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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PAIP1 |
Basic gene info. | Gene symbol | PAIP1 |
Gene name | poly(A) binding protein interacting protein 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 5p12 | |
Genomic location | chr5 :43526369-43557195 | |
Type of gene | protein-coding | |
RefGenes | NM_006451.4, NM_182789.3,NM_183323.2, | |
Ensembl id | ENSG00000172239 | |
Description | PABC1-interacting protein 1PABP-interacting protein 1PAIP-1poly(A)-binding protein-interacting protein 1polyadenylate binding protein-interacting protein 1polyadenylate-binding protein-interacting protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605184 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172239 | ||
HPRD : 05539 | ||
Vega : OTTHUMG00000096960 | ||
Protein | UniProt: Q9H074 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PAIP1 | |
BioGPS: 10605 | ||
Gene Expression Atlas: ENSG00000172239 | ||
The Human Protein Atlas: ENSG00000172239 | ||
Pathway | NCI Pathway Interaction Database: PAIP1 | |
KEGG: PAIP1 | ||
REACTOME: PAIP1 | ||
ConsensusPathDB | ||
Pathway Commons: PAIP1 | ||
Metabolism | MetaCyc: PAIP1 | |
HUMANCyc: PAIP1 | ||
Regulation | Ensembl's Regulation: ENSG00000172239 | |
miRBase: chr5 :43,526,369-43,557,195 | ||
TargetScan: NM_006451 | ||
cisRED: ENSG00000172239 | ||
Context | iHOP: PAIP1 | |
cancer metabolism search in PubMed: PAIP1 | ||
UCL Cancer Institute: PAIP1 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for PAIP1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: PAIP1 |
Familial Cancer Database: PAIP1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in BLCA 6, |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 6 http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12965.html, 7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | 605184; gene. |
Orphanet | |
Disease | KEGG Disease: PAIP1 |
MedGen: PAIP1 (Human Medical Genetics with Condition) | |
ClinVar: PAIP1 | |
Phenotype | MGI: PAIP1 (International Mouse Phenotyping Consortium) |
PhenomicDB: PAIP1 |
Mutations for PAIP1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PAIP1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BU734173 | HSP90AA1 | 15 | 282 | 14 | 102550822 | 102551205 | PAIP1 | 278 | 657 | 5 | 43535707 | 43543212 | |
BM709680 | PAIP1 | 1 | 381 | 5 | 43535707 | 43543212 | HSP90AA1 | 377 | 644 | 14 | 102550822 | 102551205 | |
BU732881 | HSP90AA1 | 15 | 282 | 14 | 102550822 | 102551205 | PAIP1 | 278 | 553 | 5 | 43535707 | 43539139 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=34) | (# total SNVs=8) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr5:43556069-43556069 | p.S100A | 2 |
chr5:43543182-43543182 | p.R220C | 2 |
chr5:43527537-43527537 | p.E461Q | 2 |
chr5:43543191-43543191 | p.M217V | 2 |
chr5:43543175-43543175 | p.C222Y | 2 |
chr5:43543177-43543177 | p.L221L | 1 |
chr5:43529903-43529903 | p.S444F | 1 |
chr5:43547949-43547949 | p.H168Y | 1 |
chr5:43535703-43535703 | p.G338* | 1 |
chr5:43556029-43556029 | p.M113K | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 6 |   |   | 5 |   |   | 3 |   | 4 |   |   | 7 | 4 | 1 |   |   | 7 | 3 |   | 6 |
# mutation | 6 |   |   | 6 |   |   | 4 |   | 4 |   |   | 9 | 4 | 1 |   |   | 7 | 4 |   | 7 |
nonsynonymous SNV | 6 |   |   | 6 |   |   | 4 |   | 3 |   |   | 8 | 2 | 1 |   |   | 6 | 2 |   | 6 |
synonymous SNV |   |   |   |   |   |   |   |   | 1 |   |   | 1 | 2 |   |   |   | 1 | 2 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr5:43543182 | p.R220S,PAIP1 | 2 |
chr5:43543181 | p.D416N,PAIP1 | 1 |
chr5:43529903 | p.R220P,PAIP1 | 1 |
chr5:43547955 | p.F135I,PAIP1 | 1 |
chr5:43535710 | p.S407F,PAIP1 | 1 |
chr5:43556095 | p.V120V,PAIP1 | 1 |
chr5:43529910 | p.R475C,PAIP1 | 1 |
chr5:43548014 | p.L372L,PAIP1 | 1 |
chr5:43536967 | p.M217I,PAIP1 | 1 |
chr5:43527495 | p.V119A,PAIP1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PAIP1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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BRIX1,C5orf22,C5orf28,C5orf34,C5orf51,CCT5,DNAJC21, FASTKD3,GOLPH3,ICE1,MTMR12,NIPBL,NUP155,PAIP1, RAD1,DROSHA,SKP2,TARS,TRIP13,ZFR,ZNF131 | ARL5A,ATAD1,BTF3L4,URI1,CAPZA2,CCDC91,DNAJC24, EIF1AX,EIF2S1,FAM175B,ISCA1,MMADHC,NT5C3A,PAIP1, PPP1CC,PRKRA,RAB6A,UBE2V2,UCHL5,VBP1,VPS37A |
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BRIX1,C11orf58,C3orf38,C5orf28,CCT5,CENPQ,CRBN, FASTKD3,GOLPH3,GPN1,PAIP1,PCNP,RAD1,SUB1, TBPL1,TTC33,UBA3,WDR70,ZFR,ZNF131,ZNF627 | ARL1,BTF3L4,FAM204A,C11orf58,CWC15,SMIM11,GNG10, METTL5,MRPL33,NMD3,NSL1,PAIP1,PCNP,PIGY, PRKAG1,RSL24D1,RWDD1,SNX3,STARD3NL,ZCRB1,ZFAND1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for PAIP1 |
There's no related Drug. |
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Cross referenced IDs for PAIP1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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