|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DAD1 |
Basic gene info. | Gene symbol | DAD1 |
Gene name | defender against cell death 1 | |
Synonyms | OST2 | |
Cytomap | UCSC genome browser: 14q11.2 | |
Genomic location | chr14 :23033806-23058143 | |
Type of gene | protein-coding | |
RefGenes | NM_001344.3, | |
Ensembl id | ENSG00000129562 | |
Description | DAD-1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1oligosaccharyl transferase subunit DAD1oligosaccharyltransferase 2 homologoligosaccharyltransferase subunit 2 (non-catalytic) | |
Modification date | 20141207 | |
dbXrefs | MIM : 600243 | |
HGNC : HGNC | ||
Ensembl : ENSG00000129562 | ||
HPRD : 02589 | ||
Vega : OTTHUMG00000028685 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DAD1 | |
BioGPS: 1603 | ||
Gene Expression Atlas: ENSG00000129562 | ||
The Human Protein Atlas: ENSG00000129562 | ||
Pathway | NCI Pathway Interaction Database: DAD1 | |
KEGG: DAD1 | ||
REACTOME: DAD1 | ||
ConsensusPathDB | ||
Pathway Commons: DAD1 | ||
Metabolism | MetaCyc: DAD1 | |
HUMANCyc: DAD1 | ||
Regulation | Ensembl's Regulation: ENSG00000129562 | |
miRBase: chr14 :23,033,806-23,058,143 | ||
TargetScan: NM_001344 | ||
cisRED: ENSG00000129562 | ||
Context | iHOP: DAD1 | |
cancer metabolism search in PubMed: DAD1 | ||
UCL Cancer Institute: DAD1 | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for DAD1(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: DAD1 |
Familial Cancer Database: DAD1 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
REACTOME_METABOLISM_OF_PROTEINS |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: DAD1 |
MedGen: DAD1 (Human Medical Genetics with Condition) | |
ClinVar: DAD1 | |
Phenotype | MGI: DAD1 (International Mouse Phenotyping Consortium) |
PhenomicDB: DAD1 |
Mutations for DAD1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DAD1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AI094624 | DAD1 | 28 | 339 | 14 | 23033807 | 23044039 | YWHAE | 337 | 515 | 17 | 1265241 | 1268269 | |
BE537940 | GNB1 | 199 | 249 | 1 | 1717104 | 1717154 | DAD1 | 249 | 575 | 14 | 23044093 | 23058136 | |
BC013646 | GNB1 | 215 | 268 | 1 | 1717101 | 1717154 | DAD1 | 268 | 959 | 14 | 23033805 | 23058136 |
![]() |
Top |
![]() |
There's no copy number variation information in COSMIC data for this gene. |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=6) | (# total SNVs=0) |
![]() | |
(# total SNVs=3) | (# total SNVs=0) |
![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:23058005-23058005 | p.T20N | 1 |
chr14:23058021-23058021 | p.E15K | 1 |
chr14:23058038-23058038 | p.I9S | 1 |
chr14:23044008-23044010 | p.V112delV | 1 |
chr14:23058043-23058044 | p.S7fs*89 | 1 |
chr14:23044032-23044032 | p.H105Y | 1 |
chr14:23044071-23044071 | p.R92* | 1 |
chr14:23044096-23044096 | p.A83A | 1 |
chr14:23044097-23044097 | p.A83V | 1 |
chr14:23057891-23057891 | p.S58L | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 2 |   |   |   |   |   |   |   | 1 |   |   |   |   | 1 |   |   | 1 |
# mutation |   |   |   | 2 |   |   |   |   |   |   |   | 1 |   |   |   |   | 1 |   |   | 1 |
nonsynonymous SNV |   |   |   | 2 |   |   |   |   |   |   |   | 1 |   |   |   |   | 1 |   |   | 1 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:23044032 | p.H105Y | 1 |
chr14:23057900 | p.S55Y | 1 |
chr14:23057909 | p.P52L | 1 |
chr14:23058005 | p.T20N | 1 |
chr14:23058021 | p.E15K | 1 |
chr14:23058038 | p.I9S | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for DAD1 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |
C14orf119,C14orf2,CHMP4A,COX16,DAD1,DHRS4,DHRS4L2, EMC9,FKBP3,MRPL52,NEDD8,NGDN,ORMDL2,OXA1L, PRMT5,PSMB5,PSMC1,RABGGTA,RNF181,RPL36AL,TM9SF1 | ATP6V0E1,C14orf119,BRK1,COMMD6,DAD1,DYNLRB1,GABARAP, GTF2A2,JAGN1,KRTCAP2,LAPTM4A,MPV17,MYL12B,NOP10, RAC1,SPCS1,SUMO1,TMEM60,TOMM5,TOMM6,TXNDC12 |
![]() | |
C14orf119,GSKIP,APOPT1,C14orf166,C14orf2,CINP,CNIH1, DAD1,ERH,GMPR2,ISCA2,MRPL52,NEDD8,OSGEP, PNP,PSMA6,PSMB5,PSMC6,RPL36AL,SCFD1,SIVA1 | C14orf119,SLIRP,C14orf166,EMC7,COA6,COX7A2,DAD1, LAMTOR5,MMADHC,MRPL22,NDUFB4,NDUFB6,NDUFV2,PSMB1, PSMC6,PSMD13,PSMD8,RBX1,TXNL1,UBL5,YWHAE |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for DAD1 |
There's no related Drug. |
Top |
Cross referenced IDs for DAD1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |