Cancer Cell Metabolism Gene Database

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MAPK14
Basic gene info.Gene symbolMAPK14
Gene namemitogen-activated protein kinase 14
SynonymsCSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA
CytomapUCSC genome browser: 6p21.3-p21.2
Genomic locationchr6 :35995453-36079013
Type of geneprotein-coding
RefGenesNM_001315.2,
NM_139012.2,NM_139013.2,NM_139014.2,
Ensembl idENSG00000112062
DescriptionCSAID-binding proteinCsaids binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteincytokine suppressive anti-inflammatory drug-binding proteinmitogen-activ
Modification date20141222
dbXrefs MIM : 600289
HGNC : HGNC
Ensembl : ENSG00000112062
HPRD : 02619
Vega : OTTHUMG00000159806
ProteinUniProt: Q16539
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPK14
BioGPS: 1432
Gene Expression Atlas: ENSG00000112062
The Human Protein Atlas: ENSG00000112062
PathwayNCI Pathway Interaction Database: MAPK14
KEGG: MAPK14
REACTOME: MAPK14
ConsensusPathDB
Pathway Commons: MAPK14
MetabolismMetaCyc: MAPK14
HUMANCyc: MAPK14
RegulationEnsembl's Regulation: ENSG00000112062
miRBase: chr6 :35,995,453-36,079,013
TargetScan: NM_001315
cisRED: ENSG00000112062
ContextiHOP: MAPK14
cancer metabolism search in PubMed: MAPK14
UCL Cancer Institute: MAPK14
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of MAPK14 in cancer cell metabolism1. Grossi V, Peserico A, Tezil T, Simone C (2014) p38alpha MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol 20: 9744-9758. doi: 10.3748/wjg.v20.i29.9744. pmid: 4123363. go to article

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Phenotypic Information for MAPK14(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MAPK14
Familial Cancer Database: MAPK14
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM 600289; gene.
600289; gene.
Orphanet
DiseaseKEGG Disease: MAPK14
MedGen: MAPK14 (Human Medical Genetics with Condition)
ClinVar: MAPK14
PhenotypeMGI: MAPK14 (International Mouse Phenotyping Consortium)
PhenomicDB: MAPK14

Mutations for MAPK14
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
breastMAPK14chr63606046836060468PDE2Achr117237076172370761
breastMAPK14chr63606751536067915MAPK14chr63607266936073069
ovaryMAPK14chr63603161036031630MAPK14chr63603176936031789
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAPK14 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AI652202TPI118721269799386979992MAPK146920563607669736076833
CA429031MAPK141844263607811236078536MEMO143866023225475532264853
BF183021MAPK14167463607526536075323MAPK147257663607531936076574
BM826654MAPK14112463603871236038835POP510742212121017498121017812
L35253LEMD311287126556358865563864MAPK14277153963599591736076386

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample          1      
GAIN (# sample)          1      
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=26)
Stat. for Synonymous SNVs
(# total SNVs=11)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr6:36020511-36020511p.A51V3
chr6:36070418-36070418p.N278I3
chr6:36075327-36075327p.D313N3
chr6:36044336-36044336p.C211C2
chr6:36041850-36041850p.V158M2
chr6:36020504-36020521p.R49_K54delRVAVKK1
chr6:36070387-36070387p.M268L1
chr6:36027100-36027100p.R94K1
chr6:36041852-36041852p.V158V1
chr6:36070398-36070398p.A271A1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample13 10  2 1  3131 51 5
# mutation13 9  2 1  3131 51 5
nonsynonymous SNV 2 7  1 1  212  31 3
synonymous SNV11 2  1    1 11 2  2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr6:36070418p.N278S,MAPK143
chr6:36041850p.V158M,MAPK142
chr6:36020559p.R94K,MAPK141
chr6:36043686p.L104L,MAPK141
chr6:36070426p.P279P,MAPK141
chr6:36020563p.G110A,MAPK141
chr6:36043701p.A281S,MAPK141
chr6:36075254p.L135I,MAPK141
chr6:36020576p.C262F,MAPK141
chr6:36043714p.L135L,MAPK141

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MAPK14 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MAPK14

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.
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check002.gifProtein Expression Plot (RPPA)
*RPPA protein expression data were extracted from TCPA (The Cancer Proteome Atlas). Normalized data based on replicated based normalization (RBN) was used to draw following figures.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACTR2,ANAPC1,ARL5B,C6orf106,CDC5L,KCTD20,LOC284441,
MAPK14,MOB1A,NUP153,OSBPL11,RIF1,ROCK2,RRAGC,
SCYL2,SLC30A6,SRPK1,STRN,TRAM2,UHRF1BP1,ZNF318
ANO6,ANTXR2,ATG12,CALCOCO2,CD302,CELF2,COL4A3BP,
EIF4EBP2,JAK1,MAPK14,MDFIC,NR3C1,PDE8A,PROSC,
PVRL3,PXK,RRAGC,SNX5,STX7,TACC1,VAMP3

AVL9,FAM217B,CDC5L,CDK8,EPB41L5,ITCH,KCTD20,
GPALPP1,KLHL23,MAPK14,BLOC1S5,PRKAR2A,ROCK2,RPL7L1,
SMEK2,SRPK1,STK38,STT3B,USP6NL,ZNF322,ZNF451
ASB8,TRMT1L,CCDC132,FGFR2,GAB1,GABPA,HBP1,
MAPK14,MFAP1,MORC3,OSBPL1A,OXR1,PPAP2A,PPP1CB,
PRSS23,RAB5B,RNF146,TAB2,TXNIP,ZNF19,ZNF563
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MAPK14
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB Q16539; -.
ChemistryChEMBL CHEMBL2094115; -.
ChemistryGuidetoPHARMACOLOGY 1499; -.
ChemistryBindingDB Q16539; -.
ChemistryChEMBL CHEMBL2094115; -.
ChemistryGuidetoPHARMACOLOGY 1499; -.
Organism-specific databasesPharmGKB PA30621; -.
Organism-specific databasesPharmGKB PA30621; -.
Organism-specific databasesCTD 1432; -.
Organism-specific databasesCTD 1432; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB01761mitogen-activated protein kinase 14experimental4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine
DB01807mitogen-activated protein kinase 14experimentalN-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N'-(4-Chlorophenyl)Urea
DB01948mitogen-activated protein kinase 14experimental1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One
DB01953mitogen-activated protein kinase 14experimentalInhibitor of P38 Kinase
DB01988mitogen-activated protein kinase 14experimental6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine
DB02195mitogen-activated protein kinase 14experimental3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine
DB02277mitogen-activated protein kinase 14experimental1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea
DB02352mitogen-activated protein kinase 14experimental3-(Benzyloxy)Pyridin-2-Amine
DB02873mitogen-activated protein kinase 14experimental1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
DB02984mitogen-activated protein kinase 14experimental4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
DB03044mitogen-activated protein kinase 14experimental1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea
DB03110mitogen-activated protein kinase 14experimental2-Chlorophenol
DB03980mitogen-activated protein kinase 14experimental4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole
DB04338mitogen-activated protein kinase 14experimentalSB220025
DB04632mitogen-activated protein kinase 14experimental4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
DB04797mitogen-activated protein kinase 14experimentalTriazolopyridine
DB06882mitogen-activated protein kinase 14experimental1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
DB06940mitogen-activated protein kinase 14experimentalN-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
DB06991mitogen-activated protein kinase 14experimentalN-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide
DB07138mitogen-activated protein kinase 14experimental5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
DB07307mitogen-activated protein kinase 14experimentalN-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
DB07459mitogen-activated protein kinase 14experimental4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE
DB07607mitogen-activated protein kinase 14experimental4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
DB07811mitogen-activated protein kinase 14experimentalN-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide
DB07829mitogen-activated protein kinase 14experimental4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE
DB07832mitogen-activated protein kinase 14experimental4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde
DB07833mitogen-activated protein kinase 14experimentalN-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
DB07834mitogen-activated protein kinase 14experimentalN-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide
DB07835mitogen-activated protein kinase 14experimentalN~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide
DB07941mitogen-activated protein kinase 14experimental3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide
DB07942mitogen-activated protein kinase 14experimental2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
DB07943mitogen-activated protein kinase 14experimental2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol
DB08064mitogen-activated protein kinase 14experimentalN-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA
DB08068mitogen-activated protein kinase 14experimentalN-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO-
DB08091mitogen-activated protein kinase 14experimental3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE
DB08092mitogen-activated protein kinase 14experimental3-FLUORO-N-1H-INDOL-5-YL-5-MORPHOLIN-4-YLBENZAMIDE
DB08093mitogen-activated protein kinase 14experimental3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
DB08095mitogen-activated protein kinase 14experimental3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA
DB08096mitogen-activated protein kinase 14experimental8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM
DB08097mitogen-activated protein kinase 14experimental2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE
DB08242mitogen-activated protein kinase 14experimentalN,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
DB08349mitogen-activated protein kinase 14experimentalN-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide
DB08351mitogen-activated protein kinase 14experimentalN-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide
DB08352mitogen-activated protein kinase 14experimental6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
DB08395mitogen-activated protein kinase 14experimental2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE
DB08423mitogen-activated protein kinase 14experimental[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
DB08424mitogen-activated protein kinase 14experimental[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
DB08521mitogen-activated protein kinase 14experimental4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
DB08522mitogen-activated protein kinase 14experimental4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE
DB08730mitogen-activated protein kinase 14experimental3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
DB00724mitogen-activated protein kinase 14approved; investigationalImiquimod
DB00122mitogen-activated protein kinase 14approved; nutraceuticalCholine
DB00864mitogen-activated protein kinase 14approved; investigationalTacrolimus
DB01234mitogen-activated protein kinase 14approved; investigationalDexamethasone
DB00608mitogen-activated protein kinase 14approvedChloroquine
DB00877mitogen-activated protein kinase 14approved; investigationalSirolimus
DB00171mitogen-activated protein kinase 14approved; nutraceuticalAdenosine triphosphate
DB00398mitogen-activated protein kinase 14approved; investigationalSorafenib
DB00125mitogen-activated protein kinase 14approved; nutraceuticalL-Arginine
DB00435mitogen-activated protein kinase 14approvedNitric Oxide


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Cross referenced IDs for MAPK14
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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