Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CDIPT
Basic gene info.Gene symbolCDIPT
Gene nameCDP-diacylglycerol--inositol 3-phosphatidyltransferase
SynonymsPIS|PIS1
CytomapUCSC genome browser: 16p11.2
Genomic locationchr16 :29869677-29874578
Type of geneprotein-coding
RefGenesNM_001286585.1,
NM_001286586.1,NM_006319.4,NM_145752.1,
Ensembl idENSG00000103502
DescriptionPI synthasePtdIns synthasephosphatidylinositol synthase
Modification date20141207
dbXrefs MIM : 605893
HGNC : HGNC
Ensembl : ENSG00000103502
HPRD : 12063
Vega : OTTHUMG00000177144
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CDIPT
BioGPS: 10423
Gene Expression Atlas: ENSG00000103502
The Human Protein Atlas: ENSG00000103502
PathwayNCI Pathway Interaction Database: CDIPT
KEGG: CDIPT
REACTOME: CDIPT
ConsensusPathDB
Pathway Commons: CDIPT
MetabolismMetaCyc: CDIPT
HUMANCyc: CDIPT
RegulationEnsembl's Regulation: ENSG00000103502
miRBase: chr16 :29,869,677-29,874,578
TargetScan: NM_001286585
cisRED: ENSG00000103502
ContextiHOP: CDIPT
cancer metabolism search in PubMed: CDIPT
UCL Cancer Institute: CDIPT
Assigned class in ccmGDBC

Top
Phenotypic Information for CDIPT(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CDIPT
Familial Cancer Database: CDIPT
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_INOSITOL_PHOSPHATE_METABOLISM
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM
REACTOME_PHOSPHOLIPID_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: CDIPT
MedGen: CDIPT (Human Medical Genetics with Condition)
ClinVar: CDIPT
PhenotypeMGI: CDIPT (International Mouse Phenotyping Consortium)
PhenomicDB: CDIPT

Mutations for CDIPT
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CDIPT related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=10)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr16:29872447-29872447p.S104S2
chr16:29874031-29874031p.R18R1
chr16:29871964-29871964p.E118Q1
chr16:29872462-29872462p.S99S1
chr16:29870521-29870521p.K211E1
chr16:29872497-29872497p.P88S1
chr16:29870555-29870555p.R199R1
chr16:29872528-29872528p.M77I1
chr16:29870565-29870565p.T196M1
chr16:29872573-29872573p.R62R1

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 1  1    2  1  1 3
# mutation 1 1  1    2  1  1 3
nonsynonymous SNV      1    1     1 1
synonymous SNV 1 1       1  1    2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:29874016p.G82W,CDIPT1
chr16:29874031p.E73Q,CDIPT1
chr16:29870555p.S54S,CDIPT1
chr16:29871937p.M32I,CDIPT1
chr16:29871964p.F18I,CDIPT1
chr16:29872462p.L46L1
chr16:29872528p.C31C1
chr16:29872572p.I23I1
chr16:29873949p.R18R1
chr16:29873992p.R154R,CDIPT1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CDIPT in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for CDIPT

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ARMC5,BCKDK,PAGR1,C16orf58,CCDC101,CD2BP2,CDIPT,
FBRS,FLYWCH2,HAGH,HIRIP3,INO80E,KCTD13,MAPK3,
PRR14,TBC1D10B,TMEM219,TUFM,YPEL3,ZNF688,ZNF768
AIP,BAD,C19orf43,LAMTOR4,CDIPT,CHMP4A,CTDSP1,
FAM195B,FKBP8,GNPTG,HTRA2,OCEL1,RABAC1,RANGRF,
RNASEK,RNF181,TMEM219,TNFSF12,VKORC1,ZNF358,ZNHIT1

C16orf58,CD2BP2,CDIPT,CLCN7,DYNLRB1,FBRS,HDAC5,
INO80E,LRRC29,KAT8,NSMCE1,ORAI3,PARN,PRR14,
SPNS1,SPSB3,STX4,YPEL3,ZNF213,ZNF646,ZNF688
ABTB1,AGPAT1,CCDC101,CDIPT,CTDSP1,DYRK1B,FOXO4,
HDAC11,HDAC5,HS1BP3,NFKBIL1,NR1H2,ORAI3,PDK2,
TBC1D13,UBXN6,WBP2,WDTC1,WIPI2,YPEL3,ZNF358
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for CDIPT
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB03106CDP-diacylglycerol--inositol 3-phosphatidyltransferaseexperimentalMyo-Inositol


Top
Cross referenced IDs for CDIPT
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas