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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for NANP |
Basic gene info. | Gene symbol | NANP |
Gene name | N-acetylneuraminic acid phosphatase | |
Synonyms | C20orf147|HDHD4|dJ694B14.3 | |
Cytomap | UCSC genome browser: 20p11.1 | |
Genomic location | chr20 :25593572-25604648 | |
Type of gene | protein-coding | |
RefGenes | NM_152667.2, | |
Ensembl id | ENSG00000170191 | |
Description | N-acylneuraminate-9-phosphataseNeu5Ac-9-Pasehaloacid dehalogenase-like hydrolase domain containing 4haloacid dehalogenase-like hydrolase domain-containing protein 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610763 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170191 | ||
HPRD : 17097 | ||
Vega : OTTHUMG00000032132 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NANP | |
BioGPS: 140838 | ||
Gene Expression Atlas: ENSG00000170191 | ||
The Human Protein Atlas: ENSG00000170191 | ||
Pathway | NCI Pathway Interaction Database: NANP | |
KEGG: NANP | ||
REACTOME: NANP | ||
ConsensusPathDB | ||
Pathway Commons: NANP | ||
Metabolism | MetaCyc: NANP | |
HUMANCyc: NANP | ||
Regulation | Ensembl's Regulation: ENSG00000170191 | |
miRBase: chr20 :25,593,572-25,604,648 | ||
TargetScan: NM_152667 | ||
cisRED: ENSG00000170191 | ||
Context | iHOP: NANP | |
cancer metabolism search in PubMed: NANP | ||
UCL Cancer Institute: NANP | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for NANP(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: NANP |
Familial Cancer Database: NANP |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: NANP |
MedGen: NANP (Human Medical Genetics with Condition) | |
ClinVar: NANP | |
Phenotype | MGI: NANP (International Mouse Phenotyping Consortium) |
PhenomicDB: NANP |
Mutations for NANP |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
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- For Intra-chromosomal Variations |
There's no intra-chromosomal structural variation. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
central_nervous_system | NANP | chr20 | 25595621 | 25595621 | chr17 | 15807796 | 15807796 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NANP related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=10) | (# total SNVs=3) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr20:25597039-25597039 | p.R90T | 2 |
chr20:25596776-25596776 | p.G178R | 2 |
chr20:25597030-25597030 | p.A93G | 1 |
chr20:25596622-25596622 | p.S229F | 1 |
chr20:25596634-25596634 | p.Y225C | 1 |
chr20:25597043-25597043 | p.N89H | 1 |
chr20:25596644-25596644 | p.V222F | 1 |
chr20:25597049-25597049 | p.A87P | 1 |
chr20:25596672-25596672 | p.N212N | 1 |
chr20:25597053-25597053 | p.G85G | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   |   | 1 |   | 2 |   |   |   |   | 3 | 1 |   |   |   | 1 | 2 |   | 2 |
# mutation |   | 1 |   |   | 1 |   | 2 |   |   |   |   | 3 | 1 |   |   |   | 1 | 2 |   | 2 |
nonsynonymous SNV |   | 1 |   |   | 1 |   | 1 |   |   |   |   | 2 |   |   |   |   |   | 1 |   | 1 |
synonymous SNV |   |   |   |   |   |   | 1 |   |   |   |   | 1 | 1 |   |   |   | 1 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr20:25597200 | p.P223P | 1 |
chr20:25596639 | p.N212N | 1 |
chr20:25604502 | p.T206T | 1 |
chr20:25596672 | p.G178R | 1 |
chr20:25604531 | p.D134H | 1 |
chr20:25596690 | p.T131T | 1 |
chr20:25596776 | p.A111S | 1 |
chr20:25596908 | p.A93G | 1 |
chr20:25596915 | p.A87P | 1 |
chr20:25596977 | p.A79G | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for NANP |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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MGME1,CENPI,CHEK1,DBF4,DLGAP5,ERCC6L,ESF1, GINS1,GMPS,KIF18A,MAPRE1,MCM8,NANP,PCNA, PNPT1,POLR3F,RBBP9,STIL,SUV39H2,TPX2,TRMT6 | ATP6AP2,C3orf38,CAPZA1,GOLT1B,GRPEL2,KCTD6,NANP, NDFIP1,PDCD10,PLEKHA3,RAB22A,RBM7,SREK1IP1,SSR1, CNEP1R1,TMX1,TRAM1,TXNDC9,VMA21,YIPF5,ZNF684 |
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ABHD12,APMAP,AAR2,CRNKL1,CSTF1,CTNNBL1,DSN1, ENTPD6,GINS1,ITCH,MAPRE1,NAA20,NANP,NXT1, PIGU,POLR3F,RPRD1B,NELFCD,XRN2,YTHDF1,ZNF337 | FAM204A,AAED1,COPS3,COPS8,CTNNAL1,DIMT1,DNAJC8, GLO1,LSM10,MOCS2,MORF4L2,MTMR6,NANP,BBIP1, NMD3,PEX3,PRKRA,RNF115,RWDD1,UBA2,UTP11L |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for NANP |
There's no related Drug. |
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Cross referenced IDs for NANP |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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