Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ADCY8
Basic gene info.Gene symbolADCY8
Gene nameadenylate cyclase 8 (brain)
SynonymsAC8|ADCY3|HBAC1
CytomapUCSC genome browser: 8q24
Genomic locationchr8 :131792546-132052835
Type of geneprotein-coding
RefGenesNM_001115.2,
Ensembl idENSG00000155897
DescriptionATP pyrophosphate-lyase 8adenylate cyclase type 8adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclase
Modification date20141222
dbXrefs MIM : 103070
HGNC : HGNC
Ensembl : ENSG00000155897
HPRD : 00051
Vega : OTTHUMG00000164756
ProteinUniProt: P40145
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADCY8
BioGPS: 114
Gene Expression Atlas: ENSG00000155897
The Human Protein Atlas: ENSG00000155897
PathwayNCI Pathway Interaction Database: ADCY8
KEGG: ADCY8
REACTOME: ADCY8
ConsensusPathDB
Pathway Commons: ADCY8
MetabolismMetaCyc: ADCY8
HUMANCyc: ADCY8
RegulationEnsembl's Regulation: ENSG00000155897
miRBase: chr8 :131,792,546-132,052,835
TargetScan: NM_001115
cisRED: ENSG00000155897
ContextiHOP: ADCY8
cancer metabolism search in PubMed: ADCY8
UCL Cancer Institute: ADCY8
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ADCY8 in cancer cell metabolism1. Liu Y, Chen SH, Li YM (2012) [Differential expression profiles of genes and miRNAs in alcoholic hepatitis]. Zhonghua Gan Zang Bing Za Zhi 20: 883-887. doi: 10.3760/cma.j.issn.1007-3418.2012.12.002. go to article

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Phenotypic Information for ADCY8(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ADCY8
Familial Cancer Database: ADCY8
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

check002.gifOthers
OMIM 103070; gene.
Orphanet
DiseaseKEGG Disease: ADCY8
MedGen: ADCY8 (Human Medical Genetics with Condition)
ClinVar: ADCY8
PhenotypeMGI: ADCY8 (International Mouse Phenotyping Consortium)
PhenomicDB: ADCY8

Mutations for ADCY8
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
breastADCY8chr8131975433131975433chr182026945320269453
ovaryADCY8chr8131897415131897435ADCY8chr8131857945131857965
ovaryADCY8chr8131908526131908546ADCY8chr8131916076131916096
ovaryADCY8chr8131997335131997355ADCY8chr8131975330131975350
ovaryADCY8chr8132000898132000918chr122825367728253697
ovaryADCY8chr8132033952132033972SNTB1chr8121735369121735389
ovaryADCY8chr8132037608132037628ADCY8chr8132042576132042596
ovaryADCY8chr8132046649132046669chr112677697226776992
pancreasADCY8chr8131953488131953508chr8130504278130504298
pancreasADCY8chr8131987992131988012ADCY8chr8131988353131988373
prostateADCY8chr8131964303131964303chr119835072998350729
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADCY8 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BQ345242ADCY8874788131890511131890902DNAJC14470632125621617256216430

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample62 2  7 4 4   1 1
GAIN (# sample)61 2  7 4 4   1 1
LOSS (# sample)11               
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=220)
Stat. for Synonymous SNVs
(# total SNVs=81)
Stat. for Deletions
(# total SNVs=3)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr8:131792904-131792904p.G1163E6
chr8:131826458-131826458p.R924C6
chr8:131916177-131916177p.T584T5
chr8:131848567-131848567p.Y877Y4
chr8:131880139-131880139p.I721I3
chr8:132052131-132052131p.R150Q3
chr8:131861945-131861945p.R772Q3
chr8:131916126-131916126p.I601I3
chr8:131921973-131921973p.E541K3
chr8:131792811-131792811p.A1194V3

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample6121342 14182 39202136530221
# mutation6121432 15192 47242137932227
nonsynonymous SNV68 302 12191 31182124521122
synonymous SNV 4113  3  1 166  1351115
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr8:131916126p.I601I4
chr8:132002665p.G547G3
chr8:131880139p.I582I3
chr8:131916177p.R362S3
chr8:131916288p.G1163E3
chr8:131792904p.R924C3
chr8:131916183p.T584T3
chr8:131826458p.I721I3
chr8:132052131p.D189D2
chr8:132052171p.S514L2

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ADCY8 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ADCY8

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADCY8,CHST1,CTTNBP2,DDX25,DKK4,EIF4E1B,FCRLB,
FZD10,HTR1E,INSM1,KIAA0087,LRP2,MLN,OR8S1,
OTX2,P2RX6P,PDZK1P1,SCUBE1,SLC35D3,SNAR-E,TUBA3E
ADCY8,C1orf68,C2,CCL13,CCR1,CD163,CD33,
DNM1,ECM1,EMP3,GAP43,GPNMB,KIRREL3,MARCO,
NXF3,SLC7A7,SPOCK1,SSC5D,TMEM106A,VCAN,VSIG4

AADAC,ADCY8,BAALC,CCR4,CLC,CSN2,FAM138D,
GABRR3,IL36B,LOC116437,LOC283856,LOC728392,LRRC7,OR4D1,
OR6B1,PNLIPRP3,RXRG,SPATA22,TFPI2,VWA5B1,VWC2L
ADCY8,ETNPPL,AHNAK,CDY2B,CSRP3,FAM131B,FAM19A4,
LOC151658,LRRFIP1,MYOCD,OPN5,OR2F1,PIP5K1C,POU4F2,
PTCHD1,PZP,RIMS3,RXFP2,SNX19,TMEM189,ZYG11B
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ADCY8
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryChEMBL CHEMBL2097167; -.
Organism-specific databasesPharmGKB PA29; -.
Organism-specific databasesCTD 114; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB01033adenylate cyclase 8 (brain)approvedMercaptopurine
DB00563adenylate cyclase 8 (brain)approvedMethotrexate
DB00938adenylate cyclase 8 (brain)approvedSalmeterol


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Cross referenced IDs for ADCY8
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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