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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DLST |
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Phenotypic Information for DLST(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: DLST |
Familial Cancer Database: DLST |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: DLST |
MedGen: DLST (Human Medical Genetics with Condition) | |
ClinVar: DLST | |
Phenotype | MGI: DLST (International Mouse Phenotyping Consortium) |
PhenomicDB: DLST |
Mutations for DLST |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DLST related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BP276043 | DLST | 1 | 523 | 14 | 75348616 | 75359576 | LOC100507412 | 519 | 581 | ? | 110594 | 110656 | |
DA537507 | DLST | 1 | 226 | 14 | 75348625 | 75356055 | ELAC2 | 222 | 567 | 17 | 12915070 | 12920440 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=30) | (# total SNVs=9) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:75367835-75367835 | p.V376I | 3 |
chr14:75366634-75366634 | p.D304Y | 3 |
chr14:75349287-75349287 | p.? | 2 |
chr14:75361033-75361033 | p.R231W | 2 |
chr14:75367834-75367834 | p.G375G | 2 |
chr14:75355994-75355994 | p.T72T | 1 |
chr14:75359606-75359606 | p.A171V | 1 |
chr14:75348660-75348660 | p.L2L | 1 |
chr14:75361058-75361058 | p.K239T | 1 |
chr14:75356020-75356020 | p.S81F | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 2 |   | 6 |   |   | 4 |   | 1 |   |   | 2 | 2 | 1 |   |   | 3 | 5 |   | 7 |
# mutation | 2 | 3 |   | 5 |   |   | 4 |   | 1 |   |   | 2 | 2 | 1 |   |   | 3 | 5 |   | 10 |
nonsynonymous SNV | 1 | 3 |   | 4 |   |   | 3 |   | 1 |   |   | 2 | 1 | 1 |   |   |   | 4 |   | 8 |
synonymous SNV | 1 |   |   | 2 |   |   | 1 |   |   |   |   |   | 1 |   |   |   | 3 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:75348660 | p.L2L,DLST | 2 |
chr14:75369021 | p.R231W | 2 |
chr14:75361033 | p.L450L | 2 |
chr14:75357796 | p.Q183H | 1 |
chr14:75361079 | p.V376I | 1 |
chr14:75367868 | p.I386V | 1 |
chr14:75357821 | p.G216D | 1 |
chr14:75361090 | p.N387D | 1 |
chr14:75349302 | p.R224W | 1 |
chr14:75367869 | p.N387S | 1 |
Other DBs for Point Mutations |
Copy Number for DLST in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for DLST |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ALKBH1,ANGEL1,NRDE2,DCAF5,DDX24,DLST,EIF2B2, EIF2S1,EXD2,FCF1,AREL1,MED6,MTHFD1,NUMB, PSEN1,SNW1,TMED10,TTLL5,VIPAS39,YLPM1,ZNF410 | ACAA2,ADHFE1,CS,DLST,ECHS1,GPI,GPT2, HADH,HADHA,KIAA0408,PDHA1,PDK2,GATB,PFKFB1, PLIN5,RNF157,SLC25A23,SLC2A4,SLC6A8,STBD1,SUCLG1 |
ATP5A1,ATP5B,ATPAF2,GSKIP,COQ6,DLST,EIF2B2, EIF2S1,EIF4A1,FNTB,GLRX5,GNPNAT1,PCCB,PLEK2, PNP,PRMT5,RABGGTA,RPL36AL,SCO1,TMED10,TMX1 | AIMP2,ATP5A1,ATP5C1,ATP5H,ATP5O,COPS5,COQ9, DLST,IDH3B,LOC645166,LOC654342,MAPK8,MTCH2,NDUFA12, NDUFAB1,NDUFB9,POLDIP2,SDHB,SLC14A2,SUCLG1,UQCRC2 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for DLST |
There's no related Drug. |
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Cross referenced IDs for DLST |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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