Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ADRA2A
Basic gene info.Gene symbolADRA2A
Gene nameadrenoceptor alpha 2A
SynonymsADRA2|ADRA2R|ADRAR|ALPHA2AAR|ZNF32
CytomapUCSC genome browser: 10q25.2
Genomic locationchr10 :112836789-112840662
Type of geneprotein-coding
RefGenesNM_000681.3,
Ensembl idENSG00000150594
Descriptionadrenergic, alpha-2A-, receptoralpha-2 adrenergic receptor subtype C10alpha-2-adrenergic receptor, platelet typealpha-2A adrenergic receptoralpha-2A adrenoceptoralpha-2A adrenoreceptoralpha-2AAR subtype C10
Modification date20141207
dbXrefs MIM : 104210
HGNC : HGNC
Ensembl : ENSG00000150594
HPRD : 00078
Vega : OTTHUMG00000019050
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADRA2A
BioGPS: 150
Gene Expression Atlas: ENSG00000150594
The Human Protein Atlas: ENSG00000150594
PathwayNCI Pathway Interaction Database: ADRA2A
KEGG: ADRA2A
REACTOME: ADRA2A
ConsensusPathDB
Pathway Commons: ADRA2A
MetabolismMetaCyc: ADRA2A
HUMANCyc: ADRA2A
RegulationEnsembl's Regulation: ENSG00000150594
miRBase: chr10 :112,836,789-112,840,662
TargetScan: NM_000681
cisRED: ENSG00000150594
ContextiHOP: ADRA2A
cancer metabolism search in PubMed: ADRA2A
UCL Cancer Institute: ADRA2A
Assigned class in ccmGDBC

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Phenotypic Information for ADRA2A(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ADRA2A
Familial Cancer Database: ADRA2A
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ADRA2A
MedGen: ADRA2A (Human Medical Genetics with Condition)
ClinVar: ADRA2A
PhenotypeMGI: ADRA2A (International Mouse Phenotyping Consortium)
PhenomicDB: ADRA2A

Mutations for ADRA2A
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADRA2A related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=34)		Stat. for Synonymous SNVs
(# total SNVs=15)
Stat. for Deletions
(# total SNVs=0)		Stat. for Insertions
(# total SNVs=2)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr10:112838344-112838344p.Q182L2
chr10:112838845-112838845p.P349L1
chr10:112839055-112839055p.S419N1
chr10:112838147-112838147p.F116L1
chr10:112838931-112838931p.V378L1
chr10:112838248-112838248p.I150T1
chr10:112838975-112838975p.F392L1
chr10:112838854-112838854p.E352G1
chr10:112839059-112839059p.S420S1
chr10:112838169-112838169p.L124M1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample2 25  1    6  1126 10
# mutation2 35  1    6  1136 10
nonsynonymous SNV   3       2  1124 8
synonymous SNV2 32  1    4    12 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr10:112838875p.A374V2
chr10:112838922p.I150T1
chr10:112838169p.V390L1
chr10:112838286p.E155E1
chr10:112838931p.V393L1
chr10:112838174p.V69I1
chr10:112838297p.R163H1
chr10:112837959p.Y409H1
chr10:112838979p.V73M1
chr10:112838175p.I165T1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ADRA2A in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ADRA2A

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADRA2A,WBP1L,DHX29,EBF3,GDF10,GHR,GLUD1,
HIGD1C,HSPA12B,HTR1B,IL6ST,KLHDC1,KLK12,KLK14,
KRTAP6-2,NRXN3,RAI2,RANBP3L,ZNF224,ZNF226,ZNF230		ADRA2A,ASAH1,BTD,FAM213A,C19orf12,C2CD2,DHDDS,
EPAS1,FZD4,GNS,HRASLS5,LOC158376,MGST1,MMD,
PALM2-AKAP2,PYGL,SAR1A,SEPT11,SORBS1,TK2,VKORC1L1

ACY3,ADH6,ADRA2A,B3GALT5,BCAR4,BTNL8,LINC00483,
CA9,CES2,CLTC,COX8C,DNM2,DOK4,KIAA1211,
LIMA1,LIPC,MUC17,OSTalpha,SLC41A2,SULT1C2,ABHD11-AS1		ACOX1,ADRA2A,AGFG2,APLP2,ARF3,RHOV___CHP1,CLIP2,
EHHADH,FUT3,HSD17B2,LOC25845,NDRG1,NETO2,OPN3,
RTN3,SFXN5,SLC16A1,SLC20A1,SLC9A3,STK38,WSCD1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ADRA2A
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00217adrenoceptor alpha 2AapprovedBethanidine
DB00246adrenoceptor alpha 2AapprovedZiprasidone
DB00248adrenoceptor alpha 2AapprovedCabergoline
DB00268adrenoceptor alpha 2Aapproved; investigationalRopinirole
DB00320adrenoceptor alpha 2AapprovedDihydroergotamine
DB00321adrenoceptor alpha 2AapprovedAmitriptyline
DB00334adrenoceptor alpha 2Aapproved; investigationalOlanzapine
DB00363adrenoceptor alpha 2AapprovedClozapine
DB00368adrenoceptor alpha 2AapprovedNorepinephrine
DB00370adrenoceptor alpha 2AapprovedMirtazapine
DB00397adrenoceptor alpha 2Aapproved; withdrawnPhenylpropanolamine
DB00413adrenoceptor alpha 2Aapproved; investigationalPramipexole
DB00449adrenoceptor alpha 2AapprovedDipivefrin
DB00484adrenoceptor alpha 2AapprovedBrimonidine
DB00543adrenoceptor alpha 2AapprovedAmoxapine
DB00575adrenoceptor alpha 2AapprovedClonidine
DB00589adrenoceptor alpha 2AapprovedLisuride
DB00629adrenoceptor alpha 2AapprovedGuanabenz
DB00633adrenoceptor alpha 2AapprovedDexmedetomidine
DB00656adrenoceptor alpha 2Aapproved; investigationalTrazodone
DB00668adrenoceptor alpha 2AapprovedEpinephrine
DB00692adrenoceptor alpha 2AapprovedPhentolamine
DB00696adrenoceptor alpha 2AapprovedErgotamine
DB00697adrenoceptor alpha 2AapprovedTizanidine
DB00714adrenoceptor alpha 2Aapproved; investigationalApomorphine
DB00734adrenoceptor alpha 2Aapproved; investigationalRisperidone
DB00751adrenoceptor alpha 2Aapproved; investigationalEpinastine
DB00797adrenoceptor alpha 2AapprovedTolazoline
DB00800adrenoceptor alpha 2AapprovedFenoldopam
DB00852adrenoceptor alpha 2AapprovedPseudoephedrine
DB00865adrenoceptor alpha 2Aillicit; approvedBenzphetamine
DB00925adrenoceptor alpha 2AapprovedPhenoxybenzamine
DB00935adrenoceptor alpha 2AapprovedOxymetazoline
DB00964adrenoceptor alpha 2AapprovedApraclonidine
DB00968adrenoceptor alpha 2AapprovedMethyldopa
DB01018adrenoceptor alpha 2Aapproved; investigationalGuanfacine
DB01049adrenoceptor alpha 2AapprovedErgoloid mesylate
DB01142adrenoceptor alpha 2AapprovedDoxepin
DB01149adrenoceptor alpha 2Aapproved; withdrawnNefazodone
DB01186adrenoceptor alpha 2Aapproved; withdrawnPergolide
DB01200adrenoceptor alpha 2Aapproved; investigationalBromocriptine
DB01224adrenoceptor alpha 2AapprovedQuetiapine
DB01238adrenoceptor alpha 2Aapproved; investigationalAripiprazole
DB01267adrenoceptor alpha 2AapprovedPaliperidone
DB01287adrenoceptor alpha 2AapprovedDihydroergotoxine
DB01392adrenoceptor alpha 2AapprovedYohimbine
DB01403adrenoceptor alpha 2AapprovedMethotrimeprazine
DB01472adrenoceptor alpha 2Aillicit; experimental4-Methoxyamphetamine
DB01577adrenoceptor alpha 2Aillicit; approvedMethamphetamine
DB01608adrenoceptor alpha 2AapprovedPropericiazine
DB01624adrenoceptor alpha 2AapprovedZuclopenthixol
DB04948adrenoceptor alpha 2Aapproved; investigationalLofexidine
DB06148adrenoceptor alpha 2AapprovedMianserin
DB06262adrenoceptor alpha 2Aapproved; investigationalDroxidopa
DB06694adrenoceptor alpha 2AapprovedXylometazoline
DB06711adrenoceptor alpha 2AapprovedNaphazoline
DB01105adrenoceptor alpha 2Aillicit; approved; withdrawn; investigationalSibutramine
DB00422adrenoceptor alpha 2Aapproved; investigationalMethylphenidate


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Cross referenced IDs for ADRA2A
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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