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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MUC17 |
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Phenotypic Information for MUC17(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: MUC17 |
Familial Cancer Database: MUC17 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in GBM 6, |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 6 http://www.sciencedirect.com/science/article/pii/S0092867413012087, 7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS |
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OMIM | 608424; gene. |
Orphanet | |
Disease | KEGG Disease: MUC17 |
MedGen: MUC17 (Human Medical Genetics with Condition) | |
ClinVar: MUC17 | |
Phenotype | MGI: MUC17 (International Mouse Phenotyping Consortium) |
PhenomicDB: MUC17 |
Mutations for MUC17 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | MUC17 | chr7 | 100699692 | 100699712 | PIK3CG | chr7 | 106544439 | 106544459 |
pancreas | MUC17 | chr7 | 100665367 | 100665567 | MUC17 | chr7 | 100672510 | 100672710 |
pancreas | MUC17 | chr7 | 100671956 | 100671976 | MUC17 | chr7 | 100673162 | 100673182 |
pancreas | MUC17 | chr7 | 100682570 | 100682590 | DYNC1I1 | chr7 | 95699401 | 95699421 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC17 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=689) | (# total SNVs=213) |
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(# total SNVs=4) | (# total SNVs=1) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr7:100677279-100677279 | p.S861T | 8 |
chr7:100686777-100686777 | p.T4027K | 4 |
chr7:100680060-100680060 | p.S1788L | 4 |
chr7:100680242-100680242 | p.P1849A | 4 |
chr7:100678887-100678887 | p.P1397L | 4 |
chr7:100683647-100683647 | p.E2984K | 4 |
chr7:100685938-100685938 | p.M3747I | 3 |
chr7:100677409-100677409 | p.S904S | 3 |
chr7:100682348-100682348 | p.E2551Q | 3 |
chr7:100675090-100675090 | p.S131S | 3 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 22 | 27 | 7 | 60 | 29 |   | 40 |   | 28 | 4 | 1 | 101 | 39 | 31 | 2 | 8 | 100 | 47 | 9 | 42 |
# mutation | 24 | 27 | 8 | 71 | 28 |   | 52 |   | 26 | 4 | 1 | 155 | 53 | 31 | 2 | 8 | 193 | 67 | 9 | 97 |
nonsynonymous SNV | 19 | 22 | 6 | 54 | 21 |   | 33 |   | 22 | 1 | 1 | 119 | 35 | 18 | 2 | 6 | 148 | 51 | 6 | 78 |
synonymous SNV | 5 | 5 | 2 | 17 | 7 |   | 19 |   | 4 | 3 |   | 36 | 18 | 13 |   | 2 | 45 | 16 | 3 | 19 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr7:100680242 | p.P1849S | 4 |
chr7:100676844 | p.S1788L | 3 |
chr7:100675090 | p.P2880P | 3 |
chr7:100685938 | p.S716N | 3 |
chr7:100680525 | p.S131S | 3 |
chr7:100680060 | p.I1943T | 3 |
chr7:100683337 | p.M3747I | 3 |
chr7:100686647 | p.P1397L | 2 |
chr7:100679927 | p.E645Q | 2 |
chr7:100686997 | p.S1083P | 2 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MUC17 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ACTR3BP2,GK2,KRTAP19-2,KRTAP25-1,KRTAP6-1,MUC17,OR10H3, OR4C16,OR4L1,OR51A4,OR51G1,OR52A5,OR52J3,OR5D18, OR5I1,OR5L1,OR5L2,OR6C75,OR8H3,POM121L12,REG1P | CA1,CCL14-CCL15,CES1,COL8A1,DGKK,FAM92A1P2,LOC100287718, LOC643923,MGC27382,MUC17,NLRP3,NNAT,OR10K1,OR2B11, OR3A4P,OR5AS1,POU6F2,PRAMEF6,PROK1,SLC6A18,TAAR1 |
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ABCG2,ALPI,BTNL8,C11orf86,LINC00520,C1orf94,CAPN11, CIDEC,CTSE,FAM25BP,GCNT3,MALL,MUC17,MYPN, PTPRH,SDCBP2,TMEM92,UGT1A1,UGT1A4,UGT1A5,VSIG1 | ABCC2,ACE,ALDOB,CYP2D6,CYP3A4,DPP4,FABP6, FGF19,GSTA1,GSTA2,HAPLN4,MGAM,MME,MUC17, NTS,RBP2,SLC10A2,SLC34A3,SLC5A12,SULT1E1,UGT1A4 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for MUC17 |
There's no related Drug. |
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Cross referenced IDs for MUC17 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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