|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ADSL |
Basic gene info. | Gene symbol | ADSL |
Gene name | adenylosuccinate lyase | |
Synonyms | AMPS|ASASE|ASL | |
Cytomap | UCSC genome browser: 22q13.2 | |
Genomic location | chr22 :40742503-40762575 | |
Type of gene | protein-coding | |
RefGenes | NM_000026.2, NM_001123378.1, | |
Ensembl id | ENSG00000239900 | |
Description | adenylosuccinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 608222 | |
HGNC : HGNC | ||
Ensembl : ENSG00000239900 | ||
HPRD : 00049 | ||
Vega : OTTHUMG00000166425 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADSL | |
BioGPS: 158 | ||
Gene Expression Atlas: ENSG00000239900 | ||
The Human Protein Atlas: ENSG00000239900 | ||
Pathway | NCI Pathway Interaction Database: ADSL | |
KEGG: ADSL | ||
REACTOME: ADSL | ||
ConsensusPathDB | ||
Pathway Commons: ADSL | ||
Metabolism | MetaCyc: ADSL | |
HUMANCyc: ADSL | ||
Regulation | Ensembl's Regulation: ENSG00000239900 | |
miRBase: chr22 :40,742,503-40,762,575 | ||
TargetScan: NM_000026 | ||
cisRED: ENSG00000239900 | ||
Context | iHOP: ADSL | |
cancer metabolism search in PubMed: ADSL | ||
UCL Cancer Institute: ADSL | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for ADSL(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: ADSL |
Familial Cancer Database: ADSL |
* This gene is included in those cancer gene databases. |
. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
KEGG_PURINE_METABOLISM KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM REACTOME_METABOLISM_OF_NUCLEOTIDES REACTOME_PURINE_METABOLISM |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ADSL |
MedGen: ADSL (Human Medical Genetics with Condition) | |
ClinVar: ADSL | |
Phenotype | MGI: ADSL (International Mouse Phenotyping Consortium) |
PhenomicDB: ADSL |
Mutations for ADSL |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
- Statistics for Tissue and Mutation type | Top |
![]() |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
![]() |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
![]() |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ADSL | chr22 | 40751258 | 40751278 | chr22 | 41457740 | 41457760 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADSL related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   |   |   |   | 2 | 1 |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   | 2 | 1 |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=39) | (# total SNVs=12) |
![]() | ![]() |
(# total SNVs=0) | (# total SNVs=0) |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr22:40762493-40762493 | p.S474S | 5 |
chr22:40759035-40759035 | p.T354M | 3 |
chr22:40745999-40745999 | p.I106T | 2 |
chr22:40746000-40746000 | p.I106I | 2 |
chr22:40742702-40742702 | p.A47G | 2 |
chr22:40745877-40745877 | p.M65I | 1 |
chr22:40746034-40746034 | p.N118D | 1 |
chr22:40761043-40761043 | p.G451S | 1 |
chr22:40755310-40755310 | p.R234K | 1 |
chr22:40745897-40745897 | p.I72N | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 3 | 1 | 17 |   |   | 4 |   | 2 | 1 |   |   | 1 | 1 |   |   | 6 | 5 |   | 7 |
# mutation | 2 | 3 | 1 | 15 |   |   | 4 |   | 2 | 1 |   |   | 1 | 1 |   |   | 7 | 5 |   | 8 |
nonsynonymous SNV | 2 | 2 |   | 12 |   |   | 3 |   | 1 | 1 |   |   | 1 | 1 |   |   | 6 | 4 |   | 7 |
synonymous SNV |   | 1 | 1 | 3 |   |   | 1 |   | 1 |   |   |   |   |   |   |   | 1 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr22:40762493 | p.S415S,ADSL | 3 |
chr22:40745999 | p.I106I,ADSL | 2 |
chr22:40746000 | p.A381V,ADSL | 2 |
chr22:40760320 | p.I106T,ADSL | 2 |
chr22:40745930 | p.A322T,ADSL | 1 |
chr22:40761016 | p.P412L,ADSL | 1 |
chr22:40754925 | p.H107R,ADSL | 1 |
chr22:40759015 | p.L341W,ADSL | 1 |
chr22:40745953 | p.S112Y,ADSL | 1 |
chr22:40761043 | p.T347T,ADSL | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for ADSL |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
ADSL,ATF4,CDC45,CECR5,DRG1,EIF3D,JOSD1, MCM5,NHP2L1,PARVB,PDXP,PES1,PHF5A,POLR2F, RANBP1,RANGAP1,SAMM50,SMARCB1,TOMM22,TRMU,XRCC6 | ADSL,C14orf159,CCDC28B,YBX3,DYRK1B,EEF1A2,FEM1A, FHL3,GAMT,GAPDH,GOT1,IDI2,MYL6B,NOTUM, PFKM,RTN2,SHISA4,SMYD1,TCEA3,TPM2,TUBA4A | ||||
![]() | |||||
ADSL,BID,CECR5,DRG1,MRPL11,MRPL40,MRPS23, MRPS28,MRPS7,NHP2L1,NME1,PHF5A,POLR2F,PRDX3, RANBP1,RBX1,SLC25A17,TIMM8B,TOMM22,TXN2,XRCC6 | ADSL,ELP6,DRG1,GPN1,LSM2,MRPL11,MRPL43, MRPL49,MRPS15,MRPS7,POLE3,PPP1R8,RABEPK,RPL35, RPS18,RPS3A,RPS7,RPSA,RPSAP58,SNRPD2,STOML2 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for ADSL |
![]() |
DB Category | DB Name | DB's ID and Url link |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00145 | adenylosuccinate lyase | approved; nutraceutical | Glycine | ![]() | ![]() |
DB00130 | adenylosuccinate lyase | approved; nutraceutical; investigational | L-Glutamine | ![]() | ![]() |
Top |
Cross referenced IDs for ADSL |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |