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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for METTL6 |
Basic gene info. | Gene symbol | METTL6 |
Gene name | methyltransferase like 6 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 3p25.1 | |
Genomic location | chr3 :15451376-15469042 | |
Type of gene | protein-coding | |
RefGenes | NM_001301790.1, NM_001301791.1,NM_001301792.1,NM_152396.3, | |
Ensembl id | ENSG00000206562 | |
Description | methyltransferase-like protein 6 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000206562 | ||
HPRD : 14494 | ||
Vega : OTTHUMG00000156431 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_METTL6 | |
BioGPS: 131965 | ||
Gene Expression Atlas: ENSG00000206562 | ||
The Human Protein Atlas: ENSG00000206562 | ||
Pathway | NCI Pathway Interaction Database: METTL6 | |
KEGG: METTL6 | ||
REACTOME: METTL6 | ||
ConsensusPathDB | ||
Pathway Commons: METTL6 | ||
Metabolism | MetaCyc: METTL6 | |
HUMANCyc: METTL6 | ||
Regulation | Ensembl's Regulation: ENSG00000206562 | |
miRBase: chr3 :15,451,376-15,469,042 | ||
TargetScan: NM_001301790 | ||
cisRED: ENSG00000206562 | ||
Context | iHOP: METTL6 | |
cancer metabolism search in PubMed: METTL6 | ||
UCL Cancer Institute: METTL6 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for METTL6(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: METTL6 |
Familial Cancer Database: METTL6 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_HISTIDINE_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_SELENOAMINO_ACID_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: METTL6 |
MedGen: METTL6 (Human Medical Genetics with Condition) | |
ClinVar: METTL6 | |
Phenotype | MGI: METTL6 (International Mouse Phenotyping Consortium) |
PhenomicDB: METTL6 |
Mutations for METTL6 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | METTL6 | chr3 | 15467429 | 15467449 | chr3 | 16195910 | 16195930 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows METTL6 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=21) | (# total SNVs=5) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr3:15467851-15467851 | p.F56L | 3 |
chr3:15452786-15452786 | p.L278L | 1 |
chr3:15455639-15455639 | p.R188C | 1 |
chr3:15466516-15466516 | p.P102P | 1 |
chr3:15452819-15452819 | p.L267I | 1 |
chr3:15455670-15455670 | p.? | 1 |
chr3:15466599-15466599 | p.? | 1 |
chr3:15452842-15452842 | p.R259K | 1 |
chr3:15457283-15457283 | p.Y176C | 1 |
chr3:15467794-15467794 | p.E75D | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 7 |   |   | 2 |   | 1 |   |   | 1 | 1 | 1 |   |   | 4 | 1 |   | 5 |
# mutation |   |   |   | 8 |   |   | 2 |   | 1 |   |   | 1 | 1 | 1 |   |   | 4 | 1 |   | 5 |
nonsynonymous SNV |   |   |   | 6 |   |   | 2 |   | 1 |   |   | 1 | 1 | 1 |   |   | 3 | 1 |   | 4 |
synonymous SNV |   |   |   | 2 |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr3:15467851 | p.F56L | 3 |
chr3:15457355 | p.D152G | 2 |
chr3:15457358 | p.I104I | 1 |
chr3:15467880 | p.P102P | 1 |
chr3:15452786 | p.L278L | 1 |
chr3:15457374 | p.V90I | 1 |
chr3:15467907 | p.L255L | 1 |
chr3:15452853 | p.E75D | 1 |
chr3:15457386 | p.L255M | 1 |
chr3:15467989 | p.L230I | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for METTL6 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ANKRD28,TAMM41,CAPN7,CHCHD4,COLQ,DPH3,EAF1, FANCD2,HACL1,LSM3,METTL6,MKRN2,OXNAD1,RAB5A, RAD18,RAF1,SETD5,THUMPD3,TRNT1,TSEN2,ZFYVE20 | AASDH,ANKRD32,CDC23,CEP76,CEP78,COG6,HS2ST1, IMPACT,LRRC37BP1,LRRC57,METTL6,NOL8,PDS5A,PWWP2A, RAD17,SEPSECS,SMARCAD1,SUZ12,THAP6,TRMT5,ZNF429 |
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COA5,TIMMDC1,C3orf17,COMMD2,CRBN,DPM1,DYNC1LI1, EIF1B,GTF2E1,HACL1,LSM3,METTL6,PNO1,SETMAR, SS18L2,THOC7,THUMPD3,TRNT1,UBA3,UBE2E1,WDR53 | ALKBH2,BBS4,BRF2,ARL14EP,TMEM263,KXD1,BRK1, DYRK4,FAM109B,FBXO16,IFT46,MAD2L2,METTL6,MPV17, MRPL40,MRPS6,MSL3,RPL39L,SNX10,TMEM9,TRMT112 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for METTL6 |
There's no related Drug. |
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Cross referenced IDs for METTL6 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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