|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for EIF1AX |
Basic gene info. | Gene symbol | EIF1AX |
Gene name | eukaryotic translation initiation factor 1A, X-linked | |
Synonyms | EIF1A|EIF1AP1|EIF4C|eIF-1A|eIF-4C | |
Cytomap | UCSC genome browser: Xp22.12 | |
Genomic location | chrX :20142635-20159966 | |
Type of gene | protein-coding | |
RefGenes | NM_001412.3, | |
Ensembl id | ENSG00000173674 | |
Description | Putative eukaryotic translation initiation factor 1AeIF-1A X isoformeukaryotic translation initiation factor 1A, X chromosomeeukaryotic translation initiation factor 1A, X-chromosomaleukaryotic translation initiation factor 4C | |
Modification date | 20141207 | |
dbXrefs | MIM : 300186 | |
HGNC : HGNC | ||
Ensembl : ENSG00000173674 | ||
HPRD : 02174 | ||
Vega : OTTHUMG00000022704 | ||
Protein | UniProt: P47813 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_EIF1AX | |
BioGPS: 1964 | ||
Gene Expression Atlas: ENSG00000173674 | ||
The Human Protein Atlas: ENSG00000173674 | ||
Pathway | NCI Pathway Interaction Database: EIF1AX | |
KEGG: EIF1AX | ||
REACTOME: EIF1AX | ||
ConsensusPathDB | ||
Pathway Commons: EIF1AX | ||
Metabolism | MetaCyc: EIF1AX | |
HUMANCyc: EIF1AX | ||
Regulation | Ensembl's Regulation: ENSG00000173674 | |
miRBase: chrX :20,142,635-20,159,966 | ||
TargetScan: NM_001412 | ||
cisRED: ENSG00000173674 | ||
Context | iHOP: EIF1AX | |
cancer metabolism search in PubMed: EIF1AX | ||
UCL Cancer Institute: EIF1AX | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
Top |
Phenotypic Information for EIF1AX(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: EIF1AX |
Familial Cancer Database: EIF1AX |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in THCA 6, |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 6 http://www.sciencedirect.com/science/article/pii/S0092867414012380, 7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | 300186; gene. |
Orphanet | |
Disease | KEGG Disease: EIF1AX |
MedGen: EIF1AX (Human Medical Genetics with Condition) | |
ClinVar: EIF1AX | |
Phenotype | MGI: EIF1AX (International Mouse Phenotyping Consortium) |
PhenomicDB: EIF1AX |
Mutations for EIF1AX |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows EIF1AX related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BQ436116 | GLIS2 | 1 | 241 | 16 | 4388133 | 4388373 | EIF1AX | 242 | 836 | X | 20144300 | 20144883 |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=22) | (# total SNVs=4) |
(# total SNVs=0) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr23:20156719-20156719 | p.R13H | 3 |
chr23:20148634-20148634 | p.D143D | 2 |
chr23:20152120-20152120 | p.W70C | 2 |
chr23:20156731-20156731 | p.G9D | 2 |
chr23:20156742-20156742 | p.? | 2 |
chr23:20150342-20150342 | p.E99* | 2 |
chr23:20156713-20156713 | p.G15D | 2 |
chr23:20159755-20159755 | p.P2S | 2 |
chr23:20156729-20156729 | p.K10E | 2 |
chr23:20148683-20148683 | p.D127A | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   |   | 1 |   |   |   |   | 1 |   | 3 |   |   |   |   | 2 | 1 | 4 | 5 |
# mutation |   | 1 |   |   | 1 |   |   |   |   | 1 |   | 3 |   |   |   |   | 2 | 1 | 4 | 4 |
nonsynonymous SNV |   | 1 |   |   |   |   |   |   |   | 1 |   | 3 |   |   |   |   | 2 | 1 | 4 | 4 |
synonymous SNV |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chrX:20156719 | p.R13H | 3 |
chrX:20148634 | p.G9R | 1 |
chrX:20148683 | p.D143D | 1 |
chrX:20156723 | p.G8R | 1 |
chrX:20148716 | p.D127A | 1 |
chrX:20156729 | p.K7R | 1 |
chrX:20148725 | p.N116S | 1 |
chrX:20156731 | p.P2S | 1 |
chrX:20150322 | p.A113V | 1 |
chrX:20156732 | p.A105A | 1 |
Other DBs for Point Mutations |
Copy Number for EIF1AX in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for EIF1AX |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
API5,CTPS2,CXorf23,DDX3X,EIF1AX,EIF2S3,KLHL15, LIN7C,LRRC58,MBTPS2,MED14,PCNP,POLA1,RLIM, STAG2,SYAP1,TCEANC,THAP5,TRAPPC2,TXLNG,USP9X | BRMS1L,C11orf58,MZT1,C5orf22,CCDC91,COX11,EIF1AX, MOB4,NDFIP2,PCNP,RCHY1,RWDD4,SCOC,SMNDC1, SYPL1,TAF9B,UBE2D3,VAPA,VTA1,YAF2,ZNF639 |
APOO,ARSE,CTPS2,EIF1AX,EIF2S3,FAM104B,FUNDC1, GEMIN8,HDHD1,MED14,JPX,PNPLA4,PRDX4,PRPS2, RAB9A,RBBP7,RPS4X,SYAP1,TRAPPC2,UXT,VBP1 | BTF3,TMEM230,CWC15,DPH5,EEF1A1P9,EIF1AX,EIF3E, FAM200A,FUNDC1,GGPS1,METTL9,CMC4,OLA1,ORC5, RPL14,RPL7,RPL7A,RPS4X,RSL1D1,TATDN1,ZFAND1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for EIF1AX |
There's no related Drug. |
Top |
Cross referenced IDs for EIF1AX |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |