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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for AGT |
Basic gene info. | Gene symbol | AGT |
Gene name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | |
Synonyms | ANHU|SERPINA8 | |
Cytomap | UCSC genome browser: 1q42.2 | |
Genomic location | chr1 :230838271-230850336 | |
Type of gene | protein-coding | |
RefGenes | NM_000029.3, | |
Ensembl id | ENSG00000135744 | |
Description | alpha-1 antiproteinase, antitrypsinangiotensin Iangiotensin IIangiotensinogenpre-angiotensinogenserine (or cysteine) proteinase inhibitorserpin A8 | |
Modification date | 20141222 | |
dbXrefs | MIM : 106150 | |
HGNC : HGNC | ||
Ensembl : ENSG00000135744 | ||
HPRD : 00106 | ||
Vega : OTTHUMG00000037757 | ||
Protein | UniProt: P01019 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AGT | |
BioGPS: 183 | ||
Gene Expression Atlas: ENSG00000135744 | ||
The Human Protein Atlas: ENSG00000135744 | ||
Pathway | NCI Pathway Interaction Database: AGT | |
KEGG: AGT | ||
REACTOME: AGT | ||
ConsensusPathDB | ||
Pathway Commons: AGT | ||
Metabolism | MetaCyc: AGT | |
HUMANCyc: AGT | ||
Regulation | Ensembl's Regulation: ENSG00000135744 | |
miRBase: chr1 :230,838,271-230,850,336 | ||
TargetScan: NM_000029 | ||
cisRED: ENSG00000135744 | ||
Context | iHOP: AGT | |
cancer metabolism search in PubMed: AGT | ||
UCL Cancer Institute: AGT | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for AGT(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: AGT |
Familial Cancer Database: AGT |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | 106150; gene. 145500; phenotype. 267430; phenotype. |
Orphanet | 243761; Essential hypertension. 97369; Renal tubular dysgenesis of genetic origin. |
Disease | KEGG Disease: AGT |
MedGen: AGT (Human Medical Genetics with Condition) | |
ClinVar: AGT | |
Phenotype | MGI: AGT (International Mouse Phenotyping Consortium) |
PhenomicDB: AGT |
Mutations for AGT |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | AGT | chr1 | 230841684 | 230841704 | chr1 | 230865748 | 230865768 | |
ovary | AGT | chr1 | 230848219 | 230848239 | AGT | chr1 | 230848329 | 230848349 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AGT related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DA142897 | GABBR2 | 1 | 83 | 9 | 101051796 | 101051878 | AGT | 84 | 560 | 1 | 230846160 | 230849867 | |
BP347159 | AGT | 1 | 536 | 1 | 230846101 | 230849867 | GGCT | 530 | 582 | 7 | 30544320 | 30544372 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=47) | (# total SNVs=23) |
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(# total SNVs=3) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:230846279-230846279 | p.V106V | 4 |
chr1:230846540-230846540 | p.A19A | 3 |
chr1:230845794-230845794 | p.M268T | 3 |
chr1:230838910-230838910 | p.A479S | 3 |
chr1:230846131-230846131 | p.D156N | 3 |
chr1:230846185-230846185 | p.A138T | 2 |
chr1:230841788-230841788 | p.S339G | 2 |
chr1:230840082-230840082 | p.T376S | 2 |
chr1:230846386-230846386 | p.P71T | 2 |
chr1:230846067-230846067 | p.A177V | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 2 |   | 9 | 1 |   | 4 |   | 1 | 3 |   | 7 | 4 |   |   | 3 | 9 | 5 |   | 15 |
# mutation | 2 | 2 |   | 9 | 1 |   | 5 |   | 1 | 3 |   | 8 | 4 |   |   | 1 | 10 | 5 |   | 12 |
nonsynonymous SNV | 1 | 2 |   | 6 | 1 |   | 2 |   | 1 | 3 |   | 5 | 1 |   |   | 1 | 7 | 3 |   | 8 |
synonymous SNV | 1 |   |   | 3 |   |   | 3 |   |   |   |   | 3 | 3 |   |   |   | 3 | 2 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:230846067 | p.A479S | 3 |
chr1:230846279 | p.V106V | 3 |
chr1:230838910 | p.A177E | 3 |
chr1:230841942 | p.K287N | 2 |
chr1:230841702 | p.V421L | 1 |
chr1:230846235 | p.F300L | 1 |
chr1:230841909 | p.S173P | 1 |
chr1:230846414 | p.D64Y | 1 |
chr1:230839063 | p.R418R | 1 |
chr1:230841707 | p.E299K | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for AGT |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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A1CF,AGT,APCS,APOA2,APOA4,APOC3,ARG1, ASPDH,C8A,C8G,CRP,F2,FGF23,LEAP2, MT1B,PLG,PRAP1,SERPINA10,SERPINA7,SERPINC1,TM4SF5 | ACAT1,ACO2,AGT,ALPK3,ATP5B,ADCK3,CHCHD3, FH,IMMT,MLYCD,OGDH,PDHB,PDHX,PGM1, PHYH,SDHB,SGCG,SLC2A4,SLC6A8,SOX6,TBX15 | ||||
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ABCC2,AGT,CLCN5,EMID1,F7,IL34,LRRC43, MYBPHL,NCKAP5,PHYHIPL,PKLR,PLAGL2,RASL10B,SALL1, SERPINA7,SHROOM4,SLC19A3,SLC23A1,SLC2A8,SLC5A6,TSPAN33 | AGT,ASPDH,CLDN2,CRISP2,DSG3,RMDN3,GALNT14, GGN,GPD1,GRAMD1B,KCNJ16,KCP,MAF,NR1I3, PDZK1P1,PRSS1,SLC5A1,SLC7A7,TMEM92,UNC5CL,ZNF488 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for AGT |
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DB Category | DB Name | DB's ID and Url link |
Organism-specific databases | PharmGKB | PA42; -. |
Organism-specific databases | CTD | 183; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00999 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Hydrochlorothiazide | ![]() | ![]() |
DB00678 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Losartan | ![]() | ![]() |
DB00790 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Perindopril | ![]() | ![]() |
DB01197 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Captopril | ![]() | ![]() |
DB00269 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Chlorotrianisene | ![]() | ![]() |
DB00286 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Conjugated Estrogens | ![]() | ![]() |
DB00890 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Dienestrol | ![]() | ![]() |
DB00255 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Diethylstilbestrol | ![]() | ![]() |
DB00783 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Estradiol | ![]() | ![]() |
DB00655 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Estrone | ![]() | ![]() |
DB00977 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Ethinyl Estradiol | ![]() | ![]() |
DB00394 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Beclomethasone | ![]() | ![]() |
DB00443 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Betamethasone | ![]() | ![]() |
DB01222 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Budesonide | ![]() | ![]() |
DB01410 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Ciclesonide | ![]() | ![]() |
DB01260 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Desonide | ![]() | ![]() |
DB01234 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Dexamethasone | ![]() | ![]() |
DB00180 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Flunisolide | ![]() | ![]() |
DB00588 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Fluticasone Propionate | ![]() | ![]() |
DB00741 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Hydrocortisone | ![]() | ![]() |
DB00959 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Methylprednisolone | ![]() | ![]() |
DB00764 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Mometasone | ![]() | ![]() |
DB01384 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Paramethasone | ![]() | ![]() |
DB00860 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Prednisolone | ![]() | ![]() |
DB00635 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Prednisone | ![]() | ![]() |
DB00896 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Rimexolone | ![]() | ![]() |
DB00620 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Triamcinolone | ![]() | ![]() |
DB00125 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; nutraceutical | L-Arginine | ![]() | ![]() |
DB00155 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; nutraceutical | L-Citrulline | ![]() | ![]() |
DB00435 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Nitric Oxide | ![]() | ![]() |
DB00131 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; nutraceutical | Adenosine monophosphate | ![]() | ![]() |
DB00171 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; nutraceutical | Adenosine triphosphate | ![]() | ![]() |
DB00335 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Atenolol | ![]() | ![]() |
DB00722 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Lisinopril | ![]() | ![]() |
DB01115 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved | Nifedipine | ![]() | ![]() |
DB01258 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | approved; investigational | Aliskiren | ![]() | ![]() |
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Cross referenced IDs for AGT |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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