Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CHST14
Basic gene info.Gene symbolCHST14
Gene namecarbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
SynonymsATCS|D4ST1|EDSMC1|HNK1ST
CytomapUCSC genome browser: 15q15.1
Genomic locationchr15 :40763159-40765357
Type of geneprotein-coding
RefGenesNM_130468.3,
Ensembl idENSG00000169105
Descriptioncarbohydrate sulfotransferase 14dermatan 4 sulfotransferase 1
Modification date20141207
dbXrefs MIM : 608429
HGNC : HGNC
HPRD : 16780
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CHST14
BioGPS: 113189
Gene Expression Atlas: ENSG00000169105
The Human Protein Atlas: ENSG00000169105
PathwayNCI Pathway Interaction Database: CHST14
KEGG: CHST14
REACTOME: CHST14
ConsensusPathDB
Pathway Commons: CHST14
MetabolismMetaCyc: CHST14
HUMANCyc: CHST14
RegulationEnsembl's Regulation: ENSG00000169105
miRBase: chr15 :40,763,159-40,765,357
TargetScan: NM_130468
cisRED: ENSG00000169105
ContextiHOP: CHST14
cancer metabolism search in PubMed: CHST14
UCL Cancer Institute: CHST14
Assigned class in ccmGDBC

Top
Phenotypic Information for CHST14(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CHST14
Familial Cancer Database: CHST14
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_CARBOHYDRATES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: CHST14
MedGen: CHST14 (Human Medical Genetics with Condition)
ClinVar: CHST14
PhenotypeMGI: CHST14 (International Mouse Phenotyping Consortium)
PhenomicDB: CHST14

Mutations for CHST14
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CHST14 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BQ447574POLD21813874415428644154406CHST14134568154076388440764316

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=13)
Stat. for Synonymous SNVs
(# total SNVs=5)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr15:40764480-40764480p.I356I6
chr15:40763996-40763996p.R195L2
chr15:40764201-40764201p.F263F2
chr15:40763593-40763593p.E61*1
chr15:40764152-40764152p.A247V1
chr15:40763707-40763707p.D99H1
chr15:40764159-40764159p.A249A1
chr15:40763862-40763862p.L150L1
chr15:40764199-40764199p.F263L1
chr15:40764050-40764050p.R213L1

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1 11  1    1 1  31 3
# mutation2 11  1    1 1  32 3
nonsynonymous SNV1  1  1    1 1  22 3
synonymous SNV1 1             1   
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr15:40764480p.I356I2
chr15:40763707p.D99H1
chr15:40764364p.L150L1
chr15:40763862p.L180I1
chr15:40764412p.P215L1
chr15:40763950p.E229D1
chr15:40764056p.R231G1
chr15:40764524p.R231Q1
chr15:40764099p.R243S1
chr15:40764103p.Y245C1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CHST14 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for CHST14

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

CERCAM,CHPF,CHST14,COL18A1,COL1A1,COPZ2,CYGB,
EFEMP2,LEPRE1,MFRP,MRC2,MXRA8,OLFML2B,PPAPDC3,
SCARF2,SLC39A13,SPARC,SRP14,TGFB1,TGFB1I1,TNFSF12
B3GALT6,BCL7C,C2orf81,FAM212A,CCDC102A,CHST14,DOK4,
FLOT2,GHDC,IFI27L2,LRFN3,MOSPD3,NAALADL1,PLSCR3,
PPIB,PRKAR1B,RAB34,SNAPC2,STMN3,TMEM115,WDR54

AKT3,CCDC8,CERCAM,CHST14,CMTM3,COL6A2,EFEMP2,
EFS,GLT8D2,GNAI2,HHIPL1,LEPRE1,LOXL1,MEIS3,
MXRA8,NCKAP5L,NTNG2,OAZ2,RAB34,THY1,TPST1
VSTM4,CCDC102A,CCDC8,CHST14,CRTC3,FAM65A,FRMD4A,
GPR124,LEPREL2,LRP3,MAP3K3,MXRA8,NCKAP5L,PCDHGB7,
PIP4K2B,PNMAL2,RPS6KA2,SIX5,SMO,USP27X,VIM
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for CHST14


There's no related Drug.
Top
Cross referenced IDs for CHST14
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas