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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ADCY4 |
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Phenotypic Information for ADCY4(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ADCY4 |
Familial Cancer Database: ADCY4 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PURINE_METABOLISM REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
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OMIM | 600292; gene. |
Orphanet | |
Disease | KEGG Disease: ADCY4 |
MedGen: ADCY4 (Human Medical Genetics with Condition) | |
ClinVar: ADCY4 | |
Phenotype | MGI: ADCY4 (International Mouse Phenotyping Consortium) |
PhenomicDB: ADCY4 |
Mutations for ADCY4 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ADCY4 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=70) | (# total SNVs=29) |
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(# total SNVs=3) | (# total SNVs=1) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:24798609-24798609 | p.R450W | 3 |
chr14:24787905-24787905 | p.N1012N | 2 |
chr14:24787668-24787668 | p.N1063S | 2 |
chr14:24795358-24795358 | p.R528fs*3 | 2 |
chr14:24787683-24787683 | p.C1058F | 2 |
chr14:24788604-24788604 | p.I924I | 2 |
chr14:24793333-24793333 | p.G661R | 2 |
chr14:24795366-24795366 | p.R525H | 2 |
chr14:24799066-24799066 | p.G406V | 2 |
chr14:24792155-24792155 | p.S766* | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 5 | 2 | 1 | 13 | 3 |   | 3 | 2 | 2 | 1 |   | 10 | 4 | 3 |   | 1 | 12 | 9 | 1 | 10 |
# mutation | 6 | 2 | 1 | 15 | 3 |   | 3 | 2 | 2 | 1 |   | 11 | 4 | 3 |   | 1 | 12 | 8 | 1 | 12 |
nonsynonymous SNV | 3 | 2 |   | 11 | 1 |   | 3 | 1 | 1 |   |   | 8 | 4 | 2 |   | 1 | 3 | 6 |   | 11 |
synonymous SNV | 3 |   | 1 | 4 | 2 |   |   | 1 | 1 | 1 |   | 3 |   | 1 |   |   | 9 | 2 | 1 | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:24795366 | p.R525H,ADCY4 | 3 |
chr14:24789026 | p.S941F,ADCY4 | 2 |
chr14:24787668 | p.N1063S,ADCY4 | 2 |
chr14:24798413 | p.F885F,ADCY4 | 2 |
chr14:24788554 | p.A460T,ADCY4 | 2 |
chr14:24798345 | p.L790L,ADCY4 | 1 |
chr14:24802138 | p.A613S,ADCY4 | 1 |
chr14:24787658 | p.D433D,ADCY4 | 1 |
chr14:24792232 | p.E219E,ADCY4 | 1 |
chr14:24799092 | p.R982C,ADCY4 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ADCY4 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ADCY4,ARHGEF15,AVPR2,CCM2L,CLEC14A,CXorf36,ECSCR, GPIHBP1,GPR146,KANK3,LRRC70,MMRN2,NOTCH4,PDE2A, PEAR1,ROBO4,S1PR1,SCARF1,TIE1,TPO,USHBP1 | ADCY4,ARHGAP17,ARHGEF15,CCM2L,CXorf36,ESAM,FAM65A, FGD5,GNAZ,LRRC32,MMRN2,MYO7B,NOTCH4,NOVA2, PDE2A,ROBO4,SCARF1,SH2D3C,SHANK3,USHBP1,VWF | ||||
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ADCY4,ARHGEF15,BCL6B,CCM2L,CD34,CLEC1A,CXorf36, ECSCR,ERG,FLI1,HSPA12B,KANK3,MMRN2,NOTCH4, PECAM1,S1PR1,SH2D3C,STARD8,TIE1,USHBP1,ZNF154 | ADCY4,CLEC4GP1,CP,EFEMP1,FAM20A,GJA4,IRX5, ITIH4,JAG2,LOC90246,MBL1P,MEG3,MMP14,NOTCH4, PCOLCE,PLXND1,RAPGEF3,SCARF1,SFRP1,SHANK3,TIE1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ADCY4 |
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DB Category | DB Name | DB's ID and Url link |
Chemistry | ChEMBL | CHEMBL2097167; -. |
Organism-specific databases | PharmGKB | PA24562; -. |
Organism-specific databases | CTD | 196883; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00938 | adenylate cyclase 4 | approved | Salmeterol | ![]() | ![]() |
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Cross referenced IDs for ADCY4 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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