Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AANAT
Basic gene info.Gene symbolAANAT
Gene namearalkylamine N-acetyltransferase
SynonymsDSPS|SNAT
CytomapUCSC genome browser: 17q25.1
Genomic locationchr17 :74463629-74466199
Type of geneprotein-coding
RefGenesNM_001088.2,
NM_001166579.1,NR_110548.1,
Ensembl idENSG00000129673
Descriptionarylalkylamine N-acetyltransferaseserotonin N-acetyltransferaseserotonin acetylase
Modification date20141207
dbXrefs MIM : 600950
HGNC : HGNC
Ensembl : ENSG00000129673
HPRD : 02974
Vega : OTTHUMG00000180179
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AANAT
BioGPS: 15
Gene Expression Atlas: ENSG00000129673
The Human Protein Atlas: ENSG00000129673
PathwayNCI Pathway Interaction Database: AANAT
KEGG: AANAT
REACTOME: AANAT
ConsensusPathDB
Pathway Commons: AANAT
MetabolismMetaCyc: AANAT
HUMANCyc: AANAT
RegulationEnsembl's Regulation: ENSG00000129673
miRBase: chr17 :74,463,629-74,466,199
TargetScan: NM_001088
cisRED: ENSG00000129673
ContextiHOP: AANAT
cancer metabolism search in PubMed: AANAT
UCL Cancer Institute: AANAT
Assigned class in ccmGDBC

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Phenotypic Information for AANAT(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AANAT
Familial Cancer Database: AANAT
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_TRYPTOPHAN_METABOLISM
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: AANAT
MedGen: AANAT (Human Medical Genetics with Condition)
ClinVar: AANAT
PhenotypeMGI: AANAT (International Mouse Phenotyping Consortium)
PhenomicDB: AANAT

Mutations for AANAT
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AANAT related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=11)
Stat. for Synonymous SNVs
(# total SNVs=3)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr17:74465822-74465822p.Q132*2
chr17:74464970-74464970p.A48T2
chr17:74464834-74464834p.S2S1
chr17:74464986-74464986p.R53H1
chr17:74466051-74466051p.*208L1
chr17:74464836-74464836p.T3M1
chr17:74465259-74465259p.F56L1
chr17:74464865-74464865p.A13T1
chr17:74465758-74465758p.T110T1
chr17:74464885-74464885p.G19G1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  12 1         4  2
# mutation1  12 1         4  2
nonsynonymous SNV1  11 1         1  2
synonymous SNV    1           3   
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr17:74464834p.A13T,AANAT1
chr17:74465918p.G19G,AANAT1
chr17:74464865p.A48T,AANAT1
chr17:74464885p.R53H,AANAT1
chr17:74464970p.F56L,AANAT1
chr17:74464986p.E87K,AANAT1
chr17:74465259p.G115G,AANAT1
chr17:74465350p.V126M,AANAT1
chr17:74465773p.R128R,AANAT1
chr17:74465804p.V153M,AANAT1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AANAT in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AANAT

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AANAT,BIRC8,SMCO3,C7orf43,CDK5R2,DAPK2,DET1,
DKK2,ERP27,FRG1,FRMPD2B,KCNK16,PLP1,PTCD1,
SERPINE1,AKAP17A,SLC12A9,TCEAL4,UBC,WDR59,ZNF789
AANAT,ATP11AUN,C6orf15,CGB2,DEFB125,FLJ45445,GH2,
HDGFL1,HELT,IGFALS,LOC100133161,MARVELD1,MYH16,ANKRD30BL,
NPTX1,OR10J5,PODNL1,PSG8,SLC6A19,TESC,TMEM163

AANAT,ACMSD,CABS1,CREG2,DGCR10,DGCR9,DKFZP434K028,
DNMT3L,EPHX3,FAM99A,GOLGA6A,LPIN2,MIR155HG,MT1B,
OR4C15,OTX1,PARP14,PRF1,RHBDF2,SFRP5,SLC10A2
AANAT,AMH,APBB3,ATG16L2,ATHL1,C17orf47,ENTHD2,
CCDC142,CHKB-CPT1B,CLDN9,CPT1B,ENGASE,PCED1A,KIAA1875,
LOC338799,LOC349114,PIDD1,PMS2P3,POLM,SELO,STRC
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AANAT
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00360aralkylamine N-acetyltransferaseapproved; investigationalTetrahydrobiopterin
DB00150aralkylamine N-acetyltransferaseapproved; nutraceuticalL-Tryptophan


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Cross referenced IDs for AANAT
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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