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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for INMT |
Basic gene info. | Gene symbol | INMT |
Gene name | indolethylamine N-methyltransferase | |
Synonyms | TEMT | |
Cytomap | UCSC genome browser: 7p14.3 | |
Genomic location | chr7 :30791750-30797218 | |
Type of gene | protein-coding | |
RefGenes | NM_001199219.1, NM_006774.4, | |
Ensembl id | ENSG00000241644 | |
Description | amine N-methyltransferasearomatic alkylamine N-methyltransferasearylamine N-methyltransferaseindolamine N-methyltransferasenicotine N-methyltransferasethioether S-methyltransferase | |
Modification date | 20141207 | |
dbXrefs | MIM : 604854 | |
HGNC : HGNC | ||
Ensembl : ENSG00000241644 | ||
HPRD : 06890 | ||
Vega : OTTHUMG00000167163 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_INMT | |
BioGPS: 11185 | ||
Gene Expression Atlas: ENSG00000241644 | ||
The Human Protein Atlas: ENSG00000241644 | ||
Pathway | NCI Pathway Interaction Database: INMT | |
KEGG: INMT | ||
REACTOME: INMT | ||
ConsensusPathDB | ||
Pathway Commons: INMT | ||
Metabolism | MetaCyc: INMT | |
HUMANCyc: INMT | ||
Regulation | Ensembl's Regulation: ENSG00000241644 | |
miRBase: chr7 :30,791,750-30,797,218 | ||
TargetScan: NM_001199219 | ||
cisRED: ENSG00000241644 | ||
Context | iHOP: INMT | |
cancer metabolism search in PubMed: INMT | ||
UCL Cancer Institute: INMT | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for INMT(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: INMT |
Familial Cancer Database: INMT |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_TRYPTOPHAN_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: INMT |
MedGen: INMT (Human Medical Genetics with Condition) | |
ClinVar: INMT | |
Phenotype | MGI: INMT (International Mouse Phenotyping Consortium) |
PhenomicDB: INMT |
Mutations for INMT |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows INMT related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=33) | (# total SNVs=12) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr7:30795310-30795310 | p.S212F | 7 |
chr7:30795331-30795331 | p.E219G | 4 |
chr7:30795288-30795288 | p.M205V | 4 |
chr7:30791848-30791848 | p.D28N | 3 |
chr7:30793423-30793423 | p.S77S | 2 |
chr7:30795204-30795204 | p.R177C | 2 |
chr7:30793463-30793463 | p.R91W | 2 |
chr7:30793366-30793366 | p.T58T | 2 |
chr7:30795280-30795280 | p.P202L | 2 |
chr7:30795287-30795287 | p.Y204* | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 3 |   | 6 | 1 |   | 1 |   | 1 |   |   | 8 | 6 |   |   | 1 | 14 | 5 |   | 2 |
# mutation |   | 3 |   | 7 | 1 |   | 1 |   | 1 |   |   | 7 | 6 |   |   | 1 | 12 | 5 |   | 3 |
nonsynonymous SNV |   | 3 |   | 4 |   |   |   |   | 1 |   |   | 6 | 4 |   |   | 1 | 5 | 2 |   | 2 |
synonymous SNV |   |   |   | 3 | 1 |   | 1 |   |   |   |   | 1 | 2 |   |   |   | 7 | 3 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr7:30795310 | p.S211F,INMT | 6 |
chr7:30793359 | p.S76S,INMT | 2 |
chr7:30793366 | p.G55V,INMT | 2 |
chr7:30793423 | p.T57T,INMT | 2 |
chr7:30791874 | p.I59F,INMT | 1 |
chr7:30795321 | p.G121S,INMT | 1 |
chr7:30793439 | p.A247D,INMT | 1 |
chr7:30795056 | p.P65L,INMT | 1 |
chr7:30791901 | p.K126K,INMT | 1 |
chr7:30795374 | p.S76F,INMT | 1 |
Other DBs for Point Mutations |
Copy Number for INMT in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for INMT |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ARHGEF15,AVPR2,BMX,CCL14,CD34,CLEC14A,CXorf36, ACKR1,EMCN,FXYD1,GPR146,INMT,LHFP,LRRC70, MFAP4,MMRN2,PDE2A,S1PR1,SVEP1,TSPAN7,VWF | ACVRL1,BGN,C1S,CCM2L,CLEC14A,CPXM2,ELMO1, ESAM,GDF10,GNAI2,GRK5,HYAL1,IGFBP7,INMT, MFNG,MMRN2,PECAM1,PGM5,PLVAP,PTGIR,SERPING1 |
ABCA8,BHMT2,CDO1,FBLN5,FLRT2,FZD4,GPIHBP1, GYPC,HSPB2,INMT,ITIH5,LHFP,LIFR,MGP, MRAS,PALMD,PNMAL2,PODN,PTGER3,RBMS3,SLIT3 | AKAP12,BRSK1,C15orf59,CADM3,CREB5,ECM2,FAIM2, FNDC5,GDF1,GPR133,GRB10,INMT,ITPKB,LONRF2, MMP17,MTUS2,NMNAT2,NTN1,PALM,RFX2,ZMAT4 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for INMT |
There's no related Drug. |
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Cross referenced IDs for INMT |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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