Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for INMT
Basic gene info.Gene symbolINMT
Gene nameindolethylamine N-methyltransferase
SynonymsTEMT
CytomapUCSC genome browser: 7p14.3
Genomic locationchr7 :30791750-30797218
Type of geneprotein-coding
RefGenesNM_001199219.1,
NM_006774.4,
Ensembl idENSG00000241644
Descriptionamine N-methyltransferasearomatic alkylamine N-methyltransferasearylamine N-methyltransferaseindolamine N-methyltransferasenicotine N-methyltransferasethioether S-methyltransferase
Modification date20141207
dbXrefs MIM : 604854
HGNC : HGNC
Ensembl : ENSG00000241644
HPRD : 06890
Vega : OTTHUMG00000167163
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_INMT
BioGPS: 11185
Gene Expression Atlas: ENSG00000241644
The Human Protein Atlas: ENSG00000241644
PathwayNCI Pathway Interaction Database: INMT
KEGG: INMT
REACTOME: INMT
ConsensusPathDB
Pathway Commons: INMT
MetabolismMetaCyc: INMT
HUMANCyc: INMT
RegulationEnsembl's Regulation: ENSG00000241644
miRBase: chr7 :30,791,750-30,797,218
TargetScan: NM_001199219
cisRED: ENSG00000241644
ContextiHOP: INMT
cancer metabolism search in PubMed: INMT
UCL Cancer Institute: INMT
Assigned class in ccmGDBC

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Phenotypic Information for INMT(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: INMT
Familial Cancer Database: INMT
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_TRYPTOPHAN_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: INMT
MedGen: INMT (Human Medical Genetics with Condition)
ClinVar: INMT
PhenotypeMGI: INMT (International Mouse Phenotyping Consortium)
PhenomicDB: INMT

Mutations for INMT
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows INMT related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=33)
Stat. for Synonymous SNVs
(# total SNVs=12)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:30795310-30795310p.S212F7
chr7:30795331-30795331p.E219G4
chr7:30795288-30795288p.M205V4
chr7:30791848-30791848p.D28N3
chr7:30795204-30795204p.R177C2
chr7:30793463-30793463p.R91W2
chr7:30793366-30793366p.T58T2
chr7:30795280-30795280p.P202L2
chr7:30795287-30795287p.Y204*2
chr7:30793497-30793497p.P102L2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 3 61 1 1  86  1145 2
# mutation 3 71 1 1  76  1125 3
nonsynonymous SNV 3 4    1  64  152 2
synonymous SNV   31 1    12   73 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:30795310p.S211F,INMT6
chr7:30793359p.G55V,INMT2
chr7:30793366p.T57T,INMT2
chr7:30793423p.S76S,INMT2
chr7:30795377p.P101P,INMT1
chr7:30793452p.Q233Q,INMT1
chr7:30791781p.P108T,INMT1
chr7:30795128p.L235I,INMT1
chr7:30795381p.L58L,INMT1
chr7:30793463p.N119K,INMT1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for INMT in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for INMT

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ARHGEF15,AVPR2,BMX,CCL14,CD34,CLEC14A,CXorf36,
ACKR1,EMCN,FXYD1,GPR146,INMT,LHFP,LRRC70,
MFAP4,MMRN2,PDE2A,S1PR1,SVEP1,TSPAN7,VWF
ACVRL1,BGN,C1S,CCM2L,CLEC14A,CPXM2,ELMO1,
ESAM,GDF10,GNAI2,GRK5,HYAL1,IGFBP7,INMT,
MFNG,MMRN2,PECAM1,PGM5,PLVAP,PTGIR,SERPING1

ABCA8,BHMT2,CDO1,FBLN5,FLRT2,FZD4,GPIHBP1,
GYPC,HSPB2,INMT,ITIH5,LHFP,LIFR,MGP,
MRAS,PALMD,PNMAL2,PODN,PTGER3,RBMS3,SLIT3
AKAP12,BRSK1,C15orf59,CADM3,CREB5,ECM2,FAIM2,
FNDC5,GDF1,GPR133,GRB10,INMT,ITPKB,LONRF2,
MMP17,MTUS2,NMNAT2,NTN1,PALM,RFX2,ZMAT4
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for INMT


There's no related Drug.
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Cross referenced IDs for INMT
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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