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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for NQO1 |
Basic gene info. | Gene symbol | NQO1 |
Gene name | NAD(P)H dehydrogenase, quinone 1 | |
Synonyms | DHQU|DIA4|DTD|NMOR1|NMORI|QR1 | |
Cytomap | UCSC genome browser: 16q22.1 | |
Genomic location | chr16 :69743303-69760533 | |
Type of gene | protein-coding | |
RefGenes | NM_000903.2, NM_001025433.1,NM_001025434.1,NM_001286137.1, | |
Ensembl id | ENSG00000181019 | |
Description | DT-diaphoraseNAD(P)H dehydrogenase [quinone] 1NAD(P)H:Quinone acceptor oxidoreductase type 1NAD(P)H:menadione oxidoreductase 1NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone oxireductaseazoreductasediaphorase (NADH/NADPH) (cytochrome b-5 reductase) | |
Modification date | 20141222 | |
dbXrefs | MIM : 125860 | |
HGNC : HGNC | ||
Ensembl : ENSG00000181019 | ||
HPRD : 00518 | ||
Vega : OTTHUMG00000137575 | ||
Protein | UniProt: P15559 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NQO1 | |
BioGPS: 1728 | ||
Gene Expression Atlas: ENSG00000181019 | ||
The Human Protein Atlas: ENSG00000181019 | ||
Pathway | NCI Pathway Interaction Database: NQO1 | |
KEGG: NQO1 | ||
REACTOME: NQO1 | ||
ConsensusPathDB | ||
Pathway Commons: NQO1 | ||
Metabolism | MetaCyc: NQO1 | |
HUMANCyc: NQO1 | ||
Regulation | Ensembl's Regulation: ENSG00000181019 | |
miRBase: chr16 :69,743,303-69,760,533 | ||
TargetScan: NM_000903 | ||
cisRED: ENSG00000181019 | ||
Context | iHOP: NQO1 | |
cancer metabolism search in PubMed: NQO1 | ||
UCL Cancer Institute: NQO1 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for NQO1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: NQO1 |
Familial Cancer Database: NQO1 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | 125860; gene. |
Orphanet | |
Disease | KEGG Disease: NQO1 |
MedGen: NQO1 (Human Medical Genetics with Condition) | |
ClinVar: NQO1 | |
Phenotype | MGI: NQO1 (International Mouse Phenotyping Consortium) |
PhenomicDB: NQO1 |
Mutations for NQO1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
- For Intra-chromosomal Variations |
There's no intra-chromosomal structural variation. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | NQO1 | chr16 | 69744974 | 69744994 | CHST3 | chr10 | 73755735 | 73755755 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NQO1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DA648735 | SNHG6 | 1 | 75 | 8 | 67834709 | 67834783 | NQO1 | 76 | 546 | 16 | 69748934 | 69760463 | |
BM755010 | NQO1 | 17 | 136 | 16 | 69760336 | 69760461 | TTC37 | 136 | 482 | 5 | 94814082 | 94820550 | |
CB159668 | NQO1 | 1 | 121 | 16 | 69747001 | 69748955 | NQO1 | 116 | 565 | 16 | 69744805 | 69747000 | |
BQ220009 | FAM155A | 85 | 136 | 13 | 108363673 | 108363730 | NQO1 | 131 | 866 | 16 | 69743316 | 69744046 | |
BM983726 | NQO1 | 18 | 191 | 16 | 69744749 | 69744922 | DYRK1A | 184 | 279 | 21 | 38887379 | 38887473 | |
DB537013 | NQO1 | 1 | 297 | 16 | 69744221 | 69744518 | XRN1 | 297 | 331 | 3 | 142053702 | 142053736 | |
BU189113 | NQO1 | 14 | 93 | 16 | 69744299 | 69744378 | NQO1 | 90 | 859 | 16 | 69743558 | 69744323 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=15) | (# total SNVs=8) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr16:69745102-69745102 | p.R201Q | 2 |
chr16:69745145-69745145 | p.P187S | 2 |
chr16:69752312-69752312 | p.M45L | 2 |
chr16:69745073-69745073 | p.R211C | 2 |
chr16:69752084-69752084 | p.S82I | 1 |
chr16:69752397-69752397 | p.T16T | 1 |
chr16:69752129-69752129 | p.Q67P | 1 |
chr16:69760326-69760329 | p.? | 1 |
chr16:69745175-69745175 | p.L177V | 1 |
chr16:69752137-69752137 | p.A64A | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   | 2 |   |   |   |   |   |   |   | 3 | 1 |   |   |   | 1 | 3 |   | 4 |
# mutation |   | 1 |   | 2 |   |   |   |   |   |   |   | 5 | 1 |   |   |   | 1 | 3 |   | 6 |
nonsynonymous SNV |   | 1 |   | 1 |   |   |   |   |   |   |   | 2 |   |   |   |   | 1 | 3 |   | 3 |
synonymous SNV |   |   |   | 1 |   |   |   |   |   |   |   | 3 | 1 |   |   |   |   |   |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr16:69745102 | p.G125W,NQO1 | 1 |
chr16:69752360 | p.Y118H,NQO1 | 1 |
chr16:69745103 | p.M117I,NQO1 | 1 |
chr16:69752376 | p.F138F,NQO1 | 1 |
chr16:69745175 | p.A131V,NQO1 | 1 |
chr16:69746963 | p.A64A,NQO1 | 1 |
chr16:69746984 | p.K59K,NQO1 | 1 |
chr16:69744882 | p.K202K,NQO1 | 1 |
chr16:69746985 | p.L42L,NQO1 | 1 |
chr16:69744912 | p.I192M,NQO1 | 1 |
Other DBs for Point Mutations |
Copy Number for NQO1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for NQO1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
AP1G1,ATP6V0D1,C16orf70,CDH1,COG4,COG8,CTCF, CYB5B,ESRP2,EXOSC6,FAM192A,G6PD,GOT2,HSBP1, IST1,ME1,NQO1,ORMDL2,POLR2C,SQSTM1,UGT1A6 | ABCC2,ADAM2,AWAT2,C6orf223,DHRS2,FAR2,G6PD, HIST1H2BC,HPGD,HSD3B1,NQO1,PAPSS2,PNLIPRP3,SCP2, SERHL2,SLC5A11,TARP,TMCC3,TMPRSS11F,TSKU,UGT2B28 | ||||
AK1,ANXA4,ANXA9,TLDC2,CYSTM1,CLRN3,COPZ1, HEBP2,MAPK3,METTL7B,MGST2,MGST3,NQO1,OSGIN1, PNKD,SQSTM1,TM4SF5,TMCO1,EMC3,VDAC1,YIPF4 | ABHD5,ASB11,CA2,CSN1S1,CSTB,CYP2B7P,MICU2, ETNK1,GDPD3,IQCD,NQO1,OASL,SLC25A24,SLC25A33, SLC4A9,SRI,TAT,TMEM56,TPMT,UBE2A,UGDH |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for NQO1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | P15559; -. |
Chemistry | ChEMBL | CHEMBL3623; -. |
Organism-specific databases | PharmGKB | PA31744; -. |
Organism-specific databases | CTD | 1728; -. |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00170 | NAD(P)H dehydrogenase, quinone 1 | approved; nutraceutical | Menadione | ||
DB00266 | NAD(P)H dehydrogenase, quinone 1 | approved | Dicumarol | ||
DB01927 | NAD(P)H dehydrogenase, quinone 1 | experimental | Duroquinone | ||
DB02395 | NAD(P)H dehydrogenase, quinone 1 | experimental | 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol | ||
DB02400 | NAD(P)H dehydrogenase, quinone 1 | experimental | 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione | ||
DB02633 | NAD(P)H dehydrogenase, quinone 1 | experimental | Cibacron Blue | ||
DB03147 | NAD(P)H dehydrogenase, quinone 1 | experimental | Flavin-Adenine Dinucleotide | ||
DB03626 | NAD(P)H dehydrogenase, quinone 1 | experimental | 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione | ||
DB04090 | NAD(P)H dehydrogenase, quinone 1 | experimental | 2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione | ||
DB04392 | NAD(P)H dehydrogenase, quinone 1 | experimental | Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] | ||
DB07385 | NAD(P)H dehydrogenase, quinone 1 | experimental | 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE | ||
DB00818 | NAD(P)H dehydrogenase, quinone 1 | approved; investigational | Propofol | ||
DB00997 | NAD(P)H dehydrogenase, quinone 1 | approved; investigational | Doxorubicin | ||
DB00515 | NAD(P)H dehydrogenase, quinone 1 | approved | Cisplatin | ||
DB00305 | NAD(P)H dehydrogenase, quinone 1 | approved | Mitomycin | ||
DB00773 | NAD(P)H dehydrogenase, quinone 1 | approved | Etoposide | ||
DB00445 | NAD(P)H dehydrogenase, quinone 1 | approved | Epirubicin | ||
DB03033 | NAD(P)H dehydrogenase, quinone 1 | experimental | 1-Methyloxy-4-Sulfone-Benzene | ||
DB01022 | NAD(P)H dehydrogenase, quinone 1 | approved | Phytonadione |
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Cross referenced IDs for NQO1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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