Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for DGKQ
Basic gene info.Gene symbolDGKQ
Gene namediacylglycerol kinase, theta 110kDa
SynonymsDAGK|DAGK4|DAGK7
CytomapUCSC genome browser: 4p16.3
Genomic locationchr4 :952671-967348
Type of geneprotein-coding
RefGenesNM_001347.3,
Ensembl idENSG00000145214
DescriptionDAG kinase thetaDGK-thetadiacylglycerol kinase thetadiglyceride kinase theta
Modification date20141207
dbXrefs MIM : 601207
HGNC : HGNC
Ensembl : ENSG00000145214
HPRD : 03127
Vega : OTTHUMG00000088629
ProteinUniProt: P52824
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DGKQ
BioGPS: 1609
Gene Expression Atlas: ENSG00000145214
The Human Protein Atlas: ENSG00000145214
PathwayNCI Pathway Interaction Database: DGKQ
KEGG: DGKQ
REACTOME: DGKQ
ConsensusPathDB
Pathway Commons: DGKQ
MetabolismMetaCyc: DGKQ
HUMANCyc: DGKQ
RegulationEnsembl's Regulation: ENSG00000145214
miRBase: chr4 :952,671-967,348
TargetScan: NM_001347
cisRED: ENSG00000145214
ContextiHOP: DGKQ
cancer metabolism search in PubMed: DGKQ
UCL Cancer Institute: DGKQ
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for DGKQ(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: DGKQ
Familial Cancer Database: DGKQ
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCEROLIPID_METABOLISM
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM

check002.gifOthers
OMIM 601207; gene.
Orphanet
DiseaseKEGG Disease: DGKQ
MedGen: DGKQ (Human Medical Genetics with Condition)
ClinVar: DGKQ
PhenotypeMGI: DGKQ (International Mouse Phenotyping Consortium)
PhenomicDB: DGKQ

Mutations for DGKQ
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DGKQ related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample          1   1  
GAIN (# sample)              1  
LOSS (# sample)          1      
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=21)
Stat. for Synonymous SNVs
(# total SNVs=15)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:961373-961373p.V317V3
chr4:955832-955832p.D751E2
chr4:957013-957013p.L600L2
chr4:955317-955317p.E838K1
chr4:960963-960963p.L392L1
chr4:961568-961568p.D278D1
chr4:956367-956367p.A690A1
chr4:954842-954842p.P908A1
chr4:959075-959075p.A541A1
chr4:955350-955350p.D827N1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample33 22 511  21  273 4
# mutation33 22 611  21  273 4
nonsynonymous SNV21 11 411   1  241 2
synonymous SNV12 11 2    2    32 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:955561p.E464K1
chr4:956666p.L711L1
chr4:954842p.L392L1
chr4:960969p.E706G1
chr4:955614p.R390W1
chr4:956989p.P908A1
chr4:954870p.S699F1
chr4:961348p.E326K1
chr4:955780p.P898P1
chr4:957013p.G694S1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for DGKQ in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for DGKQ

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACAP3,TMEM259,CAPN10,CTBP1,DGKQ,FAM53A,FLYWCH1,
GAK,IDUA,MAEA,MFSD10,MICALL2,PLEKHH3,RGS12,
RHOT2,SLC26A1,TELO2,TMEM129,TMEM175,TNIP2,NELFA
ANAPC2,ARFGAP1,B3GAT3,C17orf70,CAPN10,CTDP1,DGKQ,
E4F1,GAK,LRWD1,NDOR1,PNKP,PUS1,RABEP2,
RANGAP1,RHOT2,SLC12A9,TELO2,TRIM11,ZBTB17,ZNF513

ARHGEF16,BAIAP2L2,CDC42BPG,CGN,CRIPAK,CTBP1,DGKQ,
ERN2,GAK,UVSSA,MYO7B,PCGF3,PLEKHA6,SH3BP2,
TADA2B,TJP3,TMEM129,TNIP2,TSC2,ZBTB7B,ZFYVE28
ABR,ADCY6,ARHGAP27,ARHGEF16,CC2D1A,CTDP1,DGKQ,
DQX1,GRAMD4,HDAC10,KIAA1522,CAMSAP3,MAST3,MGAT4B,
PFKL,RAB40C,RAPGEFL1,SIPA1L3,SLC26A6,TPCN1,ZNF784
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for DGKQ


There's no related Drug.
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Cross referenced IDs for DGKQ
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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