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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for WARS2 |
Basic gene info. | Gene symbol | WARS2 |
Gene name | tryptophanyl tRNA synthetase 2, mitochondrial | |
Synonyms | TrpRS | |
Cytomap | UCSC genome browser: 1p12 | |
Genomic location | chr1 :119573838-119683295 | |
Type of gene | protein-coding | |
RefGenes | NM_015836.3, NM_201263.2, | |
Ensembl id | ENSG00000116874 | |
Description | (Mt)TrpRStryptophan tRNA ligase 2, mitochondrialtryptophan--tRNA ligase, mitochondrialtryptophan-tRNA ligasetryptophanyl-tRNA synthetase, mitochondrial | |
Modification date | 20141207 | |
dbXrefs | MIM : 604733 | |
HGNC : HGNC | ||
Ensembl : ENSG00000116874 | ||
HPRD : 05295 | ||
Vega : OTTHUMG00000012335 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WARS2 | |
BioGPS: 10352 | ||
Gene Expression Atlas: ENSG00000116874 | ||
The Human Protein Atlas: ENSG00000116874 | ||
Pathway | NCI Pathway Interaction Database: WARS2 | |
KEGG: WARS2 | ||
REACTOME: WARS2 | ||
ConsensusPathDB | ||
Pathway Commons: WARS2 | ||
Metabolism | MetaCyc: WARS2 | |
HUMANCyc: WARS2 | ||
Regulation | Ensembl's Regulation: ENSG00000116874 | |
miRBase: chr1 :119,573,838-119,683,295 | ||
TargetScan: NM_015836 | ||
cisRED: ENSG00000116874 | ||
Context | iHOP: WARS2 | |
cancer metabolism search in PubMed: WARS2 | ||
UCL Cancer Institute: WARS2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for WARS2(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: WARS2 |
Familial Cancer Database: WARS2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_TRYPTOPHAN_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: WARS2 |
MedGen: WARS2 (Human Medical Genetics with Condition) | |
ClinVar: WARS2 | |
Phenotype | MGI: WARS2 (International Mouse Phenotyping Consortium) |
PhenomicDB: WARS2 |
Mutations for WARS2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | WARS2 | chr1 | 119624293 | 119624313 | WARS2 | chr1 | 119619393 | 119619413 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows WARS2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AI672033 | VAV3 | 1 | 335 | 1 | 108417521 | 108507503 | WARS2 | 332 | 459 | 1 | 119584927 | 119588287 | |
AK294729 | WARS2 | 1 | 403 | 1 | 119683014 | 119683416 | RYR2 | 401 | 1309 | 1 | 237850752 | 237872179 | |
DA579087 | WARS2 | 3 | 239 | 1 | 119683040 | 119683276 | LOXL2 | 240 | 580 | 8 | 23190983 | 23198691 | |
DC320785 | WARS2 | 1 | 403 | 1 | 119683014 | 119683416 | RYR2 | 401 | 557 | 1 | 237850752 | 237863571 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 5 |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) | 5 |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=14) | (# total SNVs=9) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:119576827-119576827 | p.H175H | 2 |
chr1:119584928-119584928 | p.L158L | 2 |
chr1:119619117-119619117 | p.S68S | 2 |
chr1:119576809-119576809 | p.D181D | 1 |
chr1:119588254-119588254 | p.L127P | 1 |
chr1:119619185-119619185 | p.I46V | 1 |
chr1:119576822-119576822 | p.P177L | 1 |
chr1:119619004-119619004 | p.P106L | 1 |
chr1:119619219-119619219 | p.K34N | 1 |
chr1:119619015-119619015 | p.C102C | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 11 |   |   | 4 |   | 3 |   |   | 6 | 3 | 1 |   | 1 | 6 | 9 |   | 4 |
# mutation |   |   |   | 10 |   |   | 4 |   | 3 |   |   | 11 | 3 | 1 |   | 1 | 6 | 9 |   | 4 |
nonsynonymous SNV |   |   |   | 7 |   |   | 4 |   | 2 |   |   | 8 | 2 | 1 |   |   | 4 | 7 |   | 3 |
synonymous SNV |   |   |   | 3 |   |   |   |   | 1 |   |   | 3 | 1 |   |   | 1 | 2 | 2 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:119575743 | p.P316R | 2 |
chr1:119575670 | p.D75G,WARS2 | 2 |
chr1:119619097 | p.A295A | 2 |
chr1:119575732 | p.R292C | 2 |
chr1:119575582 | p.L345L | 1 |
chr1:119576827 | p.V272M | 1 |
chr1:119575733 | p.L158L,WARS2 | 1 |
chr1:119619185 | p.E344G | 1 |
chr1:119575893 | p.R269C | 1 |
chr1:119575584 | p.G153D,WARS2 | 1 |
Other DBs for Point Mutations |
Copy Number for WARS2 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for WARS2 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ATP1A1,BPI,ATP1A1-AS1,CD58,CNTN6,CTNND1,GDAP2, IGSF3,MDGA2,NCALD,NOTCH2,PHGDH,SEC22B,SLC39A12, SLC43A3,SPON1,STAC2,VTCN1,WARS2,WDR3,ZNF697 | AASDHPPT,C11orf57,URI1,TMA16,CNOT7,DARS,EIF2A, EIF2S3,EIF3E,MAT2B,MBLAC2,NUP54,POC1B,RSL24D1, TMEM69,TRMT5,WARS2,ZCCHC7,ZFAND1,ZNF22,ZNF277 | ||||
ATP5F1,ATPAF2,C1QBP,CCBL2,COX5A,DPH5,LAMTOR5, MMACHC,MRPL1,MRPL37,MRPL44,MRPS27,OXSM,PCCB, PPA2,RPL5,SERBP1,TTC19,TXN2,UQCRH,WARS2 | ADH1C,AGPAT5,ALDH3A1,ALDH7A1,MPLKIP,DTWD2,LRPPRC, MARS2,MRPS30,NDUFA10,PCCA,PIGU,PTDSS1,PTGER2, RNMTL1,RPIA,SEH1L,SERPINA6,SHQ1,TGIF1,WARS2 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for WARS2 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00150 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Tryptophan | ||
DB00145 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | Glycine | ||
DB00160 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Alanine | ||
DB00125 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Arginine | ||
DB00151 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Cysteine | ||
DB00130 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical; investigational | L-Glutamine | ||
DB00117 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Histidine | ||
DB00149 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Leucine | ||
DB00123 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Lysine | ||
DB00134 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Methionine | ||
DB00120 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Phenylalanine | ||
DB00133 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Serine | ||
DB00156 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Threonine | ||
DB00135 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Tyrosine | ||
DB00161 | tryptophanyl tRNA synthetase 2, mitochondrial | approved; nutraceutical | L-Valine |
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Cross referenced IDs for WARS2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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