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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DGKH |
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Phenotypic Information for DGKH(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: DGKH |
Familial Cancer Database: DGKH |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLYCEROLIPID_METABOLISM KEGG_GLYCEROPHOSPHOLIPID_METABOLISM |
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OMIM | 604071; gene. 604071; gene. |
Orphanet | |
Disease | KEGG Disease: DGKH |
MedGen: DGKH (Human Medical Genetics with Condition) | |
ClinVar: DGKH | |
Phenotype | MGI: DGKH (International Mouse Phenotyping Consortium) |
PhenomicDB: DGKH |
Mutations for DGKH |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
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- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | DGKH | chr13 | 42739494 | 42739514 | C17orf96 | chr17 | 36830559 | 36830579 |
pancreas | DGKH | chr13 | 42728046 | 42728246 | chr13 | 37058756 | 37058956 | |
pancreas | DGKH | chr13 | 42747629 | 42747649 | ENOX1 | chr13 | 44022771 | 44022791 |
prostate | DGKH | chr13 | 42647252 | 42647252 | chr13 | 47092439 | 47092439 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DGKH related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BF373800 | DGKH | 1 | 67 | 13 | 42742071 | 42742138 | DGKH | 58 | 140 | 13 | 42741978 | 42742060 | |
BF930562 | SOX6 | 10 | 159 | 11 | 16594593 | 16594743 | DGKH | 152 | 321 | 13 | 42681634 | 42681803 | |
W80598 | ENTPD1 | 114 | 133 | 10 | 97602912 | 97602931 | DGKH | 134 | 418 | 13 | 42811785 | 42812066 | |
BG571504 | UBQLN1 | 1 | 423 | 9 | 86306517 | 86306939 | DGKH | 418 | 621 | 13 | 42708464 | 42708668 | |
AW818534 | GDA | 2 | 103 | 9 | 74822564 | 74822665 | DGKH | 93 | 167 | 13 | 42774590 | 42774664 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 4 |   | 1 | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 4 |   | 1 | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=90) | (# total SNVs=28) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr13:42772717-42772717 | p.P757P | 4 |
chr13:42793918-42793918 | p.S1144G | 4 |
chr13:42734172-42734172 | p.E252G | 4 |
chr13:42793919-42793919 | p.S1144N | 3 |
chr13:42733403-42733403 | p.V208V | 3 |
chr13:42789733-42789733 | p.T1048S | 3 |
chr13:42733400-42733400 | p.? | 3 |
chr13:42793377-42793377 | p.S1075S | 2 |
chr13:42793920-42793920 | p.S1144R | 2 |
chr13:42761271-42761271 | p.A542V | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 1 |   | 25 | 1 |   | 4 |   | 7 |   |   | 9 | 1 | 4 |   | 1 | 9 | 13 | 1 | 13 |
# mutation | 3 | 1 |   | 21 | 1 |   | 4 |   | 7 |   |   | 10 | 1 | 4 |   | 1 | 12 | 14 | 1 | 13 |
nonsynonymous SNV | 2 | 1 |   | 19 | 1 |   | 4 |   | 4 |   |   | 8 |   | 4 |   | 1 | 8 | 10 | 1 | 11 |
synonymous SNV | 1 |   |   | 4 |   |   |   |   | 3 |   |   | 2 | 1 |   |   |   | 4 | 4 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr13:42793918 | p.S899G,DGKH | 4 |
chr13:42793919 | p.S899N,DGKH | 3 |
chr13:42803249 | p.S830S,DGKH | 2 |
chr13:42783190 | p.V55M,DGKH | 2 |
chr13:42761271 | p.R556Q,DGKH | 2 |
chr13:42773954 | p.S899S,DGKH | 2 |
chr13:42793920 | p.Q654Q,DGKH | 2 |
chr13:42795459 | p.Y1032H,DGKH | 2 |
chr13:42793377 | p.A297V,DGKH | 2 |
chr13:42729884 | p.R1038H,DGKH | 2 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for DGKH |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AKAP11,ASXL2,BIRC6,GPATCH2L,CDKL5,DGKH,FER, GTF2A1,VWA8,MAP3K2,KMT2A,NBEAL1,RAD54L2,REST, SNX29,SMG1,STRN,TTBK2,ZBTB37,ZDHHC20,ZNF81 | ASH1L,BIRC6,CDKL5,DGKH,EP300,FAM63B,HMBOX1, EPG5,LPP,KMT2C,KMT2A,MYO9A,MYSM1,KAT6A, NBEAL1,SMG1,UBXN7,VPS13B,WDFY3,ZKSCAN8,ZNF81 |
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AKAP11,ASH1L,ASXL2,DGKH,DKFZp686O24166,VWA8,MPHOSPH8, MYCBP2,MYSM1,PARP4,RASA2,RBM26,SLC7A1,SMG1, SPATA13,USP12,UTP14C,XPO4,ZC3H13,ZDHHC20,ZMYM2 | BDP1,FAM208B,C17orf85,CELF1,CLOCK,DDI2,DGKH, DICER1,AGO2,ELK4,KIAA0754,MDN1,MUC4,MUC5B, POLR3A,PTPRG,RBM25,RC3H2,RIF1,SHROOM4,SUMO4 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for DGKH |
There's no related Drug. |
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Cross referenced IDs for DGKH |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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