Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AKR1C2
Basic gene info.Gene symbolAKR1C2
Gene namealdo-keto reductase family 1, member C2
SynonymsAKR1C-pseudo|BABP|DD|DD-2|DD/BABP|DD2|DDH2|HAKRD|HBAB|MCDR2|SRXY8|TDD
CytomapUCSC genome browser: 10p15-p14
Genomic locationchr10 :5042102-5046206
Type of geneprotein-coding
RefGenesNM_001135241.2,
NM_001354.5,NM_205845.2,
Ensembl idENSG00000265231
Description3-alpha-HSD3aldo-keto reductase family 1 member C2chlordecone reductase homolog HAKRDdihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type IIIpseudo-chlordecone reductasetesticular 17,20-desmolase deficien
Modification date20141207
dbXrefs MIM : 600450
HGNC : HGNC
Ensembl : ENSG00000151632
HPRD : 11857
Vega : OTTHUMG00000017584
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR1C2
BioGPS: 1646
Gene Expression Atlas: ENSG00000265231
The Human Protein Atlas: ENSG00000265231
PathwayNCI Pathway Interaction Database: AKR1C2
KEGG: AKR1C2
REACTOME: AKR1C2
ConsensusPathDB
Pathway Commons: AKR1C2
MetabolismMetaCyc: AKR1C2
HUMANCyc: AKR1C2
RegulationEnsembl's Regulation: ENSG00000265231
miRBase: chr10 :5,042,102-5,046,206
TargetScan: NM_001135241
cisRED: ENSG00000265231
ContextiHOP: AKR1C2
cancer metabolism search in PubMed: AKR1C2
UCL Cancer Institute: AKR1C2
Assigned class in ccmGDBC

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Phenotypic Information for AKR1C2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AKR1C2
Familial Cancer Database: AKR1C2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: AKR1C2
MedGen: AKR1C2 (Human Medical Genetics with Condition)
ClinVar: AKR1C2
PhenotypeMGI: AKR1C2 (International Mouse Phenotyping Consortium)
PhenomicDB: AKR1C2

Mutations for AKR1C2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AKR1C2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=19

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=20)
Stat. for Synonymous SNVs
(# total SNVs=30)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr10:5037574-5037574p.L261L19
chr10:5046013-5046013p.Y5Y6
chr10:5040936-5040936p.M151V4
chr10:5045953-5045953p.A25A2
chr10:5043729-5043729p.E77*2
chr10:5040898-5040898p.I163M2
chr10:5041445-5041445p.D132Y2
chr10:5043870-5043870p.P30S1
chr10:5037992-5037992p.V212V1
chr10:5042749-5042749p.S121F1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 323    1  1    3  4
# mutation 313    1  1    3  4
nonsynonymous SNV 312       1    3  2
synonymous SNV   1    1          2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr10:5045953p.A25A,AKR1C22
chr10:5040936p.M151V,AKR1C22
chr10:5041445p.D132Y,AKR1C22
chr10:5038048p.S121F,AKR1C21
chr10:5040898p.P119S,AKR1C21
chr10:5045982p.D109D,AKR1C21
chr10:5042749p.S87G,AKR1C21
chr10:5042756p.A44V,AKR1C21
chr10:5042784p.P30S,AKR1C21
chr10:5042852p.V29G,AKR1C21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AKR1C2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AKR1C2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACSM1,AFMID,AKR1C1,AKR1C2,AKR1D1,C15orf43,CLPSL1,
C6orf223,CDC42EP5,EYS,GGT1,GGT3P,GGTLC1,GGTLC2,
HAAO,HPD,KCNG2,SERHL2,SERHL,SPINK8,SULT1C3
AIFM2,AKR1C1,AKR1C2,AKR1C3,ANXA5,APBB1IP,BHMT2,
BTD,DHDDS,EPHX1,GCOM1,GLYAT,ITGB1BP1,ITIH5,
ITPK1,MRAS,PALMD,PYGL,RETSAT,TK2,VKORC1L1

ACSM5,ADIPOQ,AKR1C1,AKR1C2,AQP7,CD300LG,CD36,
EPB42,FABP4,FMO2,LBP,LIPE,LOC339524,MRAP,
PLIN1,PLIN4,PTCHD3,SPTA1,THRSP,TTTY9B,TUSC5
ACAD11,ACBD4,AKR1C2,AKR1C3,BDH2,RITA1,C1orf189,
CCNG1,COX6A2,CPNE7,CRIP3,DEGS2,GDPD1,GPX4,
HSD17B11,LPO,LRRC28,SLC25A34,SLC30A2,UGT1A1,UNC93A
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AKR1C2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00157aldo-keto reductase family 1, member C2approved; nutraceuticalNADH
DB01586aldo-keto reductase family 1, member C2approved; investigationalUrsodeoxycholic acid
DB03461aldo-keto reductase family 1, member C2experimental2'-Monophosphoadenosine 5'-Diphosphoribose
DB07768aldo-keto reductase family 1, member C2experimental(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE


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Cross referenced IDs for AKR1C2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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