Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for CCT8

Basic gene info.	Gene symbol	CCT8
	Gene name	chaperonin containing TCP1, subunit 8 (theta)
	Synonyms	C21orf112\|Cctq\|D21S246\|PRED71
	Cytomap	UCSC genome browser: 21q22.11
	Genomic location	chr21 :30428647-30446010
	Type of gene	protein-coding
	RefGenes	NM_001282907.1, NM_001282908.1,NM_001282909.1,NM_006585.3,
	Ensembl id	ENSG00000156261
	Description	CCT-thetaT-complex protein 1 subunit thetaTCP-1-thetarenal carcinoma antigen NY-REN-15
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000156261
	HPRD : 10816
	Vega : OTTHUMG00000044595
Protein	UniProt: P50990 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CCT8
	BioGPS: 10694
	Gene Expression Atlas: ENSG00000156261
	The Human Protein Atlas: ENSG00000156261
Pathway	NCI Pathway Interaction Database: CCT8
	KEGG: CCT8
	REACTOME: CCT8
	ConsensusPathDB
	Pathway Commons: CCT8
Metabolism	MetaCyc: CCT8
	HUMANCyc: CCT8
Regulation	Ensembl's Regulation: ENSG00000156261
	miRBase: chr21 :30,428,647-30,446,010
	TargetScan: NM_001282907
	cisRED: ENSG00000156261
Context	iHOP: CCT8
	cancer metabolism search in PubMed: CCT8
	UCL Cancer Institute: CCT8
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for CCT8(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: CCT8
	Familial Cancer Database: CCT8

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: CCT8
	MedGen: CCT8 (Human Medical Genetics with Condition)
	ClinVar: CCT8
Phenotype	MGI: CCT8 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: CCT8

Mutations for CCT8

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CCT8 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG991440	FBXO7	35	146	22	32888763	32888879	CCT8	139	236	21	30432926	30433614
DA276711	LOC100507412	2	156	?	112025	112179	CCT8	154	569	21	30439912	30445981

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=30)	Stat. for Synonymous SNVs (# total SNVs=13)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr21:30440001-30440001	p.I86T	2
chr21:30441747-30441747	p.L76L	2
chr21:30441831-30441831	p.?	2
chr21:30432976-30432976	p.E485D	2
chr21:30437428-30437428	p.?	2
chr21:30433625-30433625	p.K466N	2
chr21:30439902-30439902	p.L119R	2
chr21:30435686-30435686	p.I310V	2
chr21:30433672-30433672	p.A451T	2
chr21:30428850-30428850	p.G531G	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	2	1	6					3			2			1		1	3		5
# mutation	1	2	1	6					3			2			1		1	3		7
nonsynonymous SNV		2	1	2					2			2			1			3		4
synonymous SNV	1			4					1								1			3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr21:30432936	p.A415V,CCT8	1
chr21:30435690	p.E86K,CCT8	1
chr21:30441752	p.R377H,CCT8	1
chr21:30432959	p.N80N,CCT8	1
chr21:30435737	p.L329V,CCT8	1
chr21:30441792	p.A78T,CCT8	1
chr21:30432968	p.G322D,CCT8	1
chr21:30435800	p.L50M,CCT8	1
chr21:30442596	p.D320D,CCT8	1
chr21:30433674	p.E24Q,CCT8	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for CCT8 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for CCT8

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ATP5C1,ATP5J,MIS18A,CCNB1,CCT8,CDC25A,DBF4, DLGAP5,DONSON,FARSB,GART,MRPL39,NOP58,PDSS1, PSMG1,RAN,RRP1B,RWDD2B,SCAF4,TCP1,USP16	ACP1,BTF3,CCT4,CCT6A,CCT8,CLNS1A,COMMD3, COPZ1,DAP3,DENR,DPH5,FARSB,GTF2F2,HSP90AB1, MRPL3,NACA,NPM1,OLA1,PA2G4,RNF114,TMEM5

ATP5J,ATP5O,MIS18A,C21orf59,CCDC58,CCDC59,CCT2, CCT8,GART,HMGN1,MRPL1,MRPL39,MRPL42,MRPS6, NDUFV3,NPM1,NUP37,PSMG1,U2AF1,UBE2N,USP16	ALG8,C1QBP,CCT2,CCT5,CCT6A,CCT8,EIF4A1, EIF4A3,FAM136A,FARSB,HSPD1,IMMP1L,KIAA0391,MRPL3, NOL11,PAICS,PHB,PPIA,TMX2,UMPS,VRK1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for CCT8

There's no related Drug.

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Cross referenced IDs for CCT8

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information