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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for AK7 |
Basic gene info. | Gene symbol | AK7 |
Gene name | adenylate kinase 7 | |
Synonyms | AK 7 | |
Cytomap | UCSC genome browser: 14q32.2 | |
Genomic location | chr14 :96858447-96955112 | |
Type of gene | protein-coding | |
RefGenes | NM_152327.3, | |
Ensembl id | ENSG00000140057 | |
Description | ATP-AMP transphosphorylase 7putative adenylate kinase 7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 615364 | |
HGNC : HGNC | ||
Ensembl : ENSG00000140057 | ||
HPRD : 10640 | ||
Vega : OTTHUMG00000171421 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AK7 | |
BioGPS: 122481 | ||
Gene Expression Atlas: ENSG00000140057 | ||
The Human Protein Atlas: ENSG00000140057 | ||
Pathway | NCI Pathway Interaction Database: AK7 | |
KEGG: AK7 | ||
REACTOME: AK7 | ||
ConsensusPathDB | ||
Pathway Commons: AK7 | ||
Metabolism | MetaCyc: AK7 | |
HUMANCyc: AK7 | ||
Regulation | Ensembl's Regulation: ENSG00000140057 | |
miRBase: chr14 :96,858,447-96,955,112 | ||
TargetScan: NM_152327 | ||
cisRED: ENSG00000140057 | ||
Context | iHOP: AK7 | |
cancer metabolism search in PubMed: AK7 | ||
UCL Cancer Institute: AK7 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for AK7(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: AK7 |
Familial Cancer Database: AK7 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: AK7 |
MedGen: AK7 (Human Medical Genetics with Condition) | |
ClinVar: AK7 | |
Phenotype | MGI: AK7 (International Mouse Phenotyping Consortium) |
PhenomicDB: AK7 |
Mutations for AK7 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | AK7 | chr14 | 96882734 | 96882754 | SLC24A4 | chr14 | 92862416 | 92862436 |
pancreas | AK7 | chr14 | 96868715 | 96868735 | chr14 | 96213903 | 96213923 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AK7 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CN278364 | KDELR1 | 1 | 132 | 19 | 48894644 | 48894775 | AK7 | 126 | 205 | 14 | 96944903 | 96944982 | |
BU944613 | PAPOLA | 1 | 170 | 14 | 96968769 | 96968938 | AK7 | 170 | 906 | 14 | 96904172 | 96937890 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=67) | (# total SNVs=17) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:96953373-96953373 | p.E705K | 3 |
chr14:96924468-96924468 | p.E426K | 3 |
chr14:96864440-96864440 | p.S45L | 3 |
chr14:96944917-96944917 | p.L557L | 2 |
chr14:96924440-96924440 | p.N416N | 2 |
chr14:96953302-96953302 | p.R681K | 2 |
chr14:96875258-96875258 | p.R160C | 2 |
chr14:96909082-96909082 | p.E236K | 2 |
chr14:96922741-96922741 | p.E386* | 2 |
chr14:96937849-96937849 | p.M464I | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 4 | 1 | 2 | 8 | 6 |   | 3 |   |   | 2 |   | 7 | 2 | 1 |   | 1 | 18 | 2 |   | 10 |
# mutation | 4 | 1 | 2 | 11 | 5 |   | 3 |   |   | 2 |   | 9 | 2 | 1 |   | 1 | 25 | 2 |   | 10 |
nonsynonymous SNV | 1 | 1 | 2 | 7 | 4 |   | 2 |   |   | 2 |   | 7 | 2 | 1 |   | 1 | 19 | 1 |   | 9 |
synonymous SNV | 3 |   |   | 4 | 1 |   | 1 |   |   |   |   | 2 |   |   |   |   | 6 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:96875238 | p.A159V | 2 |
chr14:96924468 | p.R160C | 2 |
chr14:96949491 | p.E637K | 2 |
chr14:96875256 | p.D400Y | 2 |
chr14:96875258 | p.E705K | 2 |
chr14:96922783 | p.S153L | 2 |
chr14:96953373 | p.E426K | 2 |
chr14:96924441 | p.I598M | 1 |
chr14:96953381 | p.A331A | 1 |
chr14:96909112 | p.E432D | 1 |
Other DBs for Point Mutations |
Copy Number for AK7 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for AK7 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
AK7,AKAP14,APOBEC4,ARMC3,CFAP126,C5orf49,ADGB, C6orf165,C7orf57,CAPSL,FAM183A,FOXJ1,ROPN1L,RSPH4A, SNTN,TEKT1,TTC25,WDR38,WDR49,WDR63,ZBBX | AK7,CFAP43,SPATA6L,SPICE1,DNAH7,GALNT3,GDAP1, HHAT,HOOK1,IFT81,IQCH,IRF6,KIAA1407,MYO6, OCLN,PIH1D2,PLS1,PRRG4,RASEF,TTC8,WDR78 |
AGR2,AK7,BMP2,GSKIP,MCU,DLST,DMC1, FAM102B,FUT8,GALNT12,GNPNAT1,GSTZ1,LIMA1,MED11, POLD3,RSPH1,SPTLC2,TC2N,TMED10,TMEM30B,TNFRSF11A | AK7,AMMECR1,AURKA,CASC5,CENPI,COQ2,DIAPH3, E2F7,FOXM1,GALK2,GINS4,GMDS,HELLS,IFITM1, LARS2,LIPG,OLFM4,POC1A,RAD54L,TK1,VSNL1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for AK7 |
There's no related Drug. |
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Cross referenced IDs for AK7 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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