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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for EIF2S3 |
Basic gene info. | Gene symbol | EIF2S3 |
Gene name | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | |
Synonyms | EIF2|EIF2G|EIF2gamma|eIF-2gA | |
Cytomap | UCSC genome browser: Xp22.2-p22.1 | |
Genomic location | chrX :24073064-24096927 | |
Type of gene | protein-coding | |
RefGenes | NM_001415.3, | |
Ensembl id | ENSG00000130741 | |
Description | eIF-2-gamma XeIF-2gXeukaryotic translation initiation factor 2 subunit 3eukaryotic translation initiation factor 2 subunit gamma Xeukaryotic translation initiation factor 2G | |
Modification date | 20141207 | |
dbXrefs | MIM : 300161 | |
HGNC : HGNC | ||
HPRD : 02155 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_EIF2S3 | |
BioGPS: 1968 | ||
Gene Expression Atlas: ENSG00000130741 | ||
The Human Protein Atlas: ENSG00000130741 | ||
Pathway | NCI Pathway Interaction Database: EIF2S3 | |
KEGG: EIF2S3 | ||
REACTOME: EIF2S3 | ||
ConsensusPathDB | ||
Pathway Commons: EIF2S3 | ||
Metabolism | MetaCyc: EIF2S3 | |
HUMANCyc: EIF2S3 | ||
Regulation | Ensembl's Regulation: ENSG00000130741 | |
miRBase: chrX :24,073,064-24,096,927 | ||
TargetScan: NM_001415 | ||
cisRED: ENSG00000130741 | ||
Context | iHOP: EIF2S3 | |
cancer metabolism search in PubMed: EIF2S3 | ||
UCL Cancer Institute: EIF2S3 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for EIF2S3(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: EIF2S3 |
Familial Cancer Database: EIF2S3 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: EIF2S3 |
MedGen: EIF2S3 (Human Medical Genetics with Condition) | |
ClinVar: EIF2S3 | |
Phenotype | MGI: EIF2S3 (International Mouse Phenotyping Consortium) |
PhenomicDB: EIF2S3 |
Mutations for EIF2S3 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows EIF2S3 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AI830759 | EIF2S3 | 1 | 163 | X | 24095064 | 24095226 | HNRNPA3 | 157 | 419 | 2 | 178087487 | 178087749 | |
CB131978 | ZNF480 | 20 | 225 | 19 | 52819154 | 52824975 | EIF2S3 | 223 | 378 | X | 24096214 | 24096369 | |
BE177610 | SLC19A2 | 2 | 352 | 1 | 169434289 | 169434644 | EIF2S3 | 347 | 525 | X | 24086202 | 24089828 | |
AW580222 | GFPT1 | 33 | 494 | 2 | 69559776 | 69560231 | EIF2S3 | 491 | 623 | X | 24080551 | 24080683 | |
BG774247 | EIF2S3 | 102 | 142 | X | 24095884 | 24095924 | H19 | 143 | 298 | 11 | 2018904 | 2019057 | |
BM969453 | WDR70 | 369 | 408 | 5 | 37389269 | 37389308 | EIF2S3 | 405 | 611 | X | 24095045 | 24095251 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=24) | (# total SNVs=15) |
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(# total SNVs=0) | (# total SNVs=1) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr23:24086170-24086170 | p.V319V | 2 |
chr23:24075780-24075780 | p.R98W | 2 |
chr23:24086216-24086216 | p.G335S | 2 |
chr23:24075797-24075797 | p.R103R | 2 |
chr23:24089747-24089747 | p.G362A | 2 |
chr23:24084129-24084129 | p.D263H | 2 |
chr23:24078274-24078274 | p.V151V | 1 |
chr23:24086119-24086119 | p.S302S | 1 |
chr23:24075581-24075581 | p.K59N | 1 |
chr23:24089825-24089825 | p.G388E | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 2 | 2 | 3 | 2 |   |   | 1 | 1 | 1 |   | 3 | 1 |   |   |   | 1 | 1 |   | 9 |
# mutation | 2 | 2 | 2 | 3 | 2 |   |   | 1 | 1 | 1 |   | 3 | 1 |   |   |   | 1 | 1 |   | 9 |
nonsynonymous SNV | 2 | 2 | 2 | 2 | 1 |   |   | 1 |   | 1 |   | 3 |   |   |   |   |   | 1 |   | 7 |
synonymous SNV |   |   |   | 1 | 1 |   |   |   | 1 |   |   |   | 1 |   |   |   | 1 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chrX:24084129 | p.K59N | 1 |
chrX:24094881 | p.G335S | 1 |
chrX:24075780 | p.H65Y | 1 |
chrX:24086119 | p.G335G | 1 |
chrX:24094891 | p.D93G | 1 |
chrX:24075832 | p.E370K | 1 |
chrX:24086128 | p.R98W | 1 |
chrX:24078221 | p.R385C | 1 |
chrX:24086216 | p.T115M | 1 |
chrX:24078247 | p.K397E | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for EIF2S3 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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APOO,CTPS2,EIF1AX,EIF2A,EIF2S3,KLHL15,MED14, MRPL3,MRPL37,NPM1,OFD1,OLA1,PIGA,POLA1, RAB9A,RSL1D1,SMS,SYAP1,TRAPPC2,TXLNG,USP9X | CCT4,CEP57,EIF2A,EIF2S3,EIF3E,EIF3L,EIF3M, LTA4H,NAP1L1,LRRC75A-AS1,PABPC1,PCBP2,PMPCB,RPL15, RPL22,RSL24D1,SUPT3H,TATDN1,TIMM9,TOMM20,ZNF277 | ||||
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APOO,CTPS2,EIF1AX,EIF2S3,FUNDC1,GEMIN8,HCCS, HSD17B10,MCTS1,MED14,NONO,OFD1,PDHA1,JADE3, RBBP7,RPS4X,SCML1,SMS,SYAP1,TRAPPC2,TXLNG | SMG8,CREBL2,EIF2S3,EIF3H,EIF4B,IMPDH2,KBTBD7, LTA4H,MANBA,PAIP2B,PNLIPRP3,RPL22,RPS4X,RRAGD, TXNDC16,WDR48,ZNF607,ZNF619,ZNF780A,ZXDA,ZXDB |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for EIF2S3 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00877 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | approved; investigational | Sirolimus | ![]() | ![]() |
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Cross referenced IDs for EIF2S3 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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