Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

Home

	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for CES1

Basic gene info.	Gene symbol	CES1
	Gene name	carboxylesterase 1
	Synonyms	ACAT\|CE-1\|CEH\|CES2\|HMSE\|HMSE1\|PCE-1\|REH\|SES1\|TGH\|hCE-1
	Cytomap	UCSC genome browser: 16q22.2
	Genomic location	chr16 :55836763-55867075
	Type of gene	protein-coding
	RefGenes	NM_001025194.1, NM_001025195.1,NM_001266.4,
	Ensembl id	ENSG00000262243
	Description	acyl coenzyme A:cholesterol acyltransferaseacyl-coenzyme A:cholesterol acyltransferasebrain carboxylesterase hBr1carboxylesterase 1 (monocyte/macrophage serine esterase 1)carboxylesterase 2 (liver)cholesteryl ester hydrolasecocaine carboxylesterase
	Modification date	20141222
dbXrefs	MIM : 114835
	HGNC : HGNC
	Ensembl : ENSG00000198848
	HPRD : 00268
	Vega : OTTHUMG00000176718
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CES1
	BioGPS: 1066
	Gene Expression Atlas: ENSG00000262243
	The Human Protein Atlas: ENSG00000262243
Pathway	NCI Pathway Interaction Database: CES1
	KEGG: CES1
	REACTOME: CES1
	ConsensusPathDB
	Pathway Commons: CES1
Metabolism	MetaCyc: CES1
	HUMANCyc: CES1
Regulation	Ensembl's Regulation: ENSG00000262243
	miRBase: chr16 :55,836,763-55,867,075
	TargetScan: NM_001025194
	cisRED: ENSG00000262243
Context	iHOP: CES1
	cancer metabolism search in PubMed: CES1
	UCL Cancer Institute: CES1
Assigned class in ccmGDB	C

Top

Phenotypic Information for CES1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: CES1
	Familial Cancer Database: CES1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

Others
OMIM
Orphanet
Disease	KEGG Disease: CES1
	MedGen: CES1 (Human Medical Genetics with Condition)
	ClinVar: CES1
Phenotype	MGI: CES1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: CES1

Mutations for CES1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CES1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

BP241894

CES1

504

55837485

55846928

H2AFY2

504

579

71851077

71851152

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

Top

Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top

SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=0

Top

Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=0)	Stat. for Synonymous SNVs (# total SNVs=0)
There's no ns-snv.	There's no s-snv.
Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

Top

Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position

Mutation(aa)

Unique sampleID count

Top

SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		2	1	13	2		4		6			9	3	2		1	20	8		12
# mutation		2	2	13	2		4		6			9	3	2		1	19	10		15
nonsynonymous SNV		2	2	12	2		3		5			6	2	1		1	15	7		12
synonymous SNV				1			1		1			3	1	1			4	3		3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top

Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr16:55855282	p.L230I,CES1	3
chr16:55857517	p.E161K,CES1	3
chr16:55860205	p.C87Y,CES1	2
chr16:55855305	p.A222V,CES1	2
chr16:55853460	p.S214F,CES1	2
chr16:55855329	p.A148V,CES1	2
chr16:55855375	p.R199C,CES1	2
chr16:55844493	p.F417L,CES1	2
chr16:55857555	p.T297M,CES1	2
chr16:55844438	p.G18V,CES1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for CES1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top

Gene Expression for CES1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

Top

CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

Top

Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AKR1B10,AKR1C1,ALDH3A1,CES1,CES1P1,CSH1,CSHL1, DDX52,DUSP14,GPX2,HIST2H3C,HIST2H3D,LYZL4,PPP1R9B, PSMD11,RBMXL2,SP2,SYNRG,UTP6,VCX,ZP1	AKR1C2,AKR1C3,BHMT2,CES1,DHDDS,EPB42,EPHX1, FADS3,GCOM1,GLYAT,HSPA12A,ITIH5,ITPK1,LEP, PMEPA1,PYGL,TK2,TNS3,TPST2,UCHL1,VLDLR

ABCC2,ATP4A,BCAM,C1orf64,CES1,CES1P1,CHRND, EMID1,F2,GYPB,HHATL,HIST1H4G,IGDCC3,LCN12, NAALADL1,NKD1,NOD2,OC90,OR6C68,PMFBP1,SNAR-F	ACTA2,BVES,CES1,CORO6,CTXN1,DACT3,FAM46B, HRASLS5,ILDR2,KCNK3,KCNMB1,KCTD8,MPP2,NPTXR, PDLIM7,PNCK,REEP2,TAGLN,TGFB1I1,TMEM35,TUBA1A

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

Top

Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top

Pharmacological Information for CES1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00198	carboxylesterase 1	approved	Oseltamivir
DB00583	carboxylesterase 1	approved	L-Carnitine
DB01599	carboxylesterase 1	approved	Probucol
DB02161	carboxylesterase 1	experimental	Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
DB02659	carboxylesterase 1	experimental	Cholic Acid
DB02944	carboxylesterase 1	experimental	Alpha-D-Mannose
DB03056	carboxylesterase 1	experimental	4-Piperidino-Piperidine
DB03721	carboxylesterase 1	experimental	O-Sialic Acid
DB04509	carboxylesterase 1	experimental	N-Methylnaloxonium
DB04795	carboxylesterase 1	experimental	Thenoyltrifluoroacetone
DB04838	carboxylesterase 1	approved	Cyclandelate
DB07821	carboxylesterase 1	experimental	(1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE
DB08224	carboxylesterase 1	experimental	(1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
DB00951	carboxylesterase 1	approved	Isoniazid
DB00422	carboxylesterase 1	approved; investigational	Methylphenidate
DB06209	carboxylesterase 1	approved; investigational	Prasugrel
DB01101	carboxylesterase 1	approved; investigational	Capecitabine
DB00544	carboxylesterase 1	approved	Fluorouracil
DB00762	carboxylesterase 1	approved; investigational	Irinotecan
DB00519	carboxylesterase 1	approved	Trandolapril

Top

Cross referenced IDs for CES1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information