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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ADH1C |
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Phenotypic Information for ADH1C(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ADH1C |
Familial Cancer Database: ADH1C |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_GLYCOLYSIS_GLUCONEOGENESIS KEGG_FATTY_ACID_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ADH1C |
MedGen: ADH1C (Human Medical Genetics with Condition) | |
ClinVar: ADH1C | |
Phenotype | MGI: ADH1C (International Mouse Phenotyping Consortium) |
PhenomicDB: ADH1C |
Mutations for ADH1C |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADH1C related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=0) | (# total SNVs=0) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
# mutation |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
nonsynonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
Other DBs for Point Mutations |
Copy Number for ADH1C in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ADH1C |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACADL,ADH1C,AKR1B15,ALOX15B,CHRNA2,CLDN8,CTNNA2, ISX,KLHL31,LOC91948,LST-3TM12,NANOG,OR2W5,PGC, RLN3,RNASE12,SLCO1B1,SPINK8,SPINT3,SRD5A1,UGT2B28 | ADH1C,ADH5,ANTXR2,AQP7,AVPI1,PQLC2L,CYB5A, EBF1,EIF4EBP2,GABARAPL1,GPD1,GTF2E2,GYPE,LARP6, NRN1,PEX19,PLA2G16,PPP2R5A,PRDX6,RNASE4,EMC3 | ||||
ADH1C,AMPD1,B3GALT1,ADTRP,CA1,CA2,CDKN2B-AS1, DRD5,ENTPD5,TMEM236,NXPE1,GBA3,GPR15,PBLD, PLCE1,SCNN1B,SLC25A34,TMIGD1,UGT1A10,UGT2B15,WSCD1 | ADH1C,ALDH3A1,B4GALNT2,BDH1,APMAP,SAYSD1,EHHADH, FAM45A,GJB1,KCNV1,MEST,AP5M1,NDUFA10,PCCA, PCTP,PEX11A,RPP25,SH2D4A,STARD7,SUCLG2,TEKT5 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ADH1C |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | alcohol dehydrogenase 1C (class I), gamma polypeptide | approved; nutraceutical | NADH | ||
DB00898 | alcohol dehydrogenase 1C (class I), gamma polypeptide | approved | Ethanol | ||
DB01213 | alcohol dehydrogenase 1C (class I), gamma polypeptide | approved | Fomepizole | ||
DB01711 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 2,3,4,5,6-Pentafluorobenzyl Alcohol | ||
DB01907 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Nicotinamide-Adenine-Dinucleotide | ||
DB02131 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | N-1-Methylheptylformamide | ||
DB02249 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 2-Ethoxyethanol | ||
DB02659 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Cholic Acid | ||
DB02721 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 4-Iodopyrazole | ||
DB02757 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Pyrazole | ||
DB02822 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Para-Bromobenzyl Alcohol | ||
DB02871 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 3-Butylthiolane 1-Oxide | ||
DB03020 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide | ||
DB03061 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | (R)-N-(1-Methyl-Hexyl)-Formamide | ||
DB03226 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Trifluoroethanol | ||
DB03559 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Cyclohexylformamide | ||
DB04071 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | Cpad | ||
DB04113 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | N-Formylpiperidine | ||
DB04312 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 2,3-Difluorobenzyl Alcohol | ||
DB04448 | alcohol dehydrogenase 1C (class I), gamma polypeptide | experimental | 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene |
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Cross referenced IDs for ADH1C |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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