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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DHRS4 |
Basic gene info. | Gene symbol | DHRS4 |
Gene name | dehydrogenase/reductase (SDR family) member 4 | |
Synonyms | CR|NRDR|PHCR|PSCD|SCAD-SRL|SDR-SRL|SDR25C1|SDR25C2 | |
Cytomap | UCSC genome browser: 14q11.2 | |
Genomic location | chr14 :24422964-24438488 | |
Type of gene | protein-coding | |
RefGenes | NM_001282987.1, NM_001282988.1,NM_001282989.1,NM_001282990.1,NM_001282991.1, NM_021004.3, | |
Ensembl id | ENSG00000157326 | |
Description | NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenaseNADPH-dependent retinol dehydrogenase/reductasedehydrogenase/reductase (SDR family) member 4 like 2Adehydrogenase/reductase SDR family member 4peroxisomal short-chain alcohol dehydrogenases | |
Modification date | 20141207 | |
dbXrefs | MIM : 611596 | |
HGNC : HGNC | ||
Ensembl : ENSG00000157326 | ||
HPRD : 07484 | ||
Vega : OTTHUMG00000028777 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DHRS4 | |
BioGPS: 10901 | ||
Gene Expression Atlas: ENSG00000157326 | ||
The Human Protein Atlas: ENSG00000157326 | ||
Pathway | NCI Pathway Interaction Database: DHRS4 | |
KEGG: DHRS4 | ||
REACTOME: DHRS4 | ||
ConsensusPathDB | ||
Pathway Commons: DHRS4 | ||
Metabolism | MetaCyc: DHRS4 | |
HUMANCyc: DHRS4 | ||
Regulation | Ensembl's Regulation: ENSG00000157326 | |
miRBase: chr14 :24,422,964-24,438,488 | ||
TargetScan: NM_001282987 | ||
cisRED: ENSG00000157326 | ||
Context | iHOP: DHRS4 | |
cancer metabolism search in PubMed: DHRS4 | ||
UCL Cancer Institute: DHRS4 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for DHRS4(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: DHRS4 |
Familial Cancer Database: DHRS4 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_RETINOL_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: DHRS4 |
MedGen: DHRS4 (Human Medical Genetics with Condition) | |
ClinVar: DHRS4 | |
Phenotype | MGI: DHRS4 (International Mouse Phenotyping Consortium) |
PhenomicDB: DHRS4 |
Mutations for DHRS4 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DHRS4 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=19) | (# total SNVs=8) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:24424420-24424420 | p.T102M | 5 |
chr14:24423007-24423007 | p.A4T | 2 |
chr14:24424346-24424346 | p.Q77Q | 2 |
chr14:24424255-24424255 | p.A47V | 2 |
chr14:24435598-24435598 | p.G213E | 1 |
chr14:24424292-24424292 | p.V59V | 1 |
chr14:24429163-24429163 | p.N120T | 1 |
chr14:24437993-24437993 | p.G250G | 1 |
chr14:24424296-24424297 | p.V61S | 1 |
chr14:24429180-24429180 | p.I126L | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   | 3 |   |   | 1 |   | 3 | 1 |   | 3 | 1 | 1 |   |   | 1 |   |   | 1 |
# mutation |   | 1 |   | 3 |   |   | 1 |   | 3 | 1 |   | 3 | 1 | 1 |   |   | 1 |   |   | 1 |
nonsynonymous SNV |   | 1 |   | 2 |   |   | 1 |   | 2 | 1 |   | 1 | 1 | 1 |   |   |   |   |   | 1 |
synonymous SNV |   |   |   | 1 |   |   |   |   | 1 |   |   | 2 |   |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:24424420 | p.A47V,DHRS4 | 2 |
chr14:24424255 | p.T102M,DHRS4 | 2 |
chr14:24424307 | p.T159N,DHRS4 | 1 |
chr14:24424404 | p.L166L,DHRS4 | 1 |
chr14:24435538 | p.G179E,DHRS4 | 1 |
chr14:24423018 | p.H182Y | 1 |
chr14:24435560 | p.L7L,DHRS4 | 1 |
chr14:24424246 | p.I44N,DHRS4 | 1 |
chr14:24435598 | p.F46F,DHRS4 | 1 |
chr14:24424253 | p.D55Y,DHRS4 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for DHRS4 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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C19orf24,CHCHD5,COQ4,DCXR,DHRS4,DHRS4L1,DHRS4L2, EDF1,ENDOG,EMC9,FKBP2,GSTZ1,MMAB,MPG, MRPL41,MRPL54,PHPT1,SDSL,SIL1,TP53TG1,UQCR11 | AUP1,AURKAIP1,ELP6,CHMP2A,DDRGK1,DHRS4,DHRS4L2, IDH3G,MEA1,MED11,MRPL28,NAA10,NUDC,PMVK, PSMD13,PSMD9,RAB1B,SPR,TEX264,TMEM147,TMEM187 | ||||
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C14orf166,C14orf2,CHCHD10,CHMP4A,CINP,DHRS4,DHRS4L1, DHRS4L2,ENDOG,MZT2B,EMC9,GLRX5,GSTZ1,HAUS4, MED11,NUDT8,OSGEP,PSMB5,PSMC1,RABGGTA,RPL36AL | ACY3,AKR1A1,CLDN15,CRIP1,CYP2J2,DAK,DDC, DHRS4L2,F11,FBP1,GCHFR,MMEL1,MS4A15,OTC, PRSS1,SLC25A15,SLC37A4,TIGD3,TMEM92,PRSS3P2,TTC36 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for DHRS4 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00162 | dehydrogenase/reductase (SDR family) member 4 | approved; nutraceutical | Vitamin A | ![]() | ![]() |
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Cross referenced IDs for DHRS4 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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