Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MBOAT1
Basic gene info.Gene symbolMBOAT1
Gene namemembrane bound O-acyltransferase domain containing 1
Synonyms1|LPEAT1|LPLAT|LPLAT 1|LPSAT|OACT1|dJ434O11.1
CytomapUCSC genome browser: 6p22.3
Genomic locationchr6 :20100934-20212670
Type of geneprotein-coding
RefGenesNM_001080480.2,
NR_073465.1,
Ensembl idENSG00000172197
Description1-acylglycerophosphoserine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 1O-acyltransferase domain-containing protein 1lyso-PS acyltransferaselysophosphatidylethanolamine acyltransferase 1lysophosphatidylserine acyltransferase
Modification date20141207
dbXrefs MIM : 611732
HGNC : HGNC
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MBOAT1
BioGPS: 154141
Gene Expression Atlas: ENSG00000172197
The Human Protein Atlas: ENSG00000172197
PathwayNCI Pathway Interaction Database: MBOAT1
KEGG: MBOAT1
REACTOME: MBOAT1
ConsensusPathDB
Pathway Commons: MBOAT1
MetabolismMetaCyc: MBOAT1
HUMANCyc: MBOAT1
RegulationEnsembl's Regulation: ENSG00000172197
miRBase: chr6 :20,100,934-20,212,670
TargetScan: NM_001080480
cisRED: ENSG00000172197
ContextiHOP: MBOAT1
cancer metabolism search in PubMed: MBOAT1
UCL Cancer Institute: MBOAT1
Assigned class in ccmGDBC

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Phenotypic Information for MBOAT1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MBOAT1
Familial Cancer Database: MBOAT1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCEROLIPID_METABOLISM
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM
REACTOME_PHOSPHOLIPID_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: MBOAT1
MedGen: MBOAT1 (Human Medical Genetics with Condition)
ClinVar: MBOAT1
PhenotypeMGI: MBOAT1 (International Mouse Phenotyping Consortium)
PhenomicDB: MBOAT1

Mutations for MBOAT1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryMBOAT1chr62011192820112128TNCchr9117857870117858070
ovaryMBOAT1chr62011194820112148TNCchr9117857868117858068
ovaryMBOAT1chr62016224620162266chr62891821228918232
pancreasMBOAT1chr62011197220112172TNCchr9117857825117858025
pancreasMBOAT1chr62011202620112226TNCchr9117857662117857862
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MBOAT1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AJ705329MBOAT1118662012493320125119RPL3718037454083255640834357

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample5  1  1         5
GAIN (# sample)5  1            5
LOSS (# sample)      1          
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=34)
Stat. for Synonymous SNVs
(# total SNVs=20)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr6:20113188-20113188p.L376L2
chr6:20128943-20128943p.R173*2
chr6:20152869-20152869p.I77I2
chr6:20124775-20124775p.T257T2
chr6:20118754-20118754p.A309T2
chr6:20126827-20126827p.G212V1
chr6:20109840-20109840p.I450I1
chr6:20113185-20113185p.S377S1
chr6:20151417-20151417p.R108*1
chr6:20124681-20124681p.M289V1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample13 91 3 2  4 1  17 9
# mutation13 81 3 2  4 1  17 11
nonsynonymous SNV 1 71 2    3 1   5 5
synonymous SNV12 1  1 2  1    12 6
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr6:20118754p.T257T2
chr6:20124704p.L376L2
chr6:20113188p.A309T2
chr6:20124775p.R281Q2
chr6:20152989p.T261T1
chr6:20109910p.A43S1
chr6:20118736p.P448P1
chr6:20144501p.T259T1
chr6:20152998p.V37V1
chr6:20109980p.W427L1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MBOAT1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MBOAT1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ATP6V1B1,C5orf42,CDK19,CTNND2,DRD1,ELOVL2,FAM8A1,
HOOK1,KDM1B,MAGI1,MBOAT1,NIPAL3,NUP153,OR4F15,
PTPN13,RALBP1,RB1CC1,SYNJ2,TAC3,UBR5,VEZF1
AAGAB,AGR3,C3orf52,CA12,CDH1,CDS1,FBXO16,
GOLM1,HHAT,MARVELD2,MBOAT1,PIP4K2C,PPAPDC1B,PRRG4,
RUNDC1,SEC14L2,TPD52,TTC39A,TTC8,XBP1,ZYG11A

TMEM246,CREB3L1,ERN2,GALNT12,GFI1,GRIN1,HMG20B,
KCNK1,KLF4,MBOAT1,MLPH,MRAP2,SERINC4,SGSM3,
SIDT1,SLC22A23,ST6GALNAC1,SYTL1,TSPAN13,VWA3B,ZBTB7C
ACSS2,AGFG2,ATP8B1,C5orf30,CCDC88C,CD24,HARS2,
MARVELD2,MBOAT1,MKRN1,NSF,PIGR,PRR5L,SDHA,
SH3BGRL2,SH3BP1,SH3KBP1,SLC4A4,TNK1,TRAF3IP2,ZNF217
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MBOAT1


There's no related Drug.
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Cross referenced IDs for MBOAT1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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