Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CES1
Basic gene info.Gene symbolCES1
Gene namecarboxylesterase 1
SynonymsACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1
CytomapUCSC genome browser: 16q22.2
Genomic locationchr16 :55836763-55867075
Type of geneprotein-coding
RefGenesNM_001025194.1,
NM_001025195.1,NM_001266.4,
Ensembl idENSG00000262243
Descriptionacyl coenzyme A:cholesterol acyltransferaseacyl-coenzyme A:cholesterol acyltransferasebrain carboxylesterase hBr1carboxylesterase 1 (monocyte/macrophage serine esterase 1)carboxylesterase 2 (liver)cholesteryl ester hydrolasecocaine carboxylesterase
Modification date20141222
dbXrefs MIM : 114835
HGNC : HGNC
Ensembl : ENSG00000198848
HPRD : 00268
Vega : OTTHUMG00000176718
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CES1
BioGPS: 1066
Gene Expression Atlas: ENSG00000262243
The Human Protein Atlas: ENSG00000262243
PathwayNCI Pathway Interaction Database: CES1
KEGG: CES1
REACTOME: CES1
ConsensusPathDB
Pathway Commons: CES1
MetabolismMetaCyc: CES1
HUMANCyc: CES1
RegulationEnsembl's Regulation: ENSG00000262243
miRBase: chr16 :55,836,763-55,867,075
TargetScan: NM_001025194
cisRED: ENSG00000262243
ContextiHOP: CES1
cancer metabolism search in PubMed: CES1
UCL Cancer Institute: CES1
Assigned class in ccmGDBC

Top
Phenotypic Information for CES1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CES1
Familial Cancer Database: CES1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: CES1
MedGen: CES1 (Human Medical Genetics with Condition)
ClinVar: CES1
PhenotypeMGI: CES1 (International Mouse Phenotyping Consortium)
PhenomicDB: CES1

Mutations for CES1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CES1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BP241894CES11504165583748555846928H2AFY2504579107185107771851152

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample1         1      
GAIN (# sample)                 
LOSS (# sample)1         1      
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=0

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=0)
Stat. for Synonymous SNVs
(# total SNVs=0)
There's no ns-snv.There's no s-snv.
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 21132 4 6  932 1208 12
# mutation 22132 4 6  932 11910 15
nonsynonymous SNV 22122 3 5  621 1157 12
synonymous SNV   1  1 1  311  43 3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:55855282p.L230I,CES13
chr16:55857517p.E161K,CES13
chr16:55844493p.C87Y,CES12
chr16:55857555p.A222V,CES12
chr16:55860205p.S214F,CES12
chr16:55855305p.A148V,CES12
chr16:55853460p.R199C,CES12
chr16:55855329p.F417L,CES12
chr16:55855375p.T297M,CES12
chr16:55855389p.K36T,CES11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CES1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for CES1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AKR1B10,AKR1C1,ALDH3A1,CES1,CES1P1,CSH1,CSHL1,
DDX52,DUSP14,GPX2,HIST2H3C,HIST2H3D,LYZL4,PPP1R9B,
PSMD11,RBMXL2,SP2,SYNRG,UTP6,VCX,ZP1
AKR1C2,AKR1C3,BHMT2,CES1,DHDDS,EPB42,EPHX1,
FADS3,GCOM1,GLYAT,HSPA12A,ITIH5,ITPK1,LEP,
PMEPA1,PYGL,TK2,TNS3,TPST2,UCHL1,VLDLR

ABCC2,ATP4A,BCAM,C1orf64,CES1,CES1P1,CHRND,
EMID1,F2,GYPB,HHATL,HIST1H4G,IGDCC3,LCN12,
NAALADL1,NKD1,NOD2,OC90,OR6C68,PMFBP1,SNAR-F
ACTA2,BVES,CES1,CORO6,CTXN1,DACT3,FAM46B,
HRASLS5,ILDR2,KCNK3,KCNMB1,KCTD8,MPP2,NPTXR,
PDLIM7,PNCK,REEP2,TAGLN,TGFB1I1,TMEM35,TUBA1A
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for CES1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00198carboxylesterase 1approvedOseltamivir
DB00583carboxylesterase 1approvedL-Carnitine
DB01599carboxylesterase 1approvedProbucol
DB02161carboxylesterase 1experimentalHydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
DB02659carboxylesterase 1experimentalCholic Acid
DB02944carboxylesterase 1experimentalAlpha-D-Mannose
DB03056carboxylesterase 1experimental4-Piperidino-Piperidine
DB03721carboxylesterase 1experimentalO-Sialic Acid
DB04509carboxylesterase 1experimentalN-Methylnaloxonium
DB04795carboxylesterase 1experimentalThenoyltrifluoroacetone
DB04838carboxylesterase 1approvedCyclandelate
DB07821carboxylesterase 1experimental(1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE
DB08224carboxylesterase 1experimental(1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
DB00951carboxylesterase 1approvedIsoniazid
DB00422carboxylesterase 1approved; investigationalMethylphenidate
DB06209carboxylesterase 1approved; investigationalPrasugrel
DB01101carboxylesterase 1approved; investigationalCapecitabine
DB00544carboxylesterase 1approvedFluorouracil
DB00762carboxylesterase 1approved; investigationalIrinotecan
DB00519carboxylesterase 1approvedTrandolapril


Top
Cross referenced IDs for CES1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas