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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ADH1A |
Basic gene info. | Gene symbol | ADH1A |
Gene name | alcohol dehydrogenase 1A (class I), alpha polypeptide | |
Synonyms | ADH1 | |
Cytomap | UCSC genome browser: 4q23 | |
Genomic location | chr4 :100197522-100212185 | |
Type of gene | protein-coding | |
RefGenes | NM_000667.3, | |
Ensembl id | ENSG00000187758 | |
Description | ADH, alpha subunitalcohol dehydrogenase 1 (class I), alpha polypeptidealcohol dehydrogenase 1Aalcohol dehydrogenase subunit alphaaldehyde reductase | |
Modification date | 20141207 | |
dbXrefs | MIM : 103700 | |
HGNC : HGNC | ||
Ensembl : ENSG00000187758 | ||
HPRD : 00063 | ||
Vega : OTTHUMG00000131026 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADH1A | |
BioGPS: 124 | ||
Gene Expression Atlas: ENSG00000187758 | ||
The Human Protein Atlas: ENSG00000187758 | ||
Pathway | NCI Pathway Interaction Database: ADH1A | |
KEGG: ADH1A | ||
REACTOME: ADH1A | ||
ConsensusPathDB | ||
Pathway Commons: ADH1A | ||
Metabolism | MetaCyc: ADH1A | |
HUMANCyc: ADH1A | ||
Regulation | Ensembl's Regulation: ENSG00000187758 | |
miRBase: chr4 :100,197,522-100,212,185 | ||
TargetScan: NM_000667 | ||
cisRED: ENSG00000187758 | ||
Context | iHOP: ADH1A | |
cancer metabolism search in PubMed: ADH1A | ||
UCL Cancer Institute: ADH1A | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ADH1A(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ADH1A |
Familial Cancer Database: ADH1A |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_GLYCOLYSIS_GLUCONEOGENESIS KEGG_FATTY_ACID_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ADH1A |
MedGen: ADH1A (Human Medical Genetics with Condition) | |
ClinVar: ADH1A | |
Phenotype | MGI: ADH1A (International Mouse Phenotyping Consortium) |
PhenomicDB: ADH1A |
Mutations for ADH1A |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADH1A related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=31) | (# total SNVs=18) |
(# total SNVs=0) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:100205629-100205629 | p.S165L | 3 |
chr4:100208729-100208729 | p.R38C | 3 |
chr4:100208120-100208120 | p.T49I | 3 |
chr4:100205753-100205753 | p.L124M | 2 |
chr4:100208142-100208142 | p.V42M | 2 |
chr4:100200661-100200661 | p.S342L | 2 |
chr4:100205628-100205628 | p.S165S | 2 |
chr4:100201412-100201412 | p.E285Q | 2 |
chr4:100197801-100197801 | p.R370C | 2 |
chr4:100203505-100203505 | p.M276V | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 6 | 2 |   | 1 |   | 5 |   |   | 3 | 2 | 1 |   |   | 15 | 6 |   | 5 |
# mutation | 1 | 1 |   | 6 | 2 |   | 1 |   | 4 |   |   | 7 | 2 | 1 |   |   | 15 | 6 |   | 6 |
nonsynonymous SNV | 1 | 1 |   | 5 | 2 |   | 1 |   | 2 |   |   | 6 | 1 |   |   |   | 12 | 4 |   | 2 |
synonymous SNV |   |   |   | 1 |   |   |   |   | 2 |   |   | 1 | 1 | 1 |   |   | 3 | 2 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:100208729 | p.R38C | 3 |
chr4:100205628 | p.S165S | 2 |
chr4:100205629 | p.S165L | 2 |
chr4:100205662 | p.D154V | 2 |
chr4:100203503 | p.L308M | 1 |
chr4:100208074 | p.T179T | 1 |
chr4:100203763 | p.V77A | 1 |
chr4:100200605 | p.I292I | 1 |
chr4:100205754 | p.P166T | 1 |
chr4:100203562 | p.V74M | 1 |
Other DBs for Point Mutations |
Copy Number for ADH1A in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ADH1A |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACSM5,ACVR1C,ADH1A,ADH1B,ADIPOQ,AOC3,AQP7, AQP7P1,AQP7P3,AQPEP,CHRDL1,CIDEC,GPD1,HEPACAM, KCNIP2,KLB,LIPE,LOC283392,PLIN1,SLC19A3,TMEM132C | ABHD15,ACACB,ACSS3,ACVR1C,ADH1A,ADH1B,ANKRD53, CALCRL,CIDEA,CNTFR,DNAH9,ECHDC3,GHR,HADH, HRSP12,LOC100190938,MAOA,MOCS1,SLC19A3,TM7SF2,TMEM132C | ||||
ABCA8,ABCA9,ACSM5,ADH1A,ADH1B,ADIPOQ,CD300LG, CD36,CIDEA,FABP4,GPX3,LGALS12,LOC339524,PDE1B, PLAC9,PLIN1,PLIN4,SCN4A,SEMA3G,TUSC5,WISP2 | ADH1A,ADH1B,CARD6,CCL13,CD36,CREG1,CTSK, FCGR2B,FCGR2C,FOLR2,GBGT1,MRC1,MS4A4A,MYL3, RNASE1,RNF130,RRAGD,SERPINF1,TMEM100,TNNT1,VSIG4 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ADH1A |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | alcohol dehydrogenase 1A (class I), alpha polypeptide | approved; nutraceutical | NADH | ||
DB00898 | alcohol dehydrogenase 1A (class I), alpha polypeptide | approved | Ethanol | ||
DB01213 | alcohol dehydrogenase 1A (class I), alpha polypeptide | approved | Fomepizole | ||
DB01907 | alcohol dehydrogenase 1A (class I), alpha polypeptide | experimental | Nicotinamide-Adenine-Dinucleotide | ||
DB02721 | alcohol dehydrogenase 1A (class I), alpha polypeptide | experimental | 4-Iodopyrazole | ||
DB04065 | alcohol dehydrogenase 1A (class I), alpha polypeptide | experimental | N-Cyclopentyl-N-Cyclobutylformamide |
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Cross referenced IDs for ADH1A |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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