Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ALG10B
Basic gene info.Gene symbolALG10B
Gene nameALG10B, alpha-1,2-glucosyltransferase
SynonymsALG10|KCR1
CytomapUCSC genome browser: 12q12
Genomic locationchr12 :38710556-38723528
Type of geneprotein-coding
RefGenesNM_001013620.3,
Ensembl idENSG00000175548
Descriptionalpha-1,2-glucosyltransferase ALG10-Aalpha-2-glucosyltransferase ALG10-Basparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog Basparagine-linked gly
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000175548
HPRD : 11923
Vega : OTTHUMG00000169298
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALG10B
BioGPS: 144245
Gene Expression Atlas: ENSG00000175548
The Human Protein Atlas: ENSG00000175548
PathwayNCI Pathway Interaction Database: ALG10B
KEGG: ALG10B
REACTOME: ALG10B
ConsensusPathDB
Pathway Commons: ALG10B
MetabolismMetaCyc: ALG10B
HUMANCyc: ALG10B
RegulationEnsembl's Regulation: ENSG00000175548
miRBase: chr12 :38,710,556-38,723,528
TargetScan: NM_001013620
cisRED: ENSG00000175548
ContextiHOP: ALG10B
cancer metabolism search in PubMed: ALG10B
UCL Cancer Institute: ALG10B
Assigned class in ccmGDBC

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Phenotypic Information for ALG10B(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ALG10B
Familial Cancer Database: ALG10B
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ALG10B
MedGen: ALG10B (Human Medical Genetics with Condition)
ClinVar: ALG10B
PhenotypeMGI: ALG10B (International Mouse Phenotyping Consortium)
PhenomicDB: ALG10B

Mutations for ALG10B
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALG10B related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AI382716RPS4X1064X7149245371492507ALG10B62205123871618538716327

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=44)
Stat. for Synonymous SNVs
(# total SNVs=11)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=2)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr12:38714227-38714227p.E212Q2
chr12:38715000-38715000p.Q469Q2
chr12:38714340-38714340p.M249I2
chr12:38714267-38714267p.G225V2
chr12:38714532-38714532p.K313N2
chr12:38710735-38710735p.S14G2
chr12:38714424-38714424p.G277G2
chr12:38714050-38714050p.E153K1
chr12:38714429-38714429p.R279Q1
chr12:38714632-38714632p.L347L1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 4 131 1 31 925  7516
# mutation 4 131 2 31 1125  7516
nonsynonymous SNV 3 101 2 21 915  4415
synonymous SNV 1 3    1  21   31 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr12:38714532p.M249I2
chr12:38714340p.G277G2
chr12:38714424p.K313N2
chr12:38714267p.G225V2
chr12:38710735p.S14G2
chr12:38712204p.W58L1
chr12:38714512p.A193V1
chr12:38714203p.A376D1
chr12:38714922p.P60P1
chr12:38710828p.V194V1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ALG10B in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ALG10B

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ALG10B,CARF,ARID2,BBS10,FAM208A,C5orf24,CHD6,
CHM,CSNK1G3,DMXL1,GXYLT1,N4BP2,PIK3C2A,PREPL,
SEPSECS,SP1,STAG2,TRIM23,USP30,ZBTB26,ZKSCAN8
ALG10,ALG10B,ANGEL2,CCNT2,FNDC3A,G2E3,GOPC,
CEP44,KLHL28,MIB1,MTX3,NFAT5,PHC3,PHIP,
PPIP5K2,PTAR1,SENP7,SLC25A36,TRIM33,ZMYM1,ZNF148

ADNP,ALG10B,CARF,AS3MT,BBS10,FLJ10038,HDGFRP3,
ITCH,LOC728819,METTL6,MOCS3,PCMTD2,PGBD4,PPHLN1,
RLN2,SPAG16,SPIN3,TIGD7,TMEM55A,YAF2,ZNF563
ALG10B,C22orf15,DCAF16,FRS2,HKR1,KIAA0355,LOC100101266,
PAN3,PLEKHA5,RNMT,SHPRH,ZBTB44,ZNF112,ZNF12,
ZNF141,ZNF146,ZNF283,ZNF317,ZNF33A,ZNF417,ZNF738
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ALG10B


There's no related Drug.
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Cross referenced IDs for ALG10B
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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