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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for B4GALT7 |
Basic gene info. | Gene symbol | B4GALT7 |
Gene name | xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 | |
Synonyms | EDSP1|XGALT1|XGPT1 | |
Cytomap | UCSC genome browser: 5q35.2-q35.3 | |
Genomic location | chr5 :177027118-177037346 | |
Type of gene | protein-coding | |
RefGenes | NM_007255.2, | |
Ensembl id | ENSG00000027847 | |
Description | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7beta-1,4-GalTase 7beta-1,4-galactosyltransferase 7beta-1,4-galactosyltransferase VIIbeta4Gal-T7beta4GalT-VIIgalactosyltransfe | |
Modification date | 20141215 | |
dbXrefs | MIM : 604327 | |
HGNC : HGNC | ||
Ensembl : ENSG00000027847 | ||
HPRD : 05060 | ||
Vega : OTTHUMG00000130851 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_B4GALT7 | |
BioGPS: 11285 | ||
Gene Expression Atlas: ENSG00000027847 | ||
The Human Protein Atlas: ENSG00000027847 | ||
Pathway | NCI Pathway Interaction Database: B4GALT7 | |
KEGG: B4GALT7 | ||
REACTOME: B4GALT7 | ||
ConsensusPathDB | ||
Pathway Commons: B4GALT7 | ||
Metabolism | MetaCyc: B4GALT7 | |
HUMANCyc: B4GALT7 | ||
Regulation | Ensembl's Regulation: ENSG00000027847 | |
miRBase: chr5 :177,027,118-177,037,346 | ||
TargetScan: NM_007255 | ||
cisRED: ENSG00000027847 | ||
Context | iHOP: B4GALT7 | |
cancer metabolism search in PubMed: B4GALT7 | ||
UCL Cancer Institute: B4GALT7 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for B4GALT7(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: B4GALT7 |
Familial Cancer Database: B4GALT7 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_CARBOHYDRATES |
Mutations for B4GALT7 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows B4GALT7 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=15) | (# total SNVs=11) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr5:177031436-177031436 | p.E103K | 2 |
chr5:177031265-177031265 | p.L46L | 2 |
chr5:177035954-177035954 | p.R256H | 2 |
chr5:177031406-177031406 | p.H93N | 2 |
chr5:177034371-177034371 | p.M161T | 1 |
chr5:177036618-177036618 | p.V302V | 1 |
chr5:177031200-177031200 | p.G24A | 1 |
chr5:177031409-177031409 | p.R94C | 1 |
chr5:177034375-177034375 | p.H162H | 1 |
chr5:177036642-177036642 | p.L310L | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 3 |   |   | 1 |   |   |   |   |   | 1 | 1 |   |   | 1 | 2 |   | 4 |
# mutation | 1 | 1 |   | 3 |   |   | 1 |   |   |   |   |   | 1 | 1 |   |   | 1 | 2 |   | 4 |
nonsynonymous SNV | 1 |   |   | 1 |   |   |   |   |   |   |   |   |   | 1 |   |   |   | 2 |   | 4 |
synonymous SNV |   | 1 |   | 2 |   |   | 1 |   |   |   |   |   | 1 |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr5:177034458 | p.E106K | 1 |
chr5:177031200 | p.V110V | 1 |
chr5:177035584 | p.P113P | 1 |
chr5:177031305 | p.L190F | 1 |
chr5:177035954 | p.L190R | 1 |
chr5:177031311 | p.D228D | 1 |
chr5:177036573 | p.R256H | 1 |
chr5:177031345 | p.L287L | 1 |
chr5:177036618 | p.V302V | 1 |
chr5:177031391 | p.G24A | 1 |
Other DBs for Point Mutations |
Copy Number for B4GALT7 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for B4GALT7 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ALKBH7,ARL6IP4,B4GALT7,BCL7C,TSR3,C1orf86,LAMTOR4, FASTK,FIS1,JOSD2,LMAN2,MPG,NDUFS7,INAFM1, RAB24,RABAC1,SIL1,SRA1,THAP3,TMED9,ZNHIT1 | ARFRP1,ASPSCR1,B4GALT7,BAD,TSR3,COPE,CRELD2, DPP7,MVB12A,FKBP8,GIPC1,GNB2,JMJD8,MBD3, MPG,MRPL28,MRPL55,RBM42,RPS19BP1,SSNA1,TRADD |
ALKBH4,B4GALT7,BCL7C,TSR3,C1orf35,C7orf50,CCDC12, DDX41,FASTK,GSTK1,HARS,HIGD2A,MBLAC1,MRPL55, MXD3,PRELID1,RAB24,RMND5B,SIL1,TMED9,WBSCR16 | AHCY,APEX1,APRT,B4GALT7,BID,CECR5,DPM2, ECE2,EXOSC5,FBXW9,MAPKAPK3,MLST8,NME2,RPL13A, RPL18A,RPLP0,SLC35B2,SYNGR2,URM1,WDR74,ZDHHC16 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for B4GALT7 |
There's no related Drug. |
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Cross referenced IDs for B4GALT7 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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