|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for CHST14 |
Top |
Phenotypic Information for CHST14(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: CHST14 |
Familial Cancer Database: CHST14 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
REACTOME_METABOLISM_OF_CARBOHYDRATES |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: CHST14 |
MedGen: CHST14 (Human Medical Genetics with Condition) | |
ClinVar: CHST14 | |
Phenotype | MGI: CHST14 (International Mouse Phenotyping Consortium) |
PhenomicDB: CHST14 |
Mutations for CHST14 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CHST14 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BQ447574 | POLD2 | 18 | 138 | 7 | 44154286 | 44154406 | CHST14 | 134 | 568 | 15 | 40763884 | 40764316 |
![]() |
Top |
![]() |
There's no copy number variation information in COSMIC data for this gene. |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=13) | (# total SNVs=5) |
![]() | ![]() |
(# total SNVs=0) | (# total SNVs=0) |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr15:40764480-40764480 | p.I356I | 6 |
chr15:40763996-40763996 | p.R195L | 2 |
chr15:40764201-40764201 | p.F263F | 2 |
chr15:40764412-40764412 | p.E334K | 1 |
chr15:40764103-40764103 | p.R231G | 1 |
chr15:40764475-40764475 | p.Y355H | 1 |
chr15:40764104-40764104 | p.R231Q | 1 |
chr15:40764146-40764146 | p.Y245C | 1 |
chr15:40764524-40764524 | p.K371R | 1 |
chr15:40763593-40763593 | p.E61* | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   | 1 | 1 |   |   | 1 |   |   |   |   | 1 |   | 1 |   |   | 3 | 1 |   | 3 |
# mutation | 2 |   | 1 | 1 |   |   | 1 |   |   |   |   | 1 |   | 1 |   |   | 3 | 2 |   | 3 |
nonsynonymous SNV | 1 |   |   | 1 |   |   | 1 |   |   |   |   | 1 |   | 1 |   |   | 2 | 2 |   | 3 |
synonymous SNV | 1 |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr15:40764480 | p.I356I | 2 |
chr15:40764146 | p.H318Y | 1 |
chr15:40764159 | p.E334K | 1 |
chr15:40764199 | p.K371R | 1 |
chr15:40763707 | p.D99H | 1 |
chr15:40764364 | p.L150L | 1 |
chr15:40763862 | p.L180I | 1 |
chr15:40764412 | p.P215L | 1 |
chr15:40763950 | p.E229D | 1 |
chr15:40764056 | p.R231G | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for CHST14 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |
CERCAM,CHPF,CHST14,COL18A1,COL1A1,COPZ2,CYGB, EFEMP2,LEPRE1,MFRP,MRC2,MXRA8,OLFML2B,PPAPDC3, SCARF2,SLC39A13,SPARC,SRP14,TGFB1,TGFB1I1,TNFSF12 | B3GALT6,BCL7C,C2orf81,FAM212A,CCDC102A,CHST14,DOK4, FLOT2,GHDC,IFI27L2,LRFN3,MOSPD3,NAALADL1,PLSCR3, PPIB,PRKAR1B,RAB34,SNAPC2,STMN3,TMEM115,WDR54 |
![]() | |
AKT3,CCDC8,CERCAM,CHST14,CMTM3,COL6A2,EFEMP2, EFS,GLT8D2,GNAI2,HHIPL1,LEPRE1,LOXL1,MEIS3, MXRA8,NCKAP5L,NTNG2,OAZ2,RAB34,THY1,TPST1 | VSTM4,CCDC102A,CCDC8,CHST14,CRTC3,FAM65A,FRMD4A, GPR124,LEPREL2,LRP3,MAP3K3,MXRA8,NCKAP5L,PCDHGB7, PIP4K2B,PNMAL2,RPS6KA2,SIX5,SMO,USP27X,VIM |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for CHST14 |
There's no related Drug. |
Top |
Cross referenced IDs for CHST14 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |