Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for DIO1

Basic gene info.	Gene symbol	DIO1
	Gene name	deiodinase, iodothyronine, type I
	Synonyms	5DI\|TXDI1
	Cytomap	UCSC genome browser: 1p33-p32
	Genomic location	chr1 :54359860-54376759
	Type of gene	protein-coding
	RefGenes	NM_000792.5, NM_001039715.1,NM_001039716.1,NM_213593.3,
	Ensembl id	ENSG00000211452
	Description	DIOIiodothyronine deiodinase type 1thyroxine deiodinase type I (selenoprotein)type 1 DItype I iodothyronine deiodinasetype-I 5'-deiodinase
	Modification date	20141207
dbXrefs	MIM : 147892
	HGNC : HGNC
	Ensembl : ENSG00000211452
	HPRD : 01002
	Vega : OTTHUMG00000008435
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_DIO1
	BioGPS: 1733
	Gene Expression Atlas: ENSG00000211452
	The Human Protein Atlas: ENSG00000211452
Pathway	NCI Pathway Interaction Database: DIO1
	KEGG: DIO1
	REACTOME: DIO1
	ConsensusPathDB
	Pathway Commons: DIO1
Metabolism	MetaCyc: DIO1
	HUMANCyc: DIO1
Regulation	Ensembl's Regulation: ENSG00000211452
	miRBase: chr1 :54,359,860-54,376,759
	TargetScan: NM_000792
	cisRED: ENSG00000211452
Context	iHOP: DIO1
	cancer metabolism search in PubMed: DIO1
	UCL Cancer Institute: DIO1
Assigned class in ccmGDB	C

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Phenotypic Information for DIO1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: DIO1
	Familial Cancer Database: DIO1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

Others
OMIM
Orphanet
Disease	KEGG Disease: DIO1
	MedGen: DIO1 (Human Medical Genetics with Condition)
	ClinVar: DIO1
Phenotype	MGI: DIO1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: DIO1

Mutations for DIO1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
breast	DIO1	chr1	54369421	54369421		chr1	54378944	54378944

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DIO1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

DA641783

LOC100507412

106

112074

112179

DIO1

107

534

54359860

54370405

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=18)	Stat. for Synonymous SNVs (# total SNVs=10)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:54359925-54359925	p.W14*	3
chr1:54360102-54360102	p.F73F	3
chr1:54375643-54375643	p.R193C	2
chr1:54359887-54359887	p.G2R	1
chr1:54371967-54371967	p.K179K	1
chr1:54360030-54360030	p.G49G	1
chr1:54371785-54371787	p.N120delN	1
chr1:54359894-54359894	p.P4L	1
chr1:54375618-54375618	p.P184P	1
chr1:54360051-54360051	p.F56F	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	1		4								3	1				4	1	1	7
# mutation	1	1		4								3	1				4	1	1	6
nonsynonymous SNV				1								2					2	1	1	5
synonymous SNV	1	1		3								1	1				2			1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:54360102	p.F73F	3
chr1:54375643	p.R193C	2
chr1:54359887	p.G2R	1
chr1:54360179	p.I176I	1
chr1:54359913	p.L10L	1
chr1:54360202	p.K179K	1
chr1:54360005	p.I41N	1
chr1:54371825	p.P184P	1
chr1:54360012	p.A43A	1
chr1:54371895	p.M44T	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for DIO1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for DIO1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


CA12,CHPT1,COQ7,DIO1,GPHN,HSPB8,KRT33A, KRT37,LRIG1,MCEE,NKIRAS1,PEX12,PEX2,PTGER3, RMND1,SPCS1,STC2,SYBU,TNK1,TPSG1,WWP1	ASCL2,BAGE,C11orf85,C2orf50,CNTD2,DIO1,GALNTL6, GATA5,KCNF1,KCNK15,MCHR1,MYT1,NTSR1,OR56A3, PSCA,SLC7A13,SPANXC,VSTM2A,ABHD11-AS1,WBSCR28,WNT3A

C3P1,CACNG1,ACKR2___ACKR4,CD7,CXorf49B,DIO1,DMRTB1, FLJ35024,GSTA3,LOC100133669,MS4A15,psiTPTE22,RDH8,RMST, S100A7A,STOML3,TESK2,TFAP2E,VSIG10L,WIPF3,YBX1	ADORA3,AKR1B1,ALOX15B,ANTXRL,C15orf43,CA5A,DIO1, ITGA10,KIR2DL3,LILRA2,LOC731789,LY6K,MC3R,MERTK, NDRG2,OR1L6,P2RY14,SDHAP2,SIGLEC8,SP9,TRMT12

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for DIO1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00451	deiodinase, iodothyronine, type I	approved	Levothyroxine

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Cross referenced IDs for DIO1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information