Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AK7
Basic gene info.Gene symbolAK7
Gene nameadenylate kinase 7
SynonymsAK 7
CytomapUCSC genome browser: 14q32.2
Genomic locationchr14 :96858447-96955112
Type of geneprotein-coding
RefGenesNM_152327.3,
Ensembl idENSG00000140057
DescriptionATP-AMP transphosphorylase 7putative adenylate kinase 7
Modification date20141207
dbXrefs MIM : 615364
HGNC : HGNC
Ensembl : ENSG00000140057
HPRD : 10640
Vega : OTTHUMG00000171421
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AK7
BioGPS: 122481
Gene Expression Atlas: ENSG00000140057
The Human Protein Atlas: ENSG00000140057
PathwayNCI Pathway Interaction Database: AK7
KEGG: AK7
REACTOME: AK7
ConsensusPathDB
Pathway Commons: AK7
MetabolismMetaCyc: AK7
HUMANCyc: AK7
RegulationEnsembl's Regulation: ENSG00000140057
miRBase: chr14 :96,858,447-96,955,112
TargetScan: NM_152327
cisRED: ENSG00000140057
ContextiHOP: AK7
cancer metabolism search in PubMed: AK7
UCL Cancer Institute: AK7
Assigned class in ccmGDBC

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Phenotypic Information for AK7(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AK7
Familial Cancer Database: AK7
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: AK7
MedGen: AK7 (Human Medical Genetics with Condition)
ClinVar: AK7
PhenotypeMGI: AK7 (International Mouse Phenotyping Consortium)
PhenomicDB: AK7

Mutations for AK7
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryAK7chr149688273496882754SLC24A4chr149286241692862436
pancreasAK7chr149686871596868735chr149621390396213923
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AK7 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CN278364KDELR11132194889464448894775AK7126205149694490396944982
BU944613PAPOLA1170149696876996968938AK7170906149690417296937890

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=67)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr14:96864440-96864440p.S45L3
chr14:96953373-96953373p.E705K3
chr14:96924468-96924468p.E426K3
chr14:96924440-96924440p.N416N2
chr14:96944917-96944917p.L557L2
chr14:96953302-96953302p.R681K2
chr14:96875258-96875258p.R160C2
chr14:96909082-96909082p.E236K2
chr14:96922741-96922741p.E386*2
chr14:96937849-96937849p.M464I2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample41286 3  2 721 1182 10
# mutation412115 3  2 921 1252 10
nonsynonymous SNV11274 2  2 721 1191 9
synonymous SNV3  41 1    2    61 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr14:96875238p.E637K2
chr14:96924468p.D400Y2
chr14:96949491p.E705K2
chr14:96875256p.S153L2
chr14:96875258p.E426K2
chr14:96922783p.A159V2
chr14:96953373p.R160C2
chr14:96909069p.P166L1
chr14:96944839p.E336E1
chr14:96917817p.M464I1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AK7 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AK7

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AK7,AKAP14,APOBEC4,ARMC3,CFAP126,C5orf49,ADGB,
C6orf165,C7orf57,CAPSL,FAM183A,FOXJ1,ROPN1L,RSPH4A,
SNTN,TEKT1,TTC25,WDR38,WDR49,WDR63,ZBBX
AK7,CFAP43,SPATA6L,SPICE1,DNAH7,GALNT3,GDAP1,
HHAT,HOOK1,IFT81,IQCH,IRF6,KIAA1407,MYO6,
OCLN,PIH1D2,PLS1,PRRG4,RASEF,TTC8,WDR78

AGR2,AK7,BMP2,GSKIP,MCU,DLST,DMC1,
FAM102B,FUT8,GALNT12,GNPNAT1,GSTZ1,LIMA1,MED11,
POLD3,RSPH1,SPTLC2,TC2N,TMED10,TMEM30B,TNFRSF11A
AK7,AMMECR1,AURKA,CASC5,CENPI,COQ2,DIAPH3,
E2F7,FOXM1,GALK2,GINS4,GMDS,HELLS,IFITM1,
LARS2,LIPG,OLFM4,POC1A,RAD54L,TK1,VSNL1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AK7


There's no related Drug.
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Cross referenced IDs for AK7
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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