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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ADSS |
Basic gene info. | Gene symbol | ADSS |
Gene name | adenylosuccinate synthase | |
Synonyms | ADEH|ADSS 2 | |
Cytomap | UCSC genome browser: 1q44 | |
Genomic location | chr1 :244571793-244615436 | |
Type of gene | protein-coding | |
RefGenes | NM_001126.3, | |
Ensembl id | ENSG00000035687 | |
Description | AMPSase 2IMP--aspartate ligase 2L-type adenylosuccinate synthetaseadSS 2adenylosuccinate synthetase (Ade(-)H-complementing)adenylosuccinate synthetase isozyme 2adenylosuccinate synthetase, acidic isozymeadenylosuccinate synthetase, liver isozyme | |
Modification date | 20141207 | |
dbXrefs | MIM : 103060 | |
HGNC : HGNC | ||
Ensembl : ENSG00000035687 | ||
HPRD : 00050 | ||
Vega : OTTHUMG00000040102 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADSS | |
BioGPS: 159 | ||
Gene Expression Atlas: ENSG00000035687 | ||
The Human Protein Atlas: ENSG00000035687 | ||
Pathway | NCI Pathway Interaction Database: ADSS | |
KEGG: ADSS | ||
REACTOME: ADSS | ||
ConsensusPathDB | ||
Pathway Commons: ADSS | ||
Metabolism | MetaCyc: ADSS | |
HUMANCyc: ADSS | ||
Regulation | Ensembl's Regulation: ENSG00000035687 | |
miRBase: chr1 :244,571,793-244,615,436 | ||
TargetScan: NM_001126 | ||
cisRED: ENSG00000035687 | ||
Context | iHOP: ADSS | |
cancer metabolism search in PubMed: ADSS | ||
UCL Cancer Institute: ADSS | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ADSS(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ADSS |
Familial Cancer Database: ADSS |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PURINE_METABOLISM KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM REACTOME_METABOLISM_OF_NUCLEOTIDES REACTOME_PURINE_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: ADSS |
MedGen: ADSS (Human Medical Genetics with Condition) | |
ClinVar: ADSS | |
Phenotype | MGI: ADSS (International Mouse Phenotyping Consortium) |
PhenomicDB: ADSS |
Mutations for ADSS |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ADSS | chr1 | 244595881 | 244596081 | ADSS | chr1 | 244598415 | 244598615 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADSS related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DB348377 | ADSS | 1 | 468 | 1 | 244572154 | 244572621 | JMJD1C | 465 | 537 | 10 | 64976007 | 64976078 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=30) | (# total SNVs=17) |
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(# total SNVs=2) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:244587341-244587341 | p.G165G | 5 |
chr1:244574619-244574619 | p.R430* | 4 |
chr1:244587324-244587324 | p.S171L | 3 |
chr1:244579341-244579341 | p.T370T | 2 |
chr1:244582125-244582125 | p.Y294Y | 2 |
chr1:244580947-244580947 | p.M351I | 2 |
chr1:244583488-244583488 | p.L258L | 2 |
chr1:244582071-244582071 | p.E312E | 1 |
chr1:244601077-244601077 | p.? | 1 |
chr1:244583561-244583561 | p.G234V | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 11 |   |   | 2 |   |   |   |   | 3 | 1 | 3 |   |   | 2 | 3 | 1 | 8 |
# mutation | 2 |   |   | 8 |   |   | 2 |   |   |   |   | 3 | 1 | 3 |   |   | 2 | 4 | 1 | 8 |
nonsynonymous SNV | 2 |   |   | 6 |   |   | 2 |   |   |   |   | 2 | 1 | 1 |   |   | 1 | 4 |   | 4 |
synonymous SNV |   |   |   | 2 |   |   |   |   |   |   |   | 1 |   | 2 |   |   | 1 |   | 1 | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:244587341 | p.G165G | 5 |
chr1:244583528 | p.E312E | 1 |
chr1:244600972 | p.E108Q | 1 |
chr1:244579368 | p.Q288E | 1 |
chr1:244586155 | p.F94L | 1 |
chr1:244614960 | p.G278D | 1 |
chr1:244579370 | p.A54T | 1 |
chr1:244587290 | p.V276D | 1 |
chr1:244614999 | p.E41K | 1 |
chr1:244580948 | p.R430Q | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ADSS |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ADSSL1,AK1,AKT1,BRF1,BTBD6,CCDC85C,CINP, CRIP2,GSTZ1,INF2,CEP170B,KLC1,MTA1,PACS2, PAK4,PWRN2,SIVA1,WBP1,WDR25,ZBTB42,ZFYVE21 | ADSSL1,MLIP,C8orf22,CA3,CKMT2,CORO6,ENAM, FBXO40,HRC,KLHL33,MYH1,MYOM1,PDE4DIP,PGAM2, PYGM,SLC25A34,SLC25A4,SYPL2,TMEM52,TNNT3,TRIM7 | ||||
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ADSSL1,ALPPL2,BEX1,MRGPRG-AS1,LAMP5,C3orf35,FAM218A, CMAHP,CNTFR,FGF3,KCP,LOC100131551,MAEL,MAGED4, NTF4,OOSP2,SACS,SCN2A,SPANXN2,SUMO1P1,TM9SF1 | AATK,ABCA4,ADSSL1,AGAP11,ALDH3B1,ALS2,AQP3, B3GALT2,MB21D2,MLXIPL,MPP6,PLLP,PNLIPRP2,RHBDL1, RNF141,SIRPA,SLC6A6,TEKT3,UNC93A,UPK3A,VNN1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ADSS |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB02109 | adenylosuccinate synthase | experimental | Hadacidin | ![]() | ![]() |
DB02493 | adenylosuccinate synthase | experimental | Hydantocidin-5'-Phosphate | ![]() | ![]() |
DB02666 | adenylosuccinate synthase | experimental | (C8-R)-Hydantocidin 5'-Phosphate | ![]() | ![]() |
DB02682 | adenylosuccinate synthase | experimental | 2-Deamino-6-Deoxy-6thiophosphite-5'-Phosphate Guanosine | ![]() | ![]() |
DB02836 | adenylosuccinate synthase | experimental | Guanosine 5'-Diphosphate 2':3'-Cyclic Monophosphate | ![]() | ![]() |
DB02954 | adenylosuccinate synthase | experimental | (Carboxyhydroxyamino)Ethanoic Acid | ![]() | ![]() |
DB03146 | adenylosuccinate synthase | experimental | 2-Deazo-6-Thiophosphate Guanosine-5'-Monophosphate | ![]() | ![]() |
DB04315 | adenylosuccinate synthase | experimental | Guanosine-5'-Diphosphate | ![]() | ![]() |
DB04460 | adenylosuccinate synthase | experimental | (C8-S)-Hydantocidin 5'-Phosphate | ![]() | ![]() |
DB04566 | adenylosuccinate synthase | experimental | Inosinic Acid | ![]() | ![]() |
DB04160 | adenylosuccinate synthase | experimental | Diphosphate | ![]() | ![]() |
DB00128 | adenylosuccinate synthase | approved; nutraceutical | L-Aspartic Acid | ![]() | ![]() |
DB03510 | adenylosuccinate synthase | experimental | 6-O-Phosphoryl Inosine Monophosphate | ![]() | ![]() |
DB02580 | adenylosuccinate synthase | experimental | 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane | ![]() | ![]() |
DB00864 | adenylosuccinate synthase | approved; investigational | Tacrolimus | ![]() | ![]() |
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Cross referenced IDs for ADSS |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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