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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for RPL35 |
Basic gene info. | Gene symbol | RPL35 |
Gene name | ribosomal protein L35 | |
Synonyms | L35 | |
Cytomap | UCSC genome browser: 9q34.1 | |
Genomic location | chr9 :127620157-127624240 | |
Type of gene | protein-coding | |
RefGenes | NM_007209.3, | |
Ensembl id | ENSG00000136942 | |
Description | 60S ribosomal protein L35 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000136942 | ||
HPRD : 10200 | ||
Vega : OTTHUMG00000020659 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RPL35 | |
BioGPS: 11224 | ||
Gene Expression Atlas: ENSG00000136942 | ||
The Human Protein Atlas: ENSG00000136942 | ||
Pathway | NCI Pathway Interaction Database: RPL35 | |
KEGG: RPL35 | ||
REACTOME: RPL35 | ||
ConsensusPathDB | ||
Pathway Commons: RPL35 | ||
Metabolism | MetaCyc: RPL35 | |
HUMANCyc: RPL35 | ||
Regulation | Ensembl's Regulation: ENSG00000136942 | |
miRBase: chr9 :127,620,157-127,624,240 | ||
TargetScan: NM_007209 | ||
cisRED: ENSG00000136942 | ||
Context | iHOP: RPL35 | |
cancer metabolism search in PubMed: RPL35 | ||
UCL Cancer Institute: RPL35 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for RPL35(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: RPL35 |
Familial Cancer Database: RPL35 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: RPL35 |
MedGen: RPL35 (Human Medical Genetics with Condition) | |
ClinVar: RPL35 | |
Phenotype | MGI: RPL35 (International Mouse Phenotyping Consortium) |
PhenomicDB: RPL35 |
Mutations for RPL35 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPL35 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CA433490 | RPL35 | 16 | 136 | 9 | 127620162 | 127620282 | NOC2L | 134 | 542 | 1 | 892529 | 892937 | |
BF802262 | RPL35 | 26 | 252 | 9 | 127622505 | 127624236 | DIAPH1 | 247 | 336 | 5 | 140896140 | 140896229 | |
CN394906 | RPL35 | 6 | 120 | 9 | 127620167 | 127620281 | C1orf43 | 115 | 765 | 1 | 154184844 | 154193017 | |
AI682966 | IGFBP5 | 13 | 299 | 2 | 217536832 | 217537116 | RPL35 | 300 | 541 | 9 | 127622461 | 127624210 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=7) | (# total SNVs=3) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:127620293-127620293 | p.R92R | 1 |
chr9:127620295-127620295 | p.R92C | 1 |
chr9:127620299-127620299 | p.A90A | 1 |
chr9:127620318-127620318 | p.R84Q | 1 |
chr9:127620332-127620332 | p.K79N | 1 |
chr9:127620210-127620210 | p.A120G | 1 |
chr9:127620344-127620344 | p.G75G | 1 |
chr9:127620219-127620219 | p.R117Q | 1 |
chr9:127623766-127623766 | p.L24L | 1 |
chr9:127620225-127620225 | p.P115L | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 2 |   | 4 |   |   |   |   |   |   |   | 1 |   | 1 |   |   | 1 |   |   | 1 |
# mutation | 1 | 2 |   | 4 |   |   |   |   |   |   |   | 1 |   | 1 |   |   | 1 |   |   | 1 |
nonsynonymous SNV |   | 2 |   | 4 |   |   |   |   |   |   |   | 1 |   |   |   |   | 1 |   |   |   |
synonymous SNV | 1 |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:127620293 | p.R84Q | 1 |
chr9:127620318 | p.K79N | 1 |
chr9:127620332 | p.R56S | 1 |
chr9:127622518 | p.L24L | 1 |
chr9:127623766 | p.A120G | 1 |
chr9:127620210 | p.R117Q | 1 |
chr9:127620219 | p.P115L | 1 |
chr9:127620225 | p.R94R | 1 |
chr9:127620287 | p.R94P | 1 |
chr9:127620288 | p.R94W | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for RPL35 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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LOC152217,POLR2H,RPL11,RPL24,RPL27A,RPL31,RPL32, RPL35A,RPL36,RPL37,RPL37A,RPL6,RPLP2,RPS10, RPS15A,RPS18,RPS19,RPS2,RPS27A,RPS7,RPS8 | BTF3,RPL14,RPL22,RPL23A,RPL24,RPL30,RPL32, RPL34,RPL35A,RPL41,RPL5,RPL6,RPS15A,RPS23, RPS24,RPS27A,RPS29,RPS3A,RPS4X,RPS6,RPS7 |
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EEF1B2,RPL10A,RPL14,RPL15,RPL24,RPL29,RPL31, RPL32,RPL35A,RPL37A,RPL7A,RPS10,RPS11,RPS13, RPS14,RPS15A,RPS17,RPS18,RPS25,RPS27A,RPS6 | C12orf57,DPY30,EEF1A1,EEF1A1P9,FAU,PFDN5,RPL15, RPL24,RPL27A,RPL35,RPL35A,RPL41,RPL5,RPS10, RPS11,RPS13,RPS3A,RPS5,RPS6,RPS7,SNRPD2 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for RPL35 |
There's no related Drug. |
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Cross referenced IDs for RPL35 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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