Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CANT1
Basic gene info.Gene symbolCANT1
Gene namecalcium activated nucleotidase 1
SynonymsDBQD|SCAN-1|SCAN1|SHAPY
CytomapUCSC genome browser: 17q25.3
Genomic locationchr17 :76987797-77005899
Type of geneprotein-coding
RefGenesNM_001159772.1,
NM_001159773.1,NM_138793.3,
Ensembl idENSG00000171302
DescriptionCa2+-dependent endoplasmic reticulum nucleoside diphosphataseapyrase homologmicromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossificationputative MAPK-activating protein PM09putative NF-kappa-B-activating prote
Modification date20141207
dbXrefs MIM : 613165
HGNC : HGNC
Ensembl : ENSG00000171302
HPRD : 13003
Vega : OTTHUMG00000177570
ProteinUniProt: Q8WVQ1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CANT1
BioGPS: 124583
Gene Expression Atlas: ENSG00000171302
The Human Protein Atlas: ENSG00000171302
PathwayNCI Pathway Interaction Database: CANT1
KEGG: CANT1
REACTOME: CANT1
ConsensusPathDB
Pathway Commons: CANT1
MetabolismMetaCyc: CANT1
HUMANCyc: CANT1
RegulationEnsembl's Regulation: ENSG00000171302
miRBase: chr17 :76,987,797-77,005,899
TargetScan: NM_001159772
cisRED: ENSG00000171302
ContextiHOP: CANT1
cancer metabolism search in PubMed: CANT1
UCL Cancer Institute: CANT1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of CANT1 in cancer cell metabolism1. Gerhardt J, Steinbrech C, Buchi O, Behnke S, Bohnert A, et al. (2011) The androgen-regulated Calcium-Activated Nucleotidase 1 (CANT1) is commonly overexpressed in prostate cancer and is tumor-biologically relevant in vitro. Am J Pathol 178: 1847-1860. doi: 10.1016/j.ajpath.2010.12.046. pmid: 3078458 go to article

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Phenotypic Information for CANT1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CANT1
Familial Cancer Database: CANT1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM
KEGG_PYRIMIDINE_METABOLISM

check002.gifOthers
OMIM 251450; phenotype.
613165; gene.
Orphanet 1425; Desbuquois syndrome.
DiseaseKEGG Disease: CANT1
MedGen: CANT1 (Human Medical Genetics with Condition)
ClinVar: CANT1
PhenotypeMGI: CANT1 (International Mouse Phenotyping Consortium)
PhenomicDB: CANT1

Mutations for CANT1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CANT1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
EU693078CANT11128177700145477001581ETV4127389174161063741613849
BE816214CANT11211177698878776988997CANT1209277177698901276989080

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=26)
Stat. for Synonymous SNVs
(# total SNVs=19)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr17:76993313-76993313p.K131R2
chr17:76993507-76993507p.G67fs*632
chr17:76989644-76989644p.I398M2
chr17:76991114-76991114p.G274A2
chr17:76993522-76993522p.S61S2
chr17:76993169-76993169p.S179F2
chr17:76993539-76993539p.L56F2
chr17:76991166-76991166p.V257M2
chr17:76993423-76993423p.S94S2
chr17:76989937-76989937p.R301C1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample12161 2    551  104 5
# mutation12161 2    551  94 7
nonsynonymous SNV 1 31      331  74 1
synonymous SNV1113  2    22   2  6
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr17:76993539p.S61S,CANT12
chr17:76993522p.L56F,CANT12
chr17:76991254p.S303T,CANT11
chr17:76993303p.L136M,CANT11
chr17:76989810p.M15T,CANT11
chr17:76993529p.R301C,CANT11
chr17:76993104p.L134L,CANT11
chr17:76989644p.I398M,CANT11
chr17:76993313p.A271V,CANT11
chr17:76989811p.K131R,CANT11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CANT1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for CANT1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

BAIAP2,HID1,C17orf80,CANT1,COG1,CSNK1D,DNAJA4,
DYNLL2,KCTD2,KIAA0195,LLGL2,MIF4GD,MTMR4,PBX1,
RNF43,RPTOR,SLC26A11,SLC27A4,SLC9A3R1,SYNGR2,TBCD
AP1M2,ARHGAP39,CANT1,CDH1,CRB3,CREB3L4,DLG3,
ERBB3,FAM83H,FKBP4,GOLM1,ILDR1,KIAA1324,CAMSAP3,
MAPK13,MARVELD2,RAB11FIP4,SEZ6L2,SHROOM2,SPDEF,TJP3

BACE2,HID1,TMEM246,CANT1,CDC42EP4,CREB3L1,FAM57A,
FOXA3,FUT8,FFAR4,LRP10,MLPH,P4HB,PTGER2,
SERPINB1,SGPP2,SH2D4A,ST6GALNAC1,VPS37B,VWA3B,ZBTB7C
ACVRL1,APH1A,CANT1,CDC42EP5,CDX1,DHX32,GALNT12,
GIPC1,GUSB,ILDR1,IMPA2,ITM2C,LIMK2,LLGL2,
LSR,MAGIX,MARCH3,OVOL2,RHBDL2,TMPRSS4,TOR2A
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for CANT1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
Organism-specific databasesPharmGKB PA134984439; -.
Organism-specific databasesCTD 124583; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB03486calcium activated nucleotidase 1experimentalPhosphomethylphosphonic Acid Guanosyl Ester
DB03754calcium activated nucleotidase 1experimentalTris(Hydroxymethyl)Aminomethane


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Cross referenced IDs for CANT1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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