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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for UGT2B11 |
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Phenotypic Information for UGT2B11(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: UGT2B11 |
Familial Cancer Database: UGT2B11 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_ASCORBATE_AND_ALDARATE_METABOLISM KEGG_STARCH_AND_SUCROSE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_OTHER_ENZYMES |
Mutations for UGT2B11 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT2B11 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=77) | (# total SNVs=18) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:70066197-70066197 | p.W517* | 4 |
chr4:70070294-70070294 | p.I388I | 4 |
chr4:70080140-70080140 | p.R101* | 3 |
chr4:70079956-70079956 | p.A162V | 3 |
chr4:70079874-70079874 | p.F189F | 3 |
chr4:70078427-70078427 | p.T245I | 2 |
chr4:70080155-70080155 | p.R96G | 2 |
chr4:70079942-70079942 | p.R167W | 2 |
chr4:70071286-70071286 | p.? | 2 |
chr4:70066376-70066376 | p.D458H | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 | 2 | 10 | 3 |   | 8 |   | 2 |   |   | 11 | 5 | 2 |   | 1 | 20 | 5 |   | 9 |
# mutation | 1 | 1 | 1 | 11 | 3 |   | 8 |   | 2 |   |   | 16 | 5 | 2 |   | 1 | 21 | 5 |   | 11 |
nonsynonymous SNV | 1 |   | 1 | 8 | 2 |   | 7 |   | 2 |   |   | 14 | 5 | 2 |   | 1 | 15 | 3 |   | 9 |
synonymous SNV |   | 1 |   | 3 | 1 |   | 1 |   |   |   |   | 2 |   |   |   |   | 6 | 2 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:70079874 | p.F189F | 4 |
chr4:70080232 | p.N322N | 2 |
chr4:70074105 | p.I388I | 2 |
chr4:70080096 | p.I115I | 2 |
chr4:70066279 | p.S490Y | 2 |
chr4:70066308 | p.A480A | 2 |
chr4:70079942 | p.F280L | 2 |
chr4:70078323 | p.R96G | 2 |
chr4:70079978 | p.R167R | 2 |
chr4:70080155 | p.S70Y | 2 |
Other DBs for Point Mutations |
Copy Number for UGT2B11 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for UGT2B11 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
AQP3,ARF4,AZGP1,CA2,CLDN2,HHIPL2,HIGD1A, MAGEB3,PON2,RPS27L,SCP2,SDR16C5,TAAR6,TMEM86A, TRH,UGT2B10,UGT2B11,UGT2B15,UGT2B28,UGT2B7,VSTM2L | ACSL3,ADAM2,ALOX15B,APOD,DHRS2,GUSB,HIST1H4H, HPGD,IDI1,NANOG,NAT2,PLA2G4E,PNLIPRP3,PPEF1, SERHL2,SERHL,SPINK8,SULT1C3,UGT2B10,UGT2B11,UGT2B28 |
AMPH,ARR3,CDH4,CNGA3,CYLC1,ELOVL2,FAM181B, GAD2,GSTA1,MYCN,MYCNOS,NNAT,P2RY4,PON1, SCARNA20,SERPINA12,SYNGR4,T,UGT2B11,UGT2B28,ZNF385B | ASB17,CELA2A,DAD1P1,HS3ST6,KRT81,KRTAP4-8,LOC728606, MLLT3,NPW,OTOP1,PP14571,RAB27A,REP15,SAGE1, SSTR2,TFF2,TFF3,TMEM128,TPSG1,TSPAN13,UGT2B11 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for UGT2B11 |
There's no related Drug. |
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Cross referenced IDs for UGT2B11 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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