phenotyping Consortium) |
PhenomicDB: CDK8 |
Mutations for CDK8 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
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- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | CDK8 | chr13 | 26877726 | 26877746 | CDK8 | chr13 | 26873549 | 26873569 |
ovary | CDK8 | chr13 | 26877903 | 26877923 | CDK8 | chr13 | 26878218 | 26878238 |
ovary | CDK8 | chr13 | 26922901 | 26922921 | CDK8 | chr13 | 26922965 | 26922985 |
pancreas | CDK8 | chr13 | 26834343 | 26834363 | IL1RAPL1 | chr23 | 29617847 | 29617867 |
pancreas | CDK8 | chr13 | 26855754 | 26855774 | CDK8 | chr13 | 26855694 | 26855714 |
pancreas | CDK8 | chr13 | 26964711 | 26964731 | CDK8 | chr13 | 26964929 | 26964949 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CDK8 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
M78127 | PACS1 | 1 | 130 | 11 | 66010673 | 66010802 | CDK8 | 131 | 372 | 13 | 26966520 | 26966760 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   | 6 |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   | 6 |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=55) | (# total SNVs=11) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr13:26959411-26959411 | p.V193G | 3 |
chr13:26967533-26967533 | p.E226* | 2 |
chr13:26978149-26978149 | p.Q442H | 2 |
chr13:26923267-26923267 | p.H88R | 2 |
chr13:26828880-26828880 | p.H34H | 1 |
chr13:26959398-26959398 | p.D189N | 1 |
chr13:26975623-26975623 | p.Q377H | 1 |
chr13:26923311-26923311 | p.D103N | 1 |
chr13:26967576-26967576 | p.D240G | 1 |
chr13:26956961-26956961 | p.N156I | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 5 | 1 | 1 | 9 |   |   | 6 |   | 4 |   |   | 7 | 3 | 1 |   |   | 5 |   |   | 5 |
# mutation | 5 | 1 | 1 | 10 |   |   | 6 |   | 4 |   |   | 8 | 3 | 1 |   |   | 5 |   |   | 5 |
nonsynonymous SNV | 4 | 1 |   | 7 |   |   | 5 |   | 3 |   |   | 6 | 2 | 1 |   |   | 3 |   |   | 3 |
synonymous SNV | 1 |   | 1 | 3 |   |   | 1 |   | 1 |   |   | 2 | 1 |   |   |   | 2 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr13:26911747 | p.I59I | 1 |
chr13:26971323 | p.A155V | 1 |
chr13:26927911 | p.D305N | 1 |
chr13:26978095 | p.S60P | 1 |
chr13:26959390 | p.G163G | 1 |
chr13:26911752 | p.T325T | 1 |
chr13:26971342 | p.A63T | 1 |
chr13:26927935 | p.E165Q | 1 |
chr13:26978103 | p.Q331H | 1 |
chr13:26959424 | p.R65K | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for CDK8 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ADAM17,ANAPC1,BRCA2,PROSER1,CDK8,CENPJ,GPR180, KPNA3,MSH2,NUPL1,PATL1,RNF6,SKA3,SLC7A1, SRPK1,SUV39H2,USP12,WDR43,XPO1,XPO4,ZDHHC20 | ARHGAP42,BAG4,GID4,CDK8,COL4A3BP,DDHD1,DDHD2, DLG1,DYNC1LI2,FBXW2,KCTD20,KIAA0922,LARP1,PIK3CA, PTPN4,R3HDM1,SEC22B,SNX19,TRIP12,VTI1A,XPOT | ||||
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CDK8,CENPJ,DIS3,MICU2,ELF1,SUPT20H,IPO5, GPALPP1,KPNA3,LNX2,MTMR6,NAA16,NUFIP1,NUPL1, PAN3,PDS5B,POLR1D,RNF219,RNF6,SLC25A15,XPO4 | BGLAP,C10orf107,CARTPT,CBR3,CDK8,COX7A1,HCFC2, KCNMB2,LAPTM4A,MANBAL,MORF4L1,NEK7,NGB,NXPH2, PCP4,PHKG1,RHEB,RIT2,S100B,VAMP5,WNT16 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for CDK8 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB03496 | cyclin-dependent kinase 8 | experimental; investigational | Flavopiridol | ![]() | ![]() |
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Cross referenced IDs for CDK8 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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