Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MUC17
Basic gene info.Gene symbolMUC17
Gene namemucin 17, cell surface associated
SynonymsMUC3
CytomapUCSC genome browser: 7q22.1
Genomic locationchr7 :100663363-100702140
Type of geneprotein-coding
RefGenesNM_001040105.1,
NM_001004430.1,
Ensembl idENSG00000169876
DescriptionMUC-17MUC-3membrane mucin MUC17mucin-17secreted mucin MUC17small intestinal mucin MUC3small intestinal mucin-3
Modification date20141207
dbXrefs MIM : 608424
HGNC : HGNC
Ensembl : ENSG00000169876
HPRD : 16335
Vega : OTTHUMG00000157030
ProteinUniProt: Q685J3
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MUC17
BioGPS: 140453
Gene Expression Atlas: ENSG00000169876
The Human Protein Atlas: ENSG00000169876
PathwayNCI Pathway Interaction Database: MUC17
KEGG: MUC17
REACTOME: MUC17
ConsensusPathDB
Pathway Commons: MUC17
MetabolismMetaCyc: MUC17
HUMANCyc: MUC17
RegulationEnsembl's Regulation: ENSG00000169876
miRBase: chr7 :100,663,363-100,702,140
TargetScan: NM_001040105
cisRED: ENSG00000169876
ContextiHOP: MUC17
cancer metabolism search in PubMed: MUC17
UCL Cancer Institute: MUC17
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for MUC17(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MUC17
Familial Cancer Database: MUC17
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in GBM 6,

Therapeutic Vulnerabilities in Cancer7

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
6 http://www.sciencedirect.com/science/article/pii/S0092867413012087,
7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM 608424; gene.
Orphanet
DiseaseKEGG Disease: MUC17
MedGen: MUC17 (Human Medical Genetics with Condition)
ClinVar: MUC17
PhenotypeMGI: MUC17 (International Mouse Phenotyping Consortium)
PhenomicDB: MUC17

Mutations for MUC17
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryMUC17chr7100699692100699712PIK3CGchr7106544439106544459
pancreasMUC17chr7100665367100665567MUC17chr7100672510100672710
pancreasMUC17chr7100671956100671976MUC17chr7100673162100673182
pancreasMUC17chr7100682570100682590DYNC1I1chr79569940195699421
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC17 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample     1           
GAIN (# sample)     1           
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=11

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=689)
Stat. for Synonymous SNVs
(# total SNVs=213)
Stat. for Deletions
(# total SNVs=4)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:100677279-100677279p.S861T8
chr7:100683647-100683647p.E2984K4
chr7:100680060-100680060p.S1788L4
chr7:100686777-100686777p.T4027K4
chr7:100680242-100680242p.P1849A4
chr7:100678887-100678887p.P1397L4
chr7:100683941-100683941p.E3082K3
chr7:100674409-100674409p.V31L3
chr7:100679543-100679543p.A1616T3
chr7:100686501-100686501p.P3935L3

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample222776029 40 284110139312810047942
# mutation242787128 52 264115553312819367997
nonsynonymous SNV192265421 33 221111935182614851678
synonymous SNV552177 19 43 361813 24516319
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:100680242p.P1849S4
chr7:100676844p.I1943T3
chr7:100680525p.P2880P3
chr7:100680060p.S716N3
chr7:100683337p.S131S3
chr7:100675090p.M3747I3
chr7:100685938p.S1788L3
chr7:100679879p.E2041K2
chr7:100675651p.T1170M2
chr7:100684511p.T2633S2

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MUC17 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MUC17

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACTR3BP2,GK2,KRTAP19-2,KRTAP25-1,KRTAP6-1,MUC17,OR10H3,
OR4C16,OR4L1,OR51A4,OR51G1,OR52A5,OR52J3,OR5D18,
OR5I1,OR5L1,OR5L2,OR6C75,OR8H3,POM121L12,REG1P
CA1,CCL14-CCL15,CES1,COL8A1,DGKK,FAM92A1P2,LOC100287718,
LOC643923,MGC27382,MUC17,NLRP3,NNAT,OR10K1,OR2B11,
OR3A4P,OR5AS1,POU6F2,PRAMEF6,PROK1,SLC6A18,TAAR1

ABCG2,ALPI,BTNL8,C11orf86,LINC00520,C1orf94,CAPN11,
CIDEC,CTSE,FAM25BP,GCNT3,MALL,MUC17,MYPN,
PTPRH,SDCBP2,TMEM92,UGT1A1,UGT1A4,UGT1A5,VSIG1
ABCC2,ACE,ALDOB,CYP2D6,CYP3A4,DPP4,FABP6,
FGF19,GSTA1,GSTA2,HAPLN4,MGAM,MME,MUC17,
NTS,RBP2,SLC10A2,SLC34A3,SLC5A12,SULT1E1,UGT1A4
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MUC17


There's no related Drug.
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Cross referenced IDs for MUC17
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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